Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the chinese

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Hu, Cheng ^a,b,c   Zhang, Rong ^b,c   Wang, Congrong ^b,c   Wang, Jie ^a,c   Ma, Xiaojing ^b,c   Hou, Xuhong ^b,c   Lu, Jingyi ^b,c   Yu, Weihui ^b,c   Jiang, Feng ^b,c   Bao, Yuqian ^a,c   Xiang, Kunsan ^a,b,c   Jia, Weiping ^a,b,c  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b Shanghai Diabetes Institute   (China)

^c Shanghai Clinical Center of Diabetes   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; CRYPTOCHROME 2; GENE PRODUCT; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; PROTEIN ADCY5; PROTEIN ADRA2A; PROTEIN C2CD4B; PROTEIN DGKB; PROTEIN GIPR; PROTEIN GLIS3; PROTEIN MADD; PROTEIN PROX1; PROTEIN SLC30A8; PROTEIN VPS13C; SOMATOMEDIN C; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG; CATION TRANSPORT PROTEIN; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HOMEODOMAIN PROTEIN; MADD PROTEIN, HUMAN; PROSPERO RELATED HOMEOBOX 1 PROTEIN; PROSPERO-RELATED HOMEOBOX 1 PROTEIN; SLC30A8 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CHINESE; CONTROLLED STUDY; EUROPE; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RACE DIFFERENCE; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; ASIAN; BLOOD; CHINA; ETHNOLOGY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; GLUCOSE TOLERANCE TEST; METABOLISM; METHODOLOGY; MIDDLE AGED;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; CATION TRANSPORT PROTEINS; CHINA; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLUCOSE; GLUCOSE TOLERANCE TEST; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TUMOR SUPPRESSOR PROTEINS;

EID: 78649521990     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015542     Document Type: Article

References (26)

1. Yang W, Lu J, Weng J, Jia W, Ji L, et al. (2010) Prevalence of diabetes among men and women in China. N Engl J Med 362: 1090-1101.
2. Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365: 1333-1346.
3. Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, et al. (2008) A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science 320: 1085-1088.
4. Florez JC (2008) Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. J Clin Endocrinol Metab 93: 4633-4642.
5. Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, et al. (2009) Variants in MTNR1B influence fasting glucose levels. Nat Genet 41: 77-81.
6. Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet 6: e1000847.
7. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42: 105-116.
8. Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, et al. (2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 42: 142-148.
9. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, et al. (2010) Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia 53: 299-308.
10. Hu C, Zhang R, Wang C, Yu W, Lu J, et al. (2010) The effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS ONE 5: e11761.
11. Hu C, Zhang R, Wang C, Ma X, Wang C, et al. (2009) A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population. Diabetologia 52: 451-456.
12. Tam CH, Ho JS, Wang Y, Lee HM, Lam VK, et al. Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS One 5: e11428.
13. Liu C, Wu Y, Li H, Qi Q, Langenberg C, et al. (2010) MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai. BMC Med Genet 11: 59.
14. Ronn T, Wen J, Yang Z, Lu B, Du Y, et al. (2009) A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia 52: 830-833.
15. Jia WP, Pang C, Chen L, Bao YQ, Lu JX, et al. (2007) Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year followup study in Shanghai urban communities. Diabetologia 50: 286-292.
16. Bao Y, Ma X, Li H, Zhou M, Hu C, et al. (2010) Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey. BMJ 340: c2249.
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
18. Stumvoll M, Van Haeften T, Fritsche A, Gerich J (2001) Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. Diabetes Care 24: 796-797.
19. Gutt M, Davis CL, Spitzer SB, Llabre MM, Kumar M, et al. (2000) Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures. Diabetes Res Clin Pract 47: 177-184.
20. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
21. Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, et al. (2010) Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes 59: 1266-1275.
22. Kurada BR, Li LC, Mulherkar N, Subramanian M, Prasad KV, et al. (2009) MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment. J Biol Chem 284: 13533-13541.
23. Scheuner D, Kaufman RJ (2008) The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev 29: 317-333.
24. Torrens JI, Skurnick J, Davidow AL, Korenman SG, Santoro N, et al. (2004) Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women's Health Across the Nation (SWAN). Diabetes Care 27: 354-361.
25. Heni M, Ketterer C, t Hart LM, Ranta F, van Haeften TW, et al. The Impact of Genetic Variation in the G6PC2 Gene on Insulin Secretion Depends on Glycemia. J Clin Endocrinol Metab.
26. Heni M, Ketterer C, Thamer C, Herzberg-Schafer SA, Guthoff M, et al. Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Diabetes.