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Volumn 40, Issue 4, 2012, Pages 1438-1448

Naloxone Inhibition of lipopolysaccharide-induced activation of retinal microglia is partly mediated via the p38 mitogen activated protein kinase signalling pathway

Author keywords

Naloxone; Neuroprotection; P38 mapk; Retinal microglia

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; NALOXONE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84867569777     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/147323001204000422     Document Type: Article
Times cited : (11)

References (59)
  • 1
    • 84858017006 scopus 로고    scopus 로고
    • Intercellular (mis)communication in neurodegenerative disease
    • Garden GA, La Spada AR: Intercellular (mis)communication in neurodegenerative disease. Neuron 2012; 73: 886 - 901.
    • (2012) Neuron , vol.73 , pp. 886-901
    • Garden, G.A.1    La Spada, A.R.2
  • 2
    • 34347357758 scopus 로고    scopus 로고
    • Inflammation in Parkinson's diseases and other neurodegenerative diseases: Cause and therapeutic implications
    • Wilms H, Zecca L, Rosenstiel P, et al: Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Curr Pharm Des 2007; 13: 1925 - 1928.
    • (2007) Curr Pharm des , vol.13 , pp. 1925-1928
    • Wilms, H.1    Zecca, L.2    Rosenstiel, P.3
  • 3
    • 33745359291 scopus 로고    scopus 로고
    • Causes of blindness and visual impairment in urban and rural areas in Beijing: The Beijing Eye Study
    • Xu L, Wang Y, Li Y, et al: Causes of blindness and visual impairment in urban and rural areas in Beijing: the Beijing Eye Study. Ophthalmology 2006; 113: 1134el - 1134ell.
    • (2006) Ophthalmology , vol.113
    • Xu, L.1    Wang, Y.2    Li, Y.3
  • 4
    • 84917268726 scopus 로고    scopus 로고
    • Epidemiology of agerelated macular degeneration
    • 4th edn (Ryan SJ, ed). Philadelphia: Elsevier
    • Seddon JM, Chen CA: Epidemiology of agerelated macular degeneration. In: Retina, 4th edn (Ryan SJ, ed). Philadelphia: Elsevier, 2006; pp 1017 - 1028.
    • (2006) Retina , pp. 1017-1028
    • Seddon, J.M.1    Chen, C.A.2
  • 5
    • 84917332024 scopus 로고    scopus 로고
    • Etiologic mechanisms in diabetic retinopathy
    • 4th edn (Ryan SJ, ed). Philadelphia: Elsevier
    • Frank RN: Etiologic mechanisms in diabetic retinopathy. In: Retina, 4th edn (Ryan SJ, ed). Philadelphia: Elsevier, 2006; pp 1241 - 1270.
    • (2006) Retina , pp. 1241-1270
    • Frank, R.N.1
  • 6
    • 84917055945 scopus 로고    scopus 로고
    • Retinitis pigmentosa and allied disorders
    • 4th edn (Ryan SJ, ed). Philadelphia: Elsevier
    • Weleber RG, Gregory-Evans K: Retinitis pigmentosa and allied disorders. In: Retina, 4th edn (Ryan SJ, ed). Philadelphia: Elsevier, 2006; pp 395 - 497.
    • (2006) Retina , pp. 395-497
    • Weleber, R.G.1    Gregory-Evans, K.2
  • 7
    • 66449130960 scopus 로고    scopus 로고
    • Regulation of innate immune responses in the brain
    • Rivest S: Regulation of innate immune responses in the brain. Nat Rev Immunol 2009; 9: 429 - 439.
    • (2009) Nat Rev Immunol , vol.9 , pp. 429-439
    • Rivest, S.1
  • 8
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
    • Block ML, Hong JS: Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005; 76: 77 - 98.
    • (2005) Prog Neurobiol , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 9
    • 59849104241 scopus 로고    scopus 로고
    • Molecular pathology of age-related macular degeneration
    • Ding X, Patel M, Chan CC: Molecular pathology of age-related macular degeneration. Prog Retin Eye Res 2009; 28: 1 18.
    • (2009) Prog Retin Eye Res , vol.28 , pp. 118
    • Ding, X.1    Patel, M.2    Chan, C.C.3
  • 10
    • 34948898131 scopus 로고    scopus 로고
    • CX3CRl-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    • Combadière C, Feumi C, Raoul W, et al: CX3CRl-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. Clin Invest 2007; 117: 2920 - 2928.
    • (2007) Clin Invest , vol.117 , pp. 2920-2928
    • Combadière, C.1    Feumi, C.2    Raoul, W.3
  • 11
    • 0031919598 scopus 로고    scopus 로고
    • Glial reactivity and impaired glutamate metabolism in shortterm experimental diabetic retinopathy. Penn State Retina Research Group
    • Lieth E, Barber AJ, Xu B, et al: Glial reactivity and impaired glutamate metabolism in shortterm experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes 1998; 47: 815 - 820.
    • (1998) Diabetes , vol.47 , pp. 815-820
    • Lieth, E.1    Barber, A.J.2    Xu, B.3
  • 12
    • 0031963497 scopus 로고    scopus 로고
    • Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus
    • Rogove AD, Tsirka SE: Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. Curr Biol 1998; 8: 19-25. (Pubitemid 28056250)
    • (1998) Current Biology , vol.8 , Issue.1 , pp. 19-25
    • Rogove, A.D.1    Tsirka, S.E.2
  • 13
    • 0028867452 scopus 로고
    • Gliadependent neurotoxicity and neuroprotection in mesencephalic cultures
    • Bronstein DM, Perez-Otano I, Sun V, et al: Gliadependent neurotoxicity and neuroprotection in mesencephalic cultures. Brain Res 1995; 704: 112-116.
    • (1995) Brain Res , vol.704 , pp. 112-116
    • Bronstein, D.M.1    Perez-Otano, I.2    Sun, V.3
  • 14
    • 0033021242 scopus 로고    scopus 로고
    • Interferon-y plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus
    • Matsuoka Y, Kitamura Y, Takahashi H, et al: Interferon-y plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus. Neurochem Int 1999; 34: 91 - 99.
    • (1999) Neurochem Int , vol.34 , pp. 91-99
    • Matsuoka, Y.1    Kitamura, Y.2    Takahashi, H.3
  • 15
    • 0031985513 scopus 로고    scopus 로고
    • Microglia as effector cellsin brain damage and repair: Focus on prostanoids and nitric oxide
    • Minghetti L, Levi G: Microglia as effector cellsin brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 1998; 54: 99 - 125.
    • (1998) Prog Neurobiol , vol.54 , pp. 99-125
    • Minghetti, L.1    Levi, G.2
  • 16
    • 0028973428 scopus 로고
    • Modulatory effects of [Met5]-enkephalin on interleukin-1beta secretion from microglia in mixed brain cell cultures
    • DOI 10.1016/0165-5728(95)00083-E
    • Das KP, McMillian MK, Bing G, et al: Modulatory effects of [Met5]-enkephalin on interleukin-lβ secretion from microglia in mixed brain cell cultures. J Neuroimmunol 1995; 62: 9-17. (Pubitemid 3000888)
    • (1995) Journal of Neuroimmunology , vol.62 , Issue.1 , pp. 9-17
    • Das, K.P.1    McMillian, M.K.2    Bing, G.3    Hong, J.-S.4
  • 17
    • 17844392902 scopus 로고    scopus 로고
    • Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    • Krady JK, Basu A, Allen CM, et al: Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 2005; 54: 1559 - 1565.
    • (2005) Diabetes , vol.54 , pp. 1559-1565
    • Krady, J.K.1    Basu, A.2    Allen, C.M.3
  • 18
    • 0033921527 scopus 로고    scopus 로고
    • Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats
    • Zeng XX, Ng YK, Ling EA: Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats. Vis Neurosci 2000; 17: 463 - 471.
    • (2000) Vis Neurosci , vol.17 , pp. 463-471
    • Zeng, X.X.1    Ng, Y.K.2    Ling, E.A.3
  • 19
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
    • Liu B, Hong JS: Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. Pharmacol Exp Ther 2003; 304: 1 - 7.
    • (2003) Pharmacol Exp Ther , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 20
    • 1042278861 scopus 로고    scopus 로고
    • Neuro-glial interactions in the adult rat retina after reaxotomy of ganglion cells: Examination of neuron survival and phagocytic microglia using fluorescent tracers
    • Schuetz E, Thanos S: Neuro-glial interactions in the adult rat retina after reaxotomy of ganglion cells: examination of neuron survival and phagocytic