An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 44, 2009, Pages 18775-18779

  Ohigashi, Yuki ^a   Ma, Chunlong ^a   Jing, Xianghong ^a   Balannick, Victoria ^a   Pinto, Lawrence H ^a   Lamb, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Binding site; Inhibition; Proton selective

Indexed keywords

AMANTADINE; ION CHANNEL; RIMANTADINE;

ANTIVIRAL SUSCEPTIBILITY; ARTICLE; BINDING SITE; CHIMERA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; HYDROGEN BOND; INFLUENZA VIRUS A; INFLUENZA VIRUS B; NUCLEAR MAGNETIC RESONANCE; PH MEASUREMENT; PRIORITY JOURNAL;

AMANTADINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; INFLUENZA B VIRUS; ION CHANNEL GATING; ION CHANNELS; MOLECULAR SEQUENCE DATA; MUTATION; RECOMBINANT PROTEINS; VIRAL PROTEINS;

INFLUENZA A VIRUS; INFLUENZA B VIRUS;

EID: 71449123670     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910584106     Document Type: Article

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