Differential Expression of the β2-Adrenergic Receptor by Th1 and Th2 Clones Implications for Cytokine Production and B Cell Help

Journal of Immunology

Volumn 158, Issue 9, 1997, Pages 4200-4210

  Sanders, Virginia M ^a   Baker, Raymond A ^a   Ramer Quinn, D Susanne ^a   Kasprowicz, Deborah J ^a   Fuchs, Bruce A ^b   Street, Nancy E ^c  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 4; PINDOLOL; TERBUTALINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CLONE; DRUG EFFECT; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ADRENERGIC BETA-AGONISTS; ANIMALS; CLONE CELLS; CYCLIC AMP; CYTOKINES; FEMALE; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PINDOLOL; RECEPTORS, ADRENERGIC, BETA-2; T-LYMPHOCYTE SUBSETS; TERBUTALINE; TH1 CELLS; TH2 CELLS;

EID: 0031135311     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. + T cells. Immunol. Rev. 123:209.
2. + T cells. Annu. Rev. Immunol. 12:635.
3. Aebischer, I., and B. M. Stadler. 1996. Th1-Th2 cells in allergic responses: at the limits of a concept. Adv. Immunol. 61:341.
4. Stevens, T. L., A. Bossie, V. M. Sanders, R. Fernandez-Botran, R. L. Coffman, T. R. Mosmann, and E. S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255.
5. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, J. P. Beckmann, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
6. Gajewski, T. F., S. R. Schell, and F. W. Fitch. 1990. Evidence implicating utilization of different T cell receptor-associated signaling pathways by Th-1 and Th-2 clones. J. Immunol. 144:4110.
7. Novak, T. J., and E. V. Rothenberg. 1990. cAMP inhibits induction of interleukin 2 but not of inlerleukin 4 in T cells. Proc. Natl. Acad. Sci. USA 87:9353.
8. Munoz, E., A. M. Zubiaga, M. Merrow, N. P. Sauter, and B. T. Huber. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:95.
9. Rall, T. W. 1972. Role of adenosine 3′,5′-monophosphate (cyclic AMP) in actions of catecholamines. Pharmacol. Rev. 24:399.
10. Kobilka, B. 1992. Adrenergic receptors as models for G protein-coupled receptors. Annu. Rev. Neurosci. 15:87.
11. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:108.
12. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150:5321.
13. Feiten, D. L., K. D. Ackerman, S. J. Wiegand, and S. Y. Felten. 1987. Noradrenergic sympathetic innervation of the spleen. I. Nerve fibers associate with lymphocytes and macrophages in specific compartments of the splenic while pulp. J. Neurosci. Res. 18:28.
14. Bulloch, K., and W. Pomerantz. 1984. Autonomic nervous system innervation of thymic related lymphoid tissue in wild-type and nude mice. J. Comp. Neurol. 228:57.
15. Felten, S. Y., and J. Olschowka. 1987. Noradrenergic sympathetic innervation of the spleen. II. Tyrosine hydroxylase (TH)-positive nerve terminals form synaptic-like contacts on lymphocytes in the splenic while pulp. J. Neurosci. Res. 18:37.
16. Fuchs, B. A., K. S. Campbell, and A. E. Munson. 1988. Norepinephrine and serotonin content of the murine spleen: its relationship to lymphocyte beta-adrenergic receptor density and the humoral immune response in vivo and in vitro. Cell. Immunol. 117:339.
17. 2-adrenergic, spleen-dependent process. Am. J. Physiol. 258:E191.
18. Khan, M. M., P. Sansoni, E. D. Silverman, E. G. Engleman, and K. L. Melmon. 1986. β-Adrenergic receptors on human suppressor, helper, and cytolytic lymphocytes. Biol. Psychiatry 35:1137.
19. Fuchs, B. A., J. W. Albright, and J. F. Albright. 1988. β-Adrenergic receptor on murine lymphocytes: density varies with cell maturity and lymphocyte subtype and is decreased after antigen administration. Cell. Immunol. 114:231.
20. Rudojcic, T., S. Baird, D. Darko, D. Smith, and K. Bulloch. 1991. Changes in beta-adrenergic receptor distribution on immunocytes during differentiation: an analysis of T cells and macrophages. J. Neurosci. Res. 30:328.
21. Makman, M. H. 1971. Properties of adenylate cyclase of lymphoid cells. Proc. Natl. Acad. Sci. USA 68:885.
22. 3H-alprenolol binding. J. Clin. Invest. 57:149.
23. Conolly, M. E., and J. K. Greenacre. 1977. The beta-adrenoceptor of the human lymphocyte and human lung parenchyma. Br. J. Pharmacol. 59:17.
24. Bishopric, N. H., H. J. Cohen, and R. J. Lefkowitz. 1980. β-Adrenergic receptors in lymphocyte subpopulations. J. Allergy Clin. Immunol. 65:29.
25. Bourne, H. R., and K. L. Melmon. 1971. Adenyl cyclase in human leukocytes: evidence lor activation by separate β-adrenergic and prostaglandin receptors. J. Pharmacol. Exp. Ther. 178:1.
