Transferability and fine-Mapping of glucose and insulin quantitative trait loci across populations: CARe, the candidate gene association resource

Diabetologia

Volumn 55, Issue 11, 2012, Pages 2970-2984

  Liu, C T ^a   Ng, M C Y ^b   Rybin, D ^c   Adeyemo, A ^d   Bielinski, S J ^e   Boerwinkle, E ^f   Borecki, I ^g   Cade, B ^h   Chen, Y D I ⁱ   Djousse, L ^h,j,k   Fornage, M ^f   Goodarzi, M O ⁱ   Grant, S F A ^l   Guo, X ⁱ   Harris, T ^m   Kabagambe, E ⁿ   Kizer, J R ^o   Liu, Y ^b   Lunetta, K L ^a,p   Mukamal, K ^j   Nettleton, J A ^f   Pankow, J S ^q   Patel, S R ^h   Ramos, E ^d   Rasmussen Torvik, L ^r   Rich, S S ^s   Rotimi, C N ^d   Sarpong, D ^t   Shriner, D ^d   Sims, M ^u   Zmuda, J M ^v   Redline, S ^h   Kao, W H ^w   Siscovick, D ^x   Florez, J C ^j,y,z   Rotter, J I ⁱ   Dupuis, J ^a,p   Wilson, J G ^u   Bowden, D W ^b   Meigs, J B ^j,y   more..

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^e MAYO CLINIC   (United States)

^f UNIVERSITY OF TEXAS   (United States)

^g WASHINGTON UNIVERSITY   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ CEDARS SINAI MEDICAL CENTER   (United States)

^j HARVARD MEDICAL SCHOOL   (United States)

^k VETERANS AFFAIRS MEDICAL CENTER   (United States)

^l CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^m NATIONAL INSTITUTE ON AGING   (United States)

ⁿ UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^o Department of Obstetrics Gynecology   (United States)

^p FRAMINGHAM HEART STUDY   (United States)

^q UNIVERSITY OF MINNESOTA   (United States)

^r NORTHWESTERN UNIVERSITY   (United States)

^s UNIVERSITY OF VIRGINIA   (United States)

^t JACKSON STATE UNIVERSITY   (United States)

^u UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^v UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^w JOHNS HOPKINS UNIVERSITY   (United States)

^x UNIVERSITY OF WASHINGTON   (United States)

^y MASSACHUSETTS GENERAL HOSPITAL   (United States)

^z BROAD INSTITUTE OF MIT AND HARVARD   (United States)

more..

Author keywords

African ancestry; Genetics; Genome wide association; LD mapping; Minorities; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN;

AFRICAN AMERICAN; ARTICLE; CAUCASIAN; COHORT ANALYSIS; CORRELATION ANALYSIS; DIET RESTRICTION; FADS1 GENE; GCK GENE; GCKR GENE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SELECTION; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HUMAN; INSULIN BLOOD LEVEL; MTNR1B GENE; POPULATION GENETICS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; RACE DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; DATABASES, GENETIC; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERGLYCEMIA; INSULIN; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RISK FACTORS; YOUNG ADULT;

EID: 84867580009     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2656-4     Document Type: Article

References (58)

