-
1
-
-
78649526212
-
Capillary CAA and perivascular Abeta-deposition: two distinct features of Alzheimer's disease pathology
-
Attems J, Yamaguchi H, Saido TC, Thal DR. Capillary CAA and perivascular Abeta-deposition: two distinct features of Alzheimer's disease pathology. J Neurol Sci 2010, 299(1-2):155-162.
-
(2010)
J Neurol Sci
, vol.299
, Issue.1-2
, pp. 155-162
-
-
Attems, J.1
Yamaguchi, H.2
Saido, T.C.3
Thal, D.R.4
-
2
-
-
80054761710
-
Modes of Abeta toxicity in Alzheimer's disease
-
10.1007/s00018-011-0750-2, 3181413, 21706148
-
Gotz J, Eckert A, Matamales M, Ittner LM, Liu X. Modes of Abeta toxicity in Alzheimer's disease. Cellular and molecular life sciences: CMLS 2011, 68(20):3359-3375. 10.1007/s00018-011-0750-2, 3181413, 21706148.
-
(2011)
Cellular and molecular life sciences: CMLS
, vol.68
, Issue.20
, pp. 3359-3375
-
-
Gotz, J.1
Eckert, A.2
Matamales, M.3
Ittner, L.M.4
Liu, X.5
-
3
-
-
0034516988
-
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
-
Selkoe DJ. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 2000, 924:17-25.
-
(2000)
Ann N Y Acad Sci
, vol.924
, pp. 17-25
-
-
Selkoe, D.J.1
-
4
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81(2):741-766.
-
(2001)
Physiol Rev
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
5
-
-
1842728419
-
Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1)
-
10.1007/s00702-003-0095-6, 15057522
-
Blasko I, Beer R, Bigl M, Apelt J, Franz G, Rudzki D, Ransmayr G, Kampfl A, Schliebs R. Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1). J Neural Transm 2004, 111(4):523-536. 10.1007/s00702-003-0095-6, 15057522.
-
(2004)
J Neural Transm
, vol.111
, Issue.4
, pp. 523-536
-
-
Blasko, I.1
Beer, R.2
Bigl, M.3
Apelt, J.4
Franz, G.5
Rudzki, D.6
Ransmayr, G.7
Kampfl, A.8
Schliebs, R.9
-
6
-
-
2142815707
-
Increased beta-secretase activity and expression in rats following transient cerebral ischemia
-
Wen Y, Onyewuchi O, Yang S, Liu R, Simpkins JW. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res 2004, 1009(1-2):1-8.
-
(2004)
Brain Res
, vol.1009
, Issue.1-2
, pp. 1-8
-
-
Wen, Y.1
Onyewuchi, O.2
Yang, S.3
Liu, R.4
Simpkins, J.W.5
-
7
-
-
20944444768
-
Oxidative stress potentiates BACE1 gene expression and Abeta generation
-
10.1007/s00702-004-0255-3, 15614428
-
Tong Y, Zhou W, Fung V, Christensen MA, Qing H, Sun X, Song W. Oxidative stress potentiates BACE1 gene expression and Abeta generation. J Neural Transm 2005, 112(3):455-469. 10.1007/s00702-004-0255-3, 15614428.
-
(2005)
J Neural Transm
, vol.112
, Issue.3
, pp. 455-469
-
-
Tong, Y.1
Zhou, W.2
Fung, V.3
Christensen, M.A.4
Qing, H.5
Sun, X.6
Song, W.7
-
8
-
-
28044458281
-
Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis
-
10.1523/JNEUROSCI.2350-05.2005, 16306400
-
Velliquette RA, O'Connor T, Vassar R. Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. J Neurosci 2005, 25(47):10874-10883. 10.1523/JNEUROSCI.2350-05.2005, 16306400.
-
(2005)
J Neurosci
, vol.25
, Issue.47
, pp. 10874-10883
-
-
Velliquette, R.A.1
O'Connor, T.2
Vassar, R.3
-
9
-
-
33845505233
-
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
-
10.1073/pnas.0606298103, 1693730, 17121991
-
Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, Staufenbiel M, Huang LE, Song W. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci U S A 2006, 103(49):18727-18732. 10.1073/pnas.0606298103, 1693730, 17121991.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.49
, pp. 18727-18732
-
-
Sun, X.1
He, G.2
Qing, H.3
Zhou, W.4
Dobie, F.5
Cai, F.6
Staufenbiel, M.7
Huang, L.E.8
Song, W.9
-
10
-
-
33846523416
-
Beta-Secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity
-
10.1002/cne.21239, 17206602
-
Yan XX, Xiong K, Luo XG, Struble RG, Clough RW. beta-Secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity. J Comp Neurol 2007, 501(1):52-69. 10.1002/cne.21239, 17206602.
