Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry

Analytical Chemistry

Volumn 84, Issue 3, 2012, Pages 1294-1301

  Hofmann, Ute ^a   Heinkele, Georg ^a   Angelberger, Sieglinde ^b   Schaeffeler, Elke ^a   Lichtenberger, Cornelia ^b   Jaeger, Simon ^a   Reinisch, Walter ^b   Schwab, Matthias ^a,c  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6-MERCAPTOPURINE; 6-THIOGUANINE; ACTIVE METABOLITES; ADVERSE DRUG REACTIONS; CHEMICAL SYNTHESIS; CYTOTOXIC EFFECTS; IMMUNOSUPPRESSIVE AGENT; INFLAMMATORY BOWEL DISEASE; INTER-ASSAY VARIABILITY; INTERNAL STANDARDS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MOLECULAR MECHANISM; PRODRUGS; RED BLOOD CELL; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; THERAPEUTIC MONITORING;

CYTOTOXICITY; DISEASE CONTROL; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; PATIENT TREATMENT;

NUCLEOTIDES;

6 METHYLTHIOINOSINE; 6-THIOGUANYLIC ACID; AZATHIOPRINE; GUANINE NUCLEOTIDE; IMMUNOSUPPRESSIVE AGENT; MERCAPTOPURINE; NUCLEOTIDE; THIOGUANOSINE PHOSPHATE;

ARTICLE; CHEMISTRY; CROHN DISEASE; ERYTHROCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; METABOLISM; TANDEM MASS SPECTROMETRY;

6-MERCAPTOPURINE; AZATHIOPRINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROHN DISEASE; ERYTHROCYTES; GUANINE NUCLEOTIDES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOTOPE LABELING; METHYLTHIOINOSINE; TANDEM MASS SPECTROMETRY; THIONUCLEOTIDES;

EID: 84856739726     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac2031699     Document Type: Article

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