1. Cowie CC, Rust KF, Ford ES et al (2009) Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care 32:287-294
2. Mokdad AH, Bowman BA, Ford ES et al (2001) The continuing epidemics of obesity and diabetes in the United States. JAMA 286:1195-1200
3. Mokdad AH, Ford ES, Bowman BA et al (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289:76-79
4. Myles S, Davison D, Barrett J et al (2008) Worldwide population differentiation at disease-associated SNPs. BMC Med Genome 1:22
5. Guthery SL, Salisbury BA, Pungliya MS et al (2007) The structure of common genetic variation in United States populations. Am J Hum Genet 81:1221-1231
6. Adeyemo A, Rotimi C (2010) Genetic variants associated with complex human diseases show wide variation across multiple populations. Pub Health Genome 13:72-79
7. Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579-589
8. Dupuis J, Langenberg C, Prokopenko I et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105-116
9. Yang Q, Liu T, Shrader P, Yesupriya A et al (2010) Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population. Diabetes Care 33:2370-2377
10. Palmer ND, Hester JM, An SS et al (2011) Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes 60:662-668
11. Casto AM, FeldmanMW, Casto AM et al (2011) Does selection affect unlinked SNPs with shared trait associations? PLoS Genet 7:e1001266
12. Waters KM, Stram DO, Hassanein MT et al (2010) Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet 6:e1001078
13. Lewis JP, Palmer ND, Hicks PJ et al (2008) Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 57:2220-2225
14. Sale MM, Smith SG, Mychaleckyj JC et al (2007) Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes 56:2638-2642
15. Lettre G, Palmer CD, Young Tet al (2011) Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: The NHLBI CARe Project. PLoS Genet 7:e1001300
16. Ioannidis JP, Ntzani EE, Trikalinos TA et al (2004) 'Racial' differences in genetic effects for complex diseases. Nat Genet 36:1312-1318
17. Wilson PW, Meigs JB, Sullivan L et al (2007) Prediction of incident diabetes mellitus in middle-aged adults: The Framingham Offspring Study. Arch Intern Med 167:1068-1074
18. Rasmussen-Torvik LJ, Alonso A, Li M et al (2010) Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose. Genet Epidemiol 34:665-673
19. Ramos E, Chen G, Shriner D et al (2011) Replication of genomewide association studies (GWAS) loci for fasting plasma glucose in African-Americans. Diabetologia 54:783-788
20. The ARIC Investigators (1989) The Atherosclerosis Risk in Communities (ARIC) Study: Design and objectives. The ARIC investigators. Am J Epidemiol 129:687-702
21. Friedman GD, Cutter GR, Donahue RP et al (1988) CARDIA: Study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol 41:1105-1116
22. Buxbaum SG, Elston RC, Tishler PV et al (2002) Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis. Genet Epidemiol 22:243-253
23. Taylor HA Jr,Wilson JG, Jones DWet al (2005) Toward resolution of cardiovascular health disparities in African Americans: Design and methods of the Jackson Heart Study. Ethn Dis 15(S6):4-17
24. Fuqua SR, Wyatt SB, Andrew ME et al (2005) Recruiting African-American research participation in the Jackson Heart Study: Methods, response rates, and sample description. Ethn Dis 15(S6):18-29
25. Wilson JG, Rotimi CN, Ekunwe L et al (2005) Study design for genetic analysis in the Jackson Heart Study. Ethn Dis 15(S6):30-37
26. Taylor HA Jr (2005) The Jackson heart study: An overview. Ethn Dis 15(S6):1-3
27. Bild DE, Bluemke DA, Burke GL et al (2002) Multi-ethnic study of atherosclerosis: Objectives and design. Am J Epidemiol 156:871-881
28. Voight BF, Kudaravalli S, Wen X et al (2006) A map of recent positive selection in the human genome. PLoS Biol 4:e72
29. Ong RT, Teo YY, Ong RT-H et al (2010) varLD: A program for quantifying variation in linkage disequilibrium patterns between populations. Bioinformatics 26:1269-1270
30. Matthews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
31. Willer CJ, Li Y, Abecasis GR. METAL: Fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26:2190-1
32. Zeggini E, Scott LJ, Saxena R et al (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645
33. Zeggini E, Weedon MN, Lindgren CM et al (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341
34. Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345
35. Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
36. Sladek R, Rocheleau G, Rung J et al (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885
37. Li J, Ji L (2005) Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95:221-227
38. Bouatia-Naji N, Bonnefond A, Baerenwald DA et al (2010) Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes 59:2662-2671
39. Yasuda K, Miyake K, Horikawa Yet al (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40:1092-1097
40. Unoki H, Takahashi A, Kawaguchi T et al (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40:1098-1102
41. Sim X, Ong RT, Suo C et al (2011) Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet 7:e1001363
42. Hu C, Zhang R, Wang C et al (2010) Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese. PLoS One 5:e15542
43. Ng MC, Tam CH, So WY et al (2010) Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 95:2418-2425
44. Yamauchi T, Hara K, Maeda S et al (2010) A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 42:864-868
45. Yan Y, North KE, Ballantyne CM et al (2009) Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: The Atherosclerosis Risk in Communities study. Diabetes 58:285-289
46. Dabelea D, Dolan LM, D'Agostino R Jr et al (2011) Association testing of TCF7L2 polymorphisms with type 2 diabetes in multiethnic youth. Diabetologia 54:535-539
47. Grant SF, Li M, Bradfield JP et al (2008) Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One 3:e1746
48. Tishkoff SA, Reed FA, Friedlaender FR et al (2009) The genetic structure and history of Africans and African Americans. Science 324:1035-1044
49. Myles S, Tang K, Somel M et al (2008) Identification and analysis of genomic regions with large between-population differentiation in humans. Ann Hum Genet 72:99-110
50. Martinez-Marignac VL, Valladares A, Cameron E et al (2007) Admixture in Mexico City: Implications for admixture mapping of type 2 diabetes genetic risk factors. Hum Genet 120:807-819
51. Florez JC, Price AL, Campbell D et al (2009) Strong association of socioeconomic status with genetic ancestry in Latinos: Implications for admixture studies of type 2 diabetes. Diabetologia 52:1528-1536
52. McCarthy MI (2008) Casting a wider net for diabetes susceptibility genes. Nat Genet 40:1039-1040
53. Rung J, Cauchi S, Albrechtsen A et al (2009) Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 41:1110-1115
54. Altshuler D, Hirschhorn JN, Klannemark M et al (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80
55. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
56. Gloyn AL, Weedon MN, Owen KR et al (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52:568-572
57. Winckler W, Weedon MN, Graham RR et al (2007) Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 56:685-693
58. Gudmundsson J, Sulem P, Steinthorsdottir V et al (2007) Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 39:977-983