Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine

Microbial Cell Factories

Volumn 11, Issue , 2012, Pages

  Peifer, Susanne ^a   Barduhn, Tobias ^a   Zimmet, Sarah ^a   Volmer, Dietrich A ^a   Heinzle, Elmar ^a   Schneider, Konstantin ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Corynebacterium glutamicum; Metabolic engineering; Metabolic flux analysis; Purine accumulation; Targeted metabolomics

Indexed keywords

GLUCOSE 6 PHOSPHATE; HYPOXANTHINE; INOSINE PHOSPHATE; NUCLEOSIDE; PURINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENETICS; BIOSYNTHESIS; CORYNEBACTERIUM GLUTAMICUM; ENZYME METABOLISM; ESCHERICHIA COLI; GENE DELETION; GENETIC ENGINEERING; GLYCOLYSIS; IN VITRO STUDY; INTRACELLULAR SPACE; NONHUMAN; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SALMONELLA TYPHIMURIUM;

BACTERIAL PROTEINS; CARBON CYCLE; CLUSTER ANALYSIS; CORYNEBACTERIUM GLUTAMICUM; GENE DELETION; GENOTYPE; GLUCOSE-6-PHOSPHATE ISOMERASE; HYPOXANTHINE; INOSINE MONOPHOSPHATE; METABOLIC ENGINEERING; MUTAGENESIS, SITE-DIRECTED; PRINCIPAL COMPONENT ANALYSIS; PURINES;

CORYNEBACTERIUM; CORYNEBACTERIUM GLUTAMICUM;

EID: 84867686526     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-11-138     Document Type: Article

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