Novel insights of structure-based modeling for RNA-targeted drug discovery

Journal of Chemical Information and Modeling

Volumn 52, Issue 10, 2012, Pages 2741-2753

  Chen, Lu ^a   Calin, George A ^a,b   Zhang, Shuxing ^a  

^a Department of Experimental Therapeutics   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DIAGNOSIS; GOLD; LIGANDS;

BINDING AFFINITIES; COMPREHENSIVE EVALUATION; INTEGRATED APPROACH; MODELING TECHNIQUE; RATIONAL DRUG DESIGNS; SCORING FUNCTIONS; VIRTUAL SCREENING; WEAK CORRELATION;

RNA;

LIGAND; RNA;

ALGORITHM; ARTICLE; BINDING SITE; CHEMISTRY; COMPUTER INTERFACE; CONFORMATION; DRUG ANTAGONISM; DRUG DESIGN; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; HUMAN; METHODOLOGY; MOLECULAR DOCKING; MOLECULAR LIBRARY; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; RESEARCH DESIGN; RNA; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; USER-COMPUTER INTERFACE;

EID: 84867798654     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci300320t     Document Type: Article

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