Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells

Archives of Pharmacal Research

Volumn 32, Issue 9, 2009, Pages 1301-1308

  Lu, Wen Quan ^a   Qiu, Yan ^b   Li, Tie Jun ^c   Tao, Xia ^a   Sun, Lian Na ^a   Chen, Wan Sheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b The 454th Hospital of PLA   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cytokine; MAPK; NF B; Timosaponin B II

Indexed keywords

ANEMARRHENA ASPHODELOIDES EXTRACT; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SAPONIN DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TIMOSAPONIN B II; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG ACTIVITY; ENZYME ACTIVATION; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; REPORTER GENE; WESTERN BLOTTING;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; INTERLEUKIN-1BETA; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SAPONINS; STEROIDS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70349556534     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1916-4     Document Type: Article

References (24)

1. F. C. Barone G. Z. Feuerstein 1999 Inflammatory mediators and stroke: new opportunities for novel therapeutics J. Cereb. Blood Flow. Metab. 19 819 834 10458589 10.1097/00004647-199908000-00001 1:CAS:528:DC%2BD3cXksFSktbk%3D
2. D. Emmanuelle M. Céline O. Stéphanie L. Marie-Josèphe F. Michelle Breuiller 2005 A role for PKCf in the LPS-induced translocation NF-jB p65 subunitin cultured myometrial cells Biochimie 87 513 521 10.1016/j.biochi.2005.02.009 (Pubitemid 40776189)
3. G. Feuerstein X. Wang F. C. Barone 1998 Cytokines in brain ischemia-the role of TNF alpha Cell Mol. Neurobiol. 18 695 701 9876875 10.1023/A: 1020226020062 1:CAS:528:DyaK1MXjtl2gsg%3D%3D (Pubitemid 29012946)
4. K. Frei U. V. Malipiero T. P. Leist R. M. Zinkernagel M. E. Schwab A. Fontana 1989 On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases Eur. J. Immunol. 19 689 694 2543584 10.1002/eji.1830190418 1:CAS:528:DyaL1MXktlOlt7s%3D (Pubitemid 19152937)
5. D. Giulian T. J. Baker L. C. Shih L. B. Lachman 1986 Interleukin 1 of the central nervous system is produced by ameboid microglia J. Exp. Med. 164 594 604 3487617 10.1084/jem.164.2.594 1:CAS:528:DyaL28XltFegsLY%3D
6. A. S. Haqqani M. Nesic E. Preston E. Baumann J. Kelly D. Stanimirovic 2005 Characterization of vascular protein expression patterns in cerebral ischemia/reperfusion using laser capture microdissection and ICAT-nanoLC-MS/MS Faseb. J. 19 1809 1821 16260651 10.1096/fj.05-3793com 1:CAS:528: DC%2BD2MXht1eitbvL (Pubitemid 41598765)
7. G. H. Jeohn C. L. Cooper K. J. Jang B. Liu D. S. Lee H. C. Kim J. S. Hong 2002 Go6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation Neuroscience 114 689 697 12220570 10.1016/S0306-4522(02) 00356-1 1:CAS:528:DC%2BD38Xmsl2gu7Y%3D (Pubitemid 35247655)
8. J. M. Kyriakis J. Avruch 2001 Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Physiol. Rev. 81 807 869 11274345 1:CAS:528:DC%2BD3MXislCrsb8%3D
9. T. J. Li Y. Qiu P. Y. Yang Y. C. Rui W. S. Chen 2007 Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats Neurosci. Lett. 421 147 151 17566650 10.1016/j.neulet.2007.04.082 1:CAS:528:DC%2BD2sXmsFCnsbo%3D (Pubitemid 46907431)
10. T. Liu R. K. Clark P. C. McDonnell P. R. Young R. F. White F. C. Barone G. Z. Feuerstein 1994 Tumor necrosis factor-alpha expression in ischemic neurons Stroke 25 1481 1488 8023366 1:CAS:528:DyaK2cXlsFGmsLc%3D
