Paramagnetic Cu(II) for probing membrane protein structure and function: Inhibition mechanism of the influenza M2 proton channel

Journal of the American Chemical Society

Volumn 134, Issue 20, 2012, Pages 8693-8702

  Su, Yongchao ^a   Hu, Fanghao ^a   Hong, Mei ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; FUNCTIONAL LIGANDS; HIGH AFFINITY; HYDROPHOBIC DRUG; INDOLE RINGS; INHIBITION MECHANISMS; KEY RESIDUES; MEMBRANE PROTEIN STRUCTURES; MEMBRANE PROTEINS; N-TERMINALS; NMR STUDIES; NON-SPECIFIC BINDING; NUCLEAR SPIN RELAXATION; PARAMAGNETIC RELAXATION ENHANCEMENTS; PROTEIN RESIDUES; PROTON CHANNELS; PROTON CURRENT; PROTON EXCHANGE; RELAXATION RATES; SPECTRAL BROADENING; STRUCTURAL BASIS; STRUCTURAL PROBES; TRANSMEMBRANE DOMAIN;

AMINES; AMINO ACIDS; BIOLOGICAL MEMBRANES; IONS; LIGANDS; NUCLEAR MAGNETIC RESONANCE; PARAMAGNETISM; PROBES; PROTONS;

PROTEINS;

AMANTADINE; CARBON 13; CATION; COPPER; COPPER ION; HISTIDINE; INDOLE; MEMBRANE PROTEIN; PROTEIN M2; PROTON;

ACCELERATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; CONTROLLED STUDY; INFLUENZA; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; COPPER; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTON PUMPS; VIRAL PROTEINS;

EID: 84861364500     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3026328     Document Type: Article

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