-
(2007)
J Comp Neurol
, vol.501
, Issue.1
, pp. 52-69
-
-
Yan, X.X.1
Xiong, K.2
Luo, X.G.3
Struble, R.G.4
Clough, R.W.5
-
11
-
-
79960729002
-
Beta-amyloid precursor protein cleavage enzyme-1 expression in adult rat retinal neurons in the early period after lead exposure
-
Huang JF, Huang K, Shang L, Wang H, Yan XX, Xiong K. Beta-amyloid precursor protein cleavage enzyme-1 expression in adult rat retinal neurons in the early period after lead exposure. Neural Regen Res 2011, 6(14):1045-1051.
-
(2011)
Neural Regen Res
, vol.6
, Issue.14
, pp. 1045-1051
-
-
Huang, J.F.1
Huang, K.2
Shang, L.3
Wang, H.4
Yan, X.X.5
Xiong, K.6
-
12
-
-
34447510973
-
Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina
-
10.1007/s00221-007-0943-y, 17429617
-
Xiong K, Cai H, Luo XG, Struble RG, Clough RW, Yan XX. Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina. Exp Brain Res 2007, 181(3):435-446. 10.1007/s00221-007-0943-y, 17429617.
-
(2007)
Exp Brain Res
, vol.181
, Issue.3
, pp. 435-446
-
-
Xiong, K.1
Cai, H.2
Luo, X.G.3
Struble, R.G.4
Clough, R.W.5
Yan, X.X.6
-
13
-
-
0034643895
-
Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
-
10.1021/bi000169p, 10841777
-
Misonou H, Morishima-Kawashima M, Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry 2000, 39(23):6951-6959. 10.1021/bi000169p, 10841777.
-
(2000)
Biochemistry
, vol.39
, Issue.23
, pp. 6951-6959
-
-
Misonou, H.1
Morishima-Kawashima, M.2
Ihara, Y.3
-
14
-
-
0034673209
-
Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells
-
10.1006/bbrc.2000.2164, 10679257
-
Paola D, Domenicotti C, Nitti M, Vitali A, Borghi R, Cottalasso D, Zaccheo D, Odetti P, Strocchi P, Marinari UM, et al. Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells. Biochem Biophys Res Commun 2000, 268(2):642-646. 10.1006/bbrc.2000.2164, 10679257.
-
(2000)
Biochem Biophys Res Commun
, vol.268
, Issue.2
, pp. 642-646
-
-
Paola, D.1
Domenicotti, C.2
Nitti, M.3
Vitali, A.4
Borghi, R.5
Cottalasso, D.6
Zaccheo, D.7
Odetti, P.8
Strocchi, P.9
Marinari, U.M.10
-
15
-
-
0036403838
-
Oxidative stress increases expression and activity of BACE in NT2 neurons
-
10.1006/nbdi.2002.0515, 12270690
-
Tamagno E, Bardini P, Obbili A, Vitali A, Borghi R, Zaccheo D, Pronzato MA, Danni O, Smith MA, Perry G, et al. Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis 2002, 10(3):279-288. 10.1006/nbdi.2002.0515, 12270690.
-
(2002)
Neurobiol Dis
, vol.10
, Issue.3
, pp. 279-288
-
-
Tamagno, E.1
Bardini, P.2
Obbili, A.3
Vitali, A.4
Borghi, R.5
Zaccheo, D.6
Pronzato, M.A.7
Danni, O.8
Smith, M.A.9
Perry, G.10
-
16
-
-
0036718272
-
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
-
10.1001/archneur.59.9.1381, 12223024
-
Fukumoto H, Cheung BS, Hyman BT, Irizarry MC. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol 2002, 59(9):1381-1389. 10.1001/archneur.59.9.1381, 12223024.
-
(2002)
Arch Neurol
, vol.59
, Issue.9
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
17
-
-
12144286502
-
Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients
-
10.1073/pnas.0205689101, 373514, 14978286
-
Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, et al. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc Natl Acad Sci U S A 2004, 101(10):3632-3637. 10.1073/pnas.0205689101, 373514, 14978286.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.10
, pp. 3632-3637
-
-
Li, R.1
Lindholm, K.2
Yang, L.B.3
Yue, X.4
Citron, M.5
Yan, R.6
Beach, T.7
Sue, L.8
Sabbagh, M.9
Cai, H.10
-
18
-
-
77952005397
-
Advances in studies on saponins in Anemarrhena asphodeloides
-
Ji X, Feng YF. Advances in studies on saponins in Anemarrhena asphodeloides. Chinese Traditional and Herbal Drugs 2010, 41(4):S12-S15.