11. M. P. Mattson S. Camandola 2001 NF-kappaB in neuronal plasticity and neurodegenerative disorders J. Clin. Invest. 107 247 254 11160145 10.1172/JCI11916 1:CAS:528:DC%2BD3MXhtVGitrk%3D
12. P. L. McGeer T. Kawamata D. G. Walker H. Akiyama I. Tooyama E. G. McGeer 1993 Microglia in degenerative neurological disease Glia 7 84 92 8423066 10.1002/glia.440070114 1:STN:280:DyaK3s7jvVOnug%3D%3D
13. A. Nurmi P. J. Lindsberg M. Koistinaho W. Zhang E. Juettler M. L. Karjalainen-Lindsberg F. Weih N. Frank M. Schwaninger J. Koistinaho 2004 Nuclear factorkappaB contributes to infarction after permanent focal ischemia Stroke 35 987 991 14988572 10.1161/01.STR.0000120732.45951.26 (Pubitemid 38419815)
14. H. Offner S. Subramanian S. M. Parker M. E. Afentoulis A. A. Vandenbark P. D. Hurn 2006 Experimental stroke induces massive, rapid activation of the peripheral immune system J. Cereb. Blood. Flow. Metab. 26 654 665 16121126 10.1038/sj.jcbfm.9600217 1:CAS:528:DC%2BD28Xlt1Kjt78%3D
15. L. Pantoni C. Sarti D. Inzitari 1998 Cytokines and cell adhesion molecules in cerebral ischemia: experimental bases and therapeutic perspectives Arterioscler. Thromb. Vasc. Biol. 18 503 513 9555854 1:CAS:528: DyaK1cXis1WrsLo%3D
16. N. J. Rothwell G. N. Luheshi 2000 Interleukin 1 in the brain: biology, pathology and therapeutic target Trends. Neurosci. 23 618 625 11137152 10.1016/S0166-2236(00)01661-1 1:CAS:528:DC%2BD3MXhsVymsA%3D%3D (Pubitemid 32007888)
17. A. Schneider A. Martin-Villalba F. Weih J. Vogel T. Wirth M. Schwaninger 1999 NF-kappaB is activated and promotes cell death in focal cerebral ischemia Nat. Med. 5 554 559 10229233 10.1038/6458 1:CAS:528:DyaK1MXivVKrs7k%3D (Pubitemid 29124351)
18. C. J. Smith H. C. Emsley C. M. Gavin R. F. Georgiou A. Vail E. M. Barberan G. J. del Zoppo J. M. Hallenbeck N. J. Rothwell S. J. Hopkins P. J. Tyrrell 2004 Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome BMC Neurol. 4 2 14725719 10.1186/1471-2377-4-2 (Pubitemid 38729102)
19. D. Stephenson T. Yin E. B. Smalstig M. A. Hsu J. Panetta S. Little J. Clemens 2000 Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia J. Cereb. Blood. Flow. Metab. 20 592 603 10724123 10.1097/00004647-200003000-00017 1:CAS:528:DC%2BD3cXisVegu7Y%3D
20. H. Uno T. Matsuyama H. Akita H. Nishimura M. Sugita 1997 Induction of tumor necrosis factor-alpha in the mouse hippocampus following transient forebrain ischemia J. Cereb. Blood. Flow. Metab. 17 491 499 9183286 10.1097/00004647-199705000-00002 1:CAS:528:DyaK2sXktlajsrc%3D
21. K. M. Walton R. DiRocco B. A. Bartlett E. Koury V. R. Marcy B. Jarvis E. M. Schaefer R. V. Bhat 1998 Activation of p38MAPK in microglia after ischemia J. Neurochem 70 1764 1767 9523596 1:CAS:528:DyaK1cXhvFCqtLs%3D
22. P. L. Wood 1995 Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia Neurol. Res. 17 242 248 7477737 1:CAS:528:DyaK2MXnvV2ksLc%3D
23. C. F. Wu X. L. Bi J. Y. Yang J. Y. Zhan Y. X. Dong J. H. Wang J. M. Wang R. Zhang X. Li 2007 Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia Int. Immunopharmacol. 7 313 320 17276889 10.1016/j.intimp.2006.04.021 1:CAS:528:DC%2BD2sXhtlSlt74%3D (Pubitemid 46186170)
24. Q. G. Zhang R. M. Wang X. H. Yin J. Pan T. L. Xu G. Y. Zhang 2005 Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield J. Neurochem. 95 784 795 16248889 10.1111/j.1471-4159. 2005.03435.x 1:CAS:528:DC%2BD2MXht1SitbjN (Pubitemid 41567170)