Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 7, 2012, Pages 2319-2324

  Pang, Bo ^a,c   McFaline, Jose L ^a   Burgis, Nicholas E ^b,d   Dong, Min ^a,e   Taghizadeh, Koli ^a   Sullivan, Matthew R ^a   Elmquist, C Eric ^a,f   Cunningham, Richard P ^b   Dedon, Peter C ^a  

^a Massachusetts Institute of Technology   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c ALNYLAM PHARMACEUTICALS   (United States)

^d EASTERN WASHINGTON UNIVERSITY   (United States)

^e Novartis Pharma AG   (Switzerland)

^f BioMimetic Therapeutics Inc   (United States)

Author keywords

DNA and RNA damage; DNA repair; Mass spectrometry; Nucleobase deamination; Purine metabolism

Indexed keywords

ADENYLOSUCCINATE SYNTHASE; DNA; GENOMIC DNA; GUANOSINE MONOPHOSPHATE SYNTHASE; GUANOSINE PHOSPHATE; HYPOXANTHINE; INOSINATE DEHYDROGENASE; NUCLEIC ACID BASE; PROTEIN; PROTEIN ADE12; PROTEIN HAM1; PROTEIN RDGB; PURINE NUCLEOTIDE; RNA; SYNTHETASE; UNCLASSIFIED DRUG; XANTHINE; XANTHOSINE; XANTHOSINE PHOSPHATE;

ARTICLE; BACTERIAL MUTATION; CONTROLLED STUDY; DEAMINATION; ESCHERICHIA COLI; FUNGUS MUTATION; GENETIC POLYMORPHISM; GENOTYPE; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

DNA; HYPOXANTHINE; PURINE NUCLEOTIDES; RNA; XANTHINE;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 84857136654     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118455109     Document Type: Article

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