-
(2010)
Chinese Traditional and Herbal Drugs
, vol.41
, Issue.4
-
-
Ji, X.1
Feng, Y.F.2
-
19
-
-
26944455588
-
A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models
-
Hu Y, Xia Z, Sun Q, Orsi A, Rees D. A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models. Brain Res 2005, 1060(1-2):26-39.
-
(2005)
Brain Res
, vol.1060
, Issue.1-2
, pp. 26-39
-
-
Hu, Y.1
Xia, Z.2
Sun, Q.3
Orsi, A.4
Rees, D.5
-
20
-
-
34250183791
-
Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats
-
10.1016/j.neulet.2007.04.082, 17566650
-
Li TJ, Qiu Y, Yang PY, Rui YC, Chen WS. Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats. Neurosci Lett 2007, 421(2):147-151. 10.1016/j.neulet.2007.04.082, 17566650.
-
(2007)
Neurosci Lett
, vol.421
, Issue.2
, pp. 147-151
-
-
Li, T.J.1
Qiu, Y.2
Yang, P.Y.3
Rui, Y.C.4
Chen, W.S.5
-
21
-
-
70349556534
-
Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells
-
10.1007/s12272-009-1916-4, 19784587
-
Lu WQ, Qiu Y, Li TJ, Tao X, Sun LN, Chen WS. Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells. Arch Pharm Res 2009, 32(9):1301-1308. 10.1007/s12272-009-1916-4, 19784587.
-
(2009)
Arch Pharm Res
, vol.32
, Issue.9
, pp. 1301-1308
-
-
Lu, W.Q.1
Qiu, Y.2
Li, T.J.3
Tao, X.4
Sun, L.N.5
Chen, W.S.6
-
22
-
-
34548084520
-
Effects of timosaponins on learning and memory abilities of rats with dementia induced by lateral cerebral ventricular injection of amyloid beta- peptide
-
Ouyang S, Sun LS, Guo SL, Liu X, Xu JP. Effects of timosaponins on learning and memory abilities of rats with dementia induced by lateral cerebral ventricular injection of amyloid beta- peptide. Di Yi Jun Yi Da Xue Xue Bao 2005, 25(2):121-126.
-
(2005)
Di Yi Jun Yi Da Xue Xue Bao
, vol.25
, Issue.2
, pp. 121-126
-
-
Ouyang, S.1
Sun, L.S.2
Guo, S.L.3
Liu, X.4
Xu, J.P.5
-
23
-
-
58149492754
-
A rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of timosaponin B-II in blood plasma and a study of the pharmacokinetics of saponin in the rat
-
10.1016/j.jpba.2008.09.032, 19027255
-
Cai F, Sun L, Gao S, Yang Y, Yang Q, Chen W. A rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of timosaponin B-II in blood plasma and a study of the pharmacokinetics of saponin in the rat. J Pharm Biomed Anal 2008, 48(5):1411-1416. 10.1016/j.jpba.2008.09.032, 19027255.
-
(2008)
J Pharm Biomed Anal
, vol.48
, Issue.5
, pp. 1411-1416
-
-
Cai, F.1
Sun, L.2
Gao, S.3
Yang, Y.4
Yang, Q.5
Chen, W.6
-
24
-
-
79959744438
-
Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides
-
10.1111/j.1440-1681.2011.05530.x, 21517935
-
Lu WQ, Qiu Y, Li TJ, Tao X, Sun LN, Chen WS. Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides. Clin Exp Pharmacol Physiol 2011, 38(7):430-434. 10.1111/j.1440-1681.2011.05530.x, 21517935.
-
(2011)
Clin Exp Pharmacol Physiol
, vol.38
, Issue.7
, pp. 430-434
-
-
Lu, W.Q.1
Qiu, Y.2
Li, T.J.3
Tao, X.4
Sun, L.N.5
Chen, W.S.6
-
25
-
-
17344385275
-
Clinical features of Alzheimer's disease
-
10.1007/s004060050101, 10653284
-
Forstl H, Kurz A. Clinical features of Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci 1999, 249(6):288-290. 10.1007/s004060050101, 10653284.
-
(1999)
Eur Arch Psychiatry Clin Neurosci
, vol.249
, Issue.6
, pp. 288-290
-
-
Forstl, H.1
Kurz, A.2
-
26
-
-
4544276254
-
Multiple cognitive deficits during the transition to Alzheimer's disease
-
10.1111/j.1365-2796.2004.01386.x, 15324363
-
Backman L, Jones S, Berger AK, Laukka EJ, Small BJ. Multiple cognitive deficits during the transition to Alzheimer's disease. J Intern Med 2004, 256(3):195-204. 10.1111/j.1365-2796.2004.01386.x, 15324363.
