Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Cellular and Molecular Life Sciences

Volumn 69, Issue 20, 2012, Pages 3511-3527

  Cho, Kyoung In ^a   Searle, Kelly ^a,b   Webb, Mason ^a   Yi, Haiqing ^a   Ferreira, Paulo A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Dopaminergic neurons; Gene environment interaction; Gliosis; Metabolomics; MPTP neurotoxicity; Parkinson; Ran binding protein 2 (RanBP2)

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BRAIN PROTEIN; CHOLESTEROL; EDOXUDINE; FATTY ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; LYSINE; RAN BINDING PROTEIN 2; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

AKINESIA; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN METABOLISM; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CHOLESTEROL METABOLISM; CHROMATIN CONDENSATION; CORPUS STRIATUM; DISEASE MODEL; DOPAMINERGIC NERVE CELL; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; GLIA CELL; GLIOSIS; HAPLOINSUFFICIENCY; MALE; MOUSE; MOUSE STRAIN; MUELLER CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PARKINSONISM; PHENOTYPE; RETINA AMACRINE CELL; RETINA CELL; WILD TYPE;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BRAIN; DOPAMINERGIC NEURONS; HAPLOINSUFFICIENCY; IMMUNOENZYME TECHNIQUES; METABOLOMICS; MICE; MICE, KNOCKOUT; MOLECULAR CHAPERONES; MPTP POISONING; NEUROGLIA; NEUROTOXINS; NUCLEAR PORE COMPLEX PROTEINS; OXIDATIVE STRESS; PARKINSON DISEASE; PHENOTYPE; RETINA; TYROSINE 3-MONOOXYGENASE;

MUS; PARKINSONIA;

EID: 84867572303     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1071-9     Document Type: Article

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