Gamma interferon dominates the murine cytokine response to the agent of human granulocytic ehrlichiosis and helps to control the degree of early rickettsemia

Infection and Immunity

Volumn 68, Issue 4, 2000, Pages 1827-1833

  Akkoyunlu, Mustafa ^a   Fikrig, Erol ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTEREMIA; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EHRLICHIOSIS; FEMALE; IMMUNOCOMPETENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BACTEREMIA; CONCANAVALIN A; CYTOKINES; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; EHRLICHIOSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HL-60 CELLS; HUMANS; IMMUNOGLOBULIN G; INTERFERON TYPE II; MICE; MICE, INBRED C3H; NEUTROPHILS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RICKETTSIA; SPLEEN; T-LYMPHOCYTES; TIME FACTORS;

EID: 0034100619     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.4.1827-1833.2000     Document Type: Article

References (43)

1. Abbas, A., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787-793.
2. Adachi, J. A., E. M. Grimm, P. Johnson, M. Uthman, B. Kaplan, and R. M. Rakita. 1997. Human granulocytic ehrlichiosis in a renal transplant patient: case report and review of the literature. Transplantation 64:1139-1142.
3. Aguero-Rosenfeld, M. E., H. W. Horowitz, G. P. Wormser, D. F. McKenna, J. Nowakowski, J. Munoz, and J. S. Dumler. 1996. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Ann. Intern. Med. 125:904-908.
4. Anthony, S. J., J. S. Dumler, and E. Hunter. 1995. Human ehrlichiosis in a liver transplant recipient. Transplantation 60:879.
5. Bakken, J. S., J. Krueth, C. Wilson-Nordskog, R. L. Tilden, K. Asanovich, J. S. Dumler. 1996. Clinical and laboratory characteristics of human granulocylic ehrlichiosis. JAMA 275:199-205.
6. Bakken, J. S., S. A. Erlenmeyer, R. J. Kanoff, T. C. Silvesterini II, D. D. Goodwin, and J. S. Dumler. 1998. Demyelinating polyneuropathy associated with human granulocytic ehrlichiosis. Clin. Infect. Dis. 27:1323-1324.
7. Bakken, J. S., J. S. Dumler, S. M. Chen, M. R. Eckman, L. L. Van Etta, and D. H. Walker. 1994. Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? JAMA 272:212-218.
8. Bakken, J. S., J. Krueth, R. L. Tilden, J. S. Dumler, B. E. Kristiansen. 1996. Serological evidence of human granulocytic ehrlichiosis in Norway. Eur. J. Clin. Microbiol. Infect. Dis. 15:829-832.
9. Bakken, J. S., P. Goellner, M. van Etten, D. Z. Boyle, O. L. Swonger, S. Mattson, J. K. Krueth, R. L. Tilden, K. Asanovich, J. Walls, and J. S. Dumler. 1998. Seroprevalance of human granulocytic ehrlichiosis among permanent residents of northwestern Wisconsin. Clin. Infect. Dis. 27:1491-1496.
10. Beckerman, K. P., H. W. Rogers, J. A. Corbett, R. D. Schreiber, M. L. McDaniel, and E. R. Unanue. 1993. Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J. Immunol. 150:888-895.
11. Bogdan, C., Y. Vodovotz, J. Paik, Q. Xie, and C. Nathan. 1994. Mechanisms of suppression of NOS expression by IL-4 in primary mouse macrophages. J. Leukoc. Biol. 55:227-233.
12. Brunet, L. R., D. W. Dunne, and E. J. Pearce. 1998. Cytokine interaction and immune responses during Schistosoma mansoni infection. Parasitol. Today 14:422-427.
13. Dalton, D. K., S. Pitts-Meek, S. Keshav, S. I. Figari, A. Bradley, and T. A. Steward. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1739-1742.
14. Dumler, J. S., and J. S. Bakken. 1998. Human ehrlichiosis: newly recognized infections transmitted by ticks. Annu. Rev. Med. 49:201-213.
15. Dumler, J. S., and J. S. Bakken. 1996. Human granulocytic ehrlichiosis in Wisconsin and Minnesota: a frequent infection with the potential for persistence. J. Infect. Dis. 173:1027-1030.
16. Fingerle, V., J. L. Goodman, R. C. Johnson, T. J. Kurtti, D. G. Munderloh, and B. Wilske. 1997. Human granulocytic ehrlichiosis in southern Germany: increased seroprevalence in high-risk groups. J. Clin. Microbiol. 35:3244-3247.
17. Gazinelli, R. T., I. P. Oswald, S. L. James, and A. Sher. 1992. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J. Immunol. 148:1792.
18. + T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J. Immunol. 157:798-805.
19. Hardalo, C. J., V. Quagliarello, and J. S. Dumler. 1996. Human granulocytic ehrlichiosis in Connecticut: report of a fatal case. Clin. Infect. Dis. 21:910-914.