26. Pochet, R., and G. Delespesse. 1983. β-Adrenoceptors display different efficiency on lymphocyte subpopulations. Biochem. Pharmacol. 32:1651.
27. Wacholtz, M. C., R. Minakuchi, and P. E. Lipsky. 1991. Characterization of the 3′,5′-cyclic adenosine monophosphate-mediated regulation of IL2 production by T cells and Jurkat cells. Cell. Immunol. 135:285.
28. Mary, D., J.-F. Peyron, P. Auberger, C. Aussel, and M. Fehlmann. 1989. Modulation of T cell activation by differential regulation of the phosphorylation of two cytosolic proteins. J. Biol. Chem. 264:14498.
29. Kurt-Jones, E. A., S. Hamberg, J. Ohara, W. E. Paul, and A. K. Abbas. 1987. Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J. Exp. Med. 166:1774.
30. Boom, W. H., D. Liana, and A. K. Abbas. 1988. Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4-and interleukin 2-producing T cell clones on resting B lymphocytes. J. Exp. Med. 167:1350.
31. Cher, D. J., and T. R. Mosmann. 1987. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones. J. Immunol. 138: 3688.
32. DeKruyff, R. H., S.-T. Ju, A. J. Hunt, T. R. Mosmann, and D. T. Umetsu. 1989. Induction of antigen-specific antibody responses in primed and unprimed B cells: functional heterogeneity among Th1 and Th2 clones. J. Immunol. 142:2575.
33. + T cells: IL-5 is essential for induction of antigen-specific antibody responses by Th2 but not Th1 clones. Eur. J. Immunol. 20:2219.
34. Stack, R. M., D. J. Lenschow, G. S. Gray, J. A. Bluestone, and F. W. Filch. 1994. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J. Immunol. 152:5723.
35. Matis, L. A., D. L. Longo, S. M. Hedrick, C. Hannum, E. Margoliash, and R. H. Schwartz. 1983. Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C. J. Immunol. 130:1527.
36. Tony, H.-P., N. E. Phillips, and D. C. Parker. 1985. Role of membrane immunoglobulin (Ig) crosslinking in membrane Ig-mediated, major histocompatibility-restricted T cell-B cell cooperation. J. Exp. Med. 162:1695.
37. - T suppressor cells inhibit the major histocompatibility complex-restricted interaction of T helper cells with B cells and/or accessory cells. J. Exp. Med. 158:1178.
38. Kaye, J., S. Porcelli, J. Tite, B. Jones, and C. A. Janeway, Jr. 1983. Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J. Exp. Med. 158:836.
39. 2-Adrenoceptor stimulation increases the number of antigen-specific precursor B lymphocytes that differentiate into IgM-secreting cells without affecting burst size. J. Immunol. 148:1822.
40. Snow, E. C., E. S. Vitetta, and J. W. Uhr. 1983. Activation of antigen-enriched B cells. I. Purification and response to thymus-independent antigens. J. Immunol. 130:607.
41. Myers, C. D., V. M. Sanders, and E. S. Vitetta. 1986. Isolation of antigen-binding virgin and memory B cells. J. Immunol. Methods 92:45.
42. Vitetta, E. S., A. Bossie, R. Fernandez-Botran, C. D. Myers, K. G. Oliver, V. M. Sanders, and T. L. Stevens. 1987. Interaction and activation of antigen-specific T and B cells. Immunol. Rev. 99:193.
43. Collins, S., M. G. Caron, and R. J. Lefkowitz. 1991. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu. Rev. Physiol. 53:497.
44. Shimizu, N., T. Hori, and H. Nakane. 1994. An interleukin-1-β-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: an in vivo microdialysis study in conscious rats. Brain Behav. Immun. 7:14.
45. Sanders, V. M., and A. E. Munson. 1984. Kinetics of the enhancing effect produced by norepinephrine and terbutlaine on the murine primary antibody response in vitro. J. Pharmacol. Exp. Ther. 231:527.
46. Sanders, V. M., J. M. Snyder, J. W. Uhr, and E. S. Vitetta. 1986. Characterization of the physical interaction between antigen-specific B and T cells. J. Immunol. 137:2395.
47. Munson, P. J. 1987. A User's Guide to LIGAND: Data Analysis and Curve-Fitting for Ligand Binding Experiments. Systex, Inc., Beltsville, MD.
48. Openshaw, P., E. E. Murphy, N. A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper \and T helper 2 populations. J. Exp. Med. 182: 1357.
49. Assenmacher, M., J. Schmitz, and A. Radbruch. 1994. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells. Eur. J. Immunol. 24:1097.
50. Loveland, B. E., B. Jarrott, and I. F. C. McKenzie. 1981. The detection of β-adrenoceptors on murine lymphocytes. Int. J. Immunopharmacol. 3:45.
51. 3H]dihydroalprenolol binding to intact and broken cell preparations of human peripheral blood lymphocytes. Eur. J. Pharmacol. 85:185.
52. Sanders, V. M., and A. E. Munson. 1984. β-Adrenoceptor mediation of the enhancing effect of norepinephrine on the murine primary antibody response in vitro. J. Pharmacol. Exp. Ther. 230:183.
53. Khan, M. M., E. Silverman, E. G. Engleman, and K. L. Melmon. 1985. Responses of subpopulations of human helper T cells to autocoids. Proc. West. Pharmacol. Soc. 28:225.
54. Khan, M. M., K. L. Melmom, C. G. Fathman, B. Hertel-Wulff, and S. Strober. 1985. The effects of autocoids on cloned murine lymphoid cells: modulation of IL-2 secretion and the activity of natural suppressor cells. J. Immunol. 134:4100.
55. Kruszewska, B., S. Y. Felten, and J. A. Moynihan. 1995. Alterations in cytokine and antibody production following chemical sympathectomy in two strains of mice. J. Immunol. 155:4613.
56. Diamantstein, T., and A. Ulmer. 1975. The antagonistic action of cyclic GMP and cyclic AMP on proliferation of B and T lymphocytes. Immunology 28:113.
57. Vischer, T. L. 1976. The differential effect of cAMP on lymphocyte stimulation by T-or B-cell mitogens. Immunology 30:735.
58. Watson, J. 1975. The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis. J. Exp. Med. 141:97.
59. Johnson, D. L., R. C. Ashmore, and M. A. Gordon. 1981. Effects of β-adrenergic agents on the murine lymphocyte response to mitogen stimulation. J. Immunopharmacol. 3:205.
60. Muthusamy, N., A. R. Baluyut, and B. Subbarao. 1991. Differential regulation of surface Ig-and Lyb2-mediated B cell activation by cyclic AMP. I. Evidence for alternative regulation of signalling through two different receptors linked to phosphatidylinositol hydrolysis in murine B cells. J. Immunol. 147:2483.
61. Cohen, D. P., and T. L. Rothstein. 1989. Adenosine 3′,5′-cyclic monophosphate modulates the mitogenic responses of murine B lymphocytes. Cell. Immunol. 121:113.
62. Whisler, R. L., L. Beiqing, I. S. Grants, and Y. G. Newhouse. 1992. Cyclic AMP modulation of human B cell proliferative responses: role of cAMP-dependent protein kinases in enhancing B cell responses to phorbol diesters and ionomycin. Cell. Immunol. 142:398.
63. Blomhoff, H. K., E. B. Smeland, K. Beiske, R. Blomhoff, E. Ruud, T. Bjoro, S. Pfeifer-Ohlsson, R. Watt, S. Funderud, T. Godal, and R. Ohlsson. 1987. Cyclic AMP-mediated suppression of normal and neoplastic B cell proliferation is associated with regulation of myc and Ha-ras protooncogenes. J. Cell. Physiol. 131:426.
64. 1 to S transition of the B cell cycle. J. Immunol. 133:1283.
65. Holte, H., P. Torjesen, H. K. Blomhoff, E. Ruud, S. Funderud, and E. B. Smeland. 1988. Cyclic AMP has the ability to influence multiple events during B cell stimulation. Eur. J. Immunol. 18:1359.
66. Shreurs, A. J. M., D. H. G. Versteeg, and F. P. Nijkamp. 1982. Involvement of catecholamines in Haemophilus influenzae induced decrease of β-adrenoceptor function. Naunyn Schmiedebergs Arch. Pharmarol. 320:235.
67. Burchiel, S. W., and K. L. Melmon. 1979. Augmentation of the in vitro humoral immune response by pharmacologie agents. II. The comparison of the effects of antiproliferative agents with dibutyryl cAMP. Immunopharmacology 1:151.
68. Kouassi, E., Y. S. Li, W. Boukhris, I. Millet, and J.-P. Revillard. 1988. Opposite effects of the catecholamines dopamine and norepinephrine on murine polyclonal B-cell activation. Immunopharmacology 16:125.
69. Watson, J., R. Epstein, and M. Conn. 1973. Cyclic nucleotides as intracellular mediators of the expression of antigen-sensitive cells. Nature 246:405.
70. 2 promotes IL-4-induced IgE and IgG1 synthesis. J. Immunol. 145:2644.
71. 2, immune complexes, and IFN-γ. J. Immunol. 147: 2500.
72. Burchiel, S. W., and K. L. Melmon. 1979. Augmentation of the in vitro humoral immune response by pharmacologie agents. 1. An explanation of the differential enhancement of humoral immunity via agents that elevate cAMP. Immunopharmacology 1:137.
73. Teh, H. S., and V. Paetkau. 1976. Regulation of immune responses. II. The cellular basis of cyclic AMP effects on humoral immunity. Cell. Immunol. 24: 220.
74. + T cells while decreasing IL-2 release and NF-AT induction. Int. Immunol. 6:1333.
75. 2 or the beta-adrenergic receptors: relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation. Cell. Immunol. 158:182.