-
(2004)
J Intern Med
, vol.256
, Issue.3
, pp. 195-204
-
-
Backman, L.1
Jones, S.2
Berger, A.K.3
Laukka, E.J.4
Small, B.J.5
-
27
-
-
78650673534
-
Ocular biomarkers for early detection of Alzheimer's disease
-
Frost S, Martins RN, Kanagasingam Y. Ocular biomarkers for early detection of Alzheimer's disease. J Alzheimers Dis 2010, 22(1):1-16.
-
(2010)
J Alzheimers Dis
, vol.22
, Issue.1
, pp. 1-16
-
-
Frost, S.1
Martins, R.N.2
Kanagasingam, Y.3
-
28
-
-
78650832181
-
Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model
-
2991559, 20550967
-
Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, Schwartz M, Farkas DL. Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. NeuroImage 2011, 54(Suppl 1):S204-S217. 2991559, 20550967.
-
(2011)
NeuroImage
, vol.54
, Issue.SUPPL. 1
-
-
Koronyo-Hamaoui, M.1
Koronyo, Y.2
Ljubimov, A.V.3
Miller, C.A.4
Ko, M.K.5
Black, K.L.6
Schwartz, M.7
Farkas, D.L.8
-
29
-
-
84863717137
-
Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?
-
Chiu K, Chan TF, Wu A, Leung IY, So KF, Chang RC. Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?. Age (Dordr) 2012, 34(3):633-649.
-
(2012)
Age (Dordr)
, vol.34
, Issue.3
, pp. 633-649
-
-
Chiu, K.1
Chan, T.F.2
Wu, A.3
Leung, I.Y.4
So, K.F.5
Chang, R.C.6
-
30
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, et al. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 2001, 60(8):759-767.
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, Issue.8
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
-
31
-
-
67349279818
-
Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD
-
Reed TT, Pierce WM, Markesbery WR, Butterfield DA. Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. Brain Res 2009, 1274:66-76.
-
(2009)
Brain Res
, vol.1274
, pp. 66-76
-
-
Reed, T.T.1
Pierce, W.M.2
Markesbery, W.R.3
Butterfield, D.A.4
-
32
-
-
75149152568
-
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment
-
Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW, Cohen ML, Wang X, Siedlak SL, Dwyer BE, Hayashi T, et al. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J Alzheimer's Disease: JAD 2010, 19(1):363-372.
-
(2010)
J Alzheimer's Disease: JAD
, vol.19
, Issue.1
, pp. 363-372
-
-
Smith, M.A.1
Zhu, X.2
Tabaton, M.3
Liu, G.4
McKeel, D.W.5
Cohen, M.L.6
Wang, X.7
Siedlak, S.L.8
Dwyer, B.E.9
Hayashi, T.10
-
33
-
-
84856002072
-
Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity
-
10.1371/journal.pone.0028033, 3261865, 22276093
-
Lee HP, Pancholi N, Esposito L, Previll LA, Wang X, Zhu X, Smith MA, Lee HG. Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PLoS One 2012, 7(1):e28033. 10.1371/journal.pone.0028033, 3261865, 22276093.
-
(2012)
PLoS One
, vol.7
, Issue.1
-
-
Lee, H.P.1
Pancholi, N.2
Esposito, L.3
Previll, L.A.4
Wang, X.5
Zhu, X.6
Smith, M.A.7
Lee, H.G.8
-
34
-
-
84861470082
-
Methionine-35 of abeta(1-42): importance for oxidative stress in Alzheimer disease
-
3268025, 22312456
-
Butterfield DA, Sultana R. Methionine-35 of abeta(1-42): importance for oxidative stress in Alzheimer disease. J Amino Acids 2011, 2011:198430. 3268025, 22312456.
-
(2011)
J Amino Acids
, vol.2011
, pp. 198430
-
-
Butterfield, D.A.1
Sultana, R.2
-
35
-
-
84870768980
-
Use of timosaponin Bll in the preparation of a medicament or product for the prevention and treatment of stroke
-
Ma B, Xu Q, Zhao Y, Xiong C, Tan D. Use of timosaponin Bll in the preparation of a medicament or product for the prevention and treatment of stroke. Google Patents 2011,
-
(2011)
Google Patents
-
-
Ma, B.1
Xu, Q.2
Zhao, Y.3
Xiong, C.4
Tan, D.5
-
36
-
-
64949135401
-
Protective effects of timosaponin BII on primary neurons against beta amyloid peptide 25-35
-
Yun D, Bai-ping M, Yu-wen C, Yu-xian S, Jing-jing Z, Yu-jun S. Protective effects of timosaponin BII on primary neurons against beta amyloid peptide 25-35. Chin Pharmacol Bull 2009, 25(2):244-247.
-
(2009)
Chin Pharmacol Bull
, vol.25
, Issue.2
, pp. 244-247
-
-
Yun, D.1
Bai-ping, M.2
Yu-wen, C.3
Yu-xian, S.4
Jing-jing, Z.5
Yu-jun, S.6
|