20. Hodzic, E., J. W. Ijdo, S. Feng, P. Katavalos, W. Sun, C. H. Maretzki, D. Fish, E. Fikrig, S. R. Telford III, and S. W. Barthold. 1998. Granulocytic ehilichiosis in the laboratory mouse. J. Infect. Dis. 177:737-745.
21. Hodzic, E., D. Fish, C. M. Maretzki, A. M. De Silva, S. Feng, and S. W. Barthold. 1998. Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. J. Clin. Microbiol. 36:3574-3578.
22. Hunter, C. A., L. A. Ellis-Neyes, T. Slifer, S. Kanaly, G. Grunig, M. Fort, D. Rennick, and F. G. Araujo. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J. Immunol. 158: 3311-3316.
23. Ijdo, W. J., W. Sun, Y. Zhang, L. A. Magnarelli, and E. Fikrig. 1998. Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. Infect. Immun. 66:3264-3269.
24. Jahangir, A., C. Kolbert, W. Edwards, P. Mitchell, J. S. Dumler, and D. H. Persing. 1998. Fatal pancarditis associated with human granulocytic ehrlichiosis in 44-year-old man. Clin. Infect. Dis. 27:1424-1427.
25. James, S. L., and J. Glaven. 1989. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J. Immunol. 143:4808-4812.
26. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmanta major induced by tolerance to a single antigen Science 274:421-423.
27. Karupiah, G., Q. W. Xie, R. M. Buller, C. Nathan, C. Duarte, and J. D. MacMicking. 1993. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 261:1445-1448.
28. Kim, H. Y., and Y. Rikihisa. 1998. Characterization of monoclonal antibodies to the 44-kilodalton major outer membrane protein of the human granulocytic ehrlichiosis agent. J. Clin. Microbiol. 36:3278-3284.
29. Luder, C. G., T. Lang, B. Beuerle, and U. Gross. 1998. Down-regulation of MHC class II molecules and inability to up-regulate class I molecules in murine macrophages after infection with Toxoplasma gondii. Clin. Exp. Immunol. 112:308-316.
30. Magnarelli, L. A., J. W. Ijdo, J. Anderson, S. J. Padula, R. A. Flavell, and E. Fikrig. 1998. Human exposure to a granulocytic Ehrlichia and other tickborne agents in Connecticut. J. Clin. Microbiol. 36:2823-2827.
31. Nadelman, R. B., H. W. Horowitz, T. C. Hsieh, J. M. Wu, M. E. Aguero-Rosenfeld, I. Schwartz, J. Nowakowski, S. Varde, and G. P. Wormser. 1997. Simultaneous human granulocytic ehrlichiosis and Lyme borreliosis. N. Engl. J. Med. 337:27-30.
32. Pancoli, P., C. P. Kolbert, P. D. Mitchell, K. D. Reed, Jr., J. S. Dumler, J. S. Bakken, S. R. Telford, and D. H. Persing. 1995. Ixodes dammini as a potential vector of human granulocytic ehrlichiosis. J. Infect. Dis. 172:1007-1012.
33. Petrovec, M., S. L. Furlan, T. A. Zupanc, F. Strle, P. Brouqui, V. Roux, and J. S. Dumler. 1997. Human disease in Europe caused by a granulocytic Ehrlichia species. J. Clin. Microbiol. 35:1556-1559.
34. Pusterla, N., R. Weber, C. Wolfensberger, G. Schar, R. Zbinden, W. Fierz, J. E. Madigan, J. S. Dumler, and H. Lutz. 1998. Serological evidence of human granulocytic ehrlichiosis in Switzerland. Eur. J. Clin. Microbiol. Infect. Dis. 17:207-209.
35. Reiner, S. L., S. Zheng, D. B. Corry, and R. M. Locksley. 1993. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165:37-46.
36. + T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 178:567-577.
37. Scott, P. 1991. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147: 3149-3155.
38. Skeiky, Y. A., M. Kennedy, D. Kaufman, M. M. Borges, J. A. Guderian, J. K. Scholler, P. J. Ovendale, K. S. Picha, P. J. Morrissey, K. H. Grabstein, A. Campos-Neto, and S. G. Reed. 1998. LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile. J. Immunol. 11: 6171-6179.
39. Skeiky, Y. A., J. A. Guderian, D. R. Benson, O. Bacelar, E. M. Carvalho, M. Kubin, R. Badaro, G. Trinchieri, and S. G. Reed. 1995. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J. Exp. Med. 181:1527-1537.
40. Sun, W., J. W. Ijdo, S. R. Telford III, E. Hodzic, Y. Zhang, S. W. Barthold, and E. Fikrig. 1997. Immunization against the agent of human granulocytic ehrlichiosis in a murine model. J. Clin. Investig. 100:3014-3018.
41. Telford, I. S. R., T. J. Lepore, P. Snow, C. K. Warner, and J. E. Dawson. 1995. Human granulocytic ehrlichiosis in Massachusetts. N. Engl. J. Med. 334:209-215.
42. Telford, S. R., III, J. E. Dawson, P. Katavolos, C. K. Warner, C. P. Kolbert, and D. H. Persing. 1996. Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc. Natl. Acad. Sci. USA 93:6209-6214.
43. Wallace, B. J., G. Brady, D. M. Ackman, S. J. Wong, G. Jacquette, E. E. Lloyd, and G. S. Birkhead. 1998. Human granulocytic ehrlichiosis in New York. Arch. Intern. Med. 158:769-773.