Chronic treatment with ginsenoside Rg3 induces Akt-dependent senescence in human glioma cells

International Journal of Oncology

Volumn 41, Issue 5, 2012, Pages 1669-1674

  Sin, Seong ^a,b   Kim, Sung Young ^b   Kim, Sung Su ^a,b  

^a Kyung Hee University   (South Korea)

^b Soram Cancer and Immunotherapy Research Center   (South Korea)

Author keywords

Akt; Ginsenoside Rg3; Glioma; ROS; Senescence

Indexed keywords

BETA GALACTOSIDASE; GINSENOSIDE RG 3; LIPOCORTIN 5; PROTEIN KINASE B; PROTEIN P16; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL AGING; CELL CYCLE ARREST; CONTROLLED STUDY; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL AGING; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME ACTIVATION; GINSENOSIDES; GLIOMA; HUMANS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84867802121     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1604     Document Type: Article

References (37)

1. Vergel M, Marin JJ, Estevez P and Carnero A: Cellular senescence as a target in cancer control. J Aging Res 2011: 725365, 2010.
2. Schmitt CA: Senescence, apoptosis and therapy - cutting the lifelines of cancer. Nat Rev Cancer 3: 286-295, 2003.
3. Shay JW and Roninson IB: Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23: 2919-2933, 2004. (Pubitemid 38638853)
4. Hornsby PJ: Senescence as an anticancer mechanism. J Clin Oncol 25: 1852-1857, 2007.
5. Ventura A, Kirsch DG, McLaughlin ME, et al: Restoration of p53 function leads to tumour regression in vivo. Nature 445: 661-665, 2007. (Pubitemid 46232887)
6. Ohgaki H and Kleihues P: Genetic pathways to primary and secondary glioblastoma. Am J Pathol 170: 1445-1453, 2007. (Pubitemid 47339290)
7. Kitagawa I, Yoshikawa M, Yoshihara M, Hayashi T and Taniyama T: Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra. Yakugaku Zasshi 103: 612-622, 1983 (In Japanese). (Pubitemid 13027064)
8. Helms S: Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev 9: 259-274, 2004.
9. Yuan HD, Quan HY, Zhang Y, Kim SH and Chung SH: 20(S)-Ginsenoside Rg3-induced apoptosis in HT-29 colon cancer cells is associated with AMPK signaling pathway. Mol Med Rep 3: 825-831, 2010.
10. Wang BS, Zhang LS, Song DM, Zhang JH and Liu YM: Effect of gensenoside Rg3 on apoptosis of Hep-2 and expression of HIF-1alha in human laryngeal cancer cell line under anoxic conditions. Zhong Yao Cai 32: 102-106, 2009 (In Chinese).
11. Kim HS, Lee EH, Ko SR, Choi KJ, Park JH and Im DS: Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 27: 429-435, 2004.
12. Jian J, Hu ZF and Huang Y: Effect of ginsenoside Rg3 on Pim-3 and Bad proteins in human pancreatic cancer cell line PANC-1. Ai Zheng 28: 461-465, 2009 (In Chinese).
13. Dimri GP, Lee X, Basile G, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367, 1995.
14. Solomon DA, Kim JS, Jenkins S, et al: Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. Cancer Res 68: 2564-2569, 2008. (Pubitemid 351556252)
15. Nogueira V, Park Y, Chen CC, et al: Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14: 458-470, 2008.
16. Dolado I and Nebreda AR: AKT and oxidative stress team up to kill cancer cells. Cancer Cell 14: 427-429, 2008.
17. Campisi J and d'Adda di Fagagna F: Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740, 2007. (Pubitemid 47312822)
18. Schmitt CA: Cellular senescence and cancer treatment. Biochim Biophys Acta 1775: 5-20, 2007.
19. Roninson IB: Tumor cell senescence in cancer treatment. Cancer Res 63: 2705-2715, 2003.
20. te Poele RH, Okorokov AL, Jardine L, Cummings J and Joel SP: DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 62: 1876-1883, 2002. (Pubitemid 34408516)
21. Nardella C, Clohessy JG, Alimonti A and Pandolfi PP: Pro-senescence therapy for cancer treatment. Nat Rev Cancer 11: 503-511, 2011.
22. Lleonart ME, Artero-Castro A and Kondoh H: Senescence induction; a possible cancer therapy. Mol Cancer 8: 3, 2009.
23. Chang BD, Xuan Y, Broude EV, et al: Role of p53 and p21waf1/ cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 18: 4808-4818, 1999. (Pubitemid 29423564)
24. Datta SR, Brunet A and Greenberg ME: Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927, 1999.
25. Blume-Jensen P and Hunter T: Oncogenic kinase signalling. Nature 411: 355-365, 2001. (Pubitemid 32467045)
26. Testa JR and Bellacosa A: AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98: 10983-10985, 2001. (Pubitemid 32928669)
27. Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H and Komuro I: Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 23: 212-220, 2004. (Pubitemid 38165761)
28. Lee JJ, Kim BC, Park MJ, et al: PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell Death Differ 18: 666-677, 2011.
29. Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602, 1997. (Pubitemid 27152402)
30. Wright WE and Shay JW: Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr Opin Genet Dev 11: 98-103, 2001. (Pubitemid 32119285)
31. Passos JF and Von Zglinicki T: Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res 40: 1277-1283, 2006. (Pubitemid 44698277)
32. Beckman KB and Ames BN: The free radical theory of aging matures. Physiol Rev 78: 547-581, 1998. (Pubitemid 28182903)
33. Ben-Porath I and Weinberg RA: The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37: 961-976, 2005. (Pubitemid 40311739)
34. Hagen TM, Yowe DL, Bartholomew JC, et al: Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci USA 94: 3064-3069, 1997. (Pubitemid 27157264)
35. Lee AC, Fenster BE, Ito H, et al: Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem 274: 7936-7940, 1999.
36. Chen Q and Ames BN: Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 91: 4130-4134, 1994. (Pubitemid 24143386)
37. Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagan JD and Ames BN: Molecular analysis of H2O2-induced senescentlike growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 332: 43-50, 1998. (Pubitemid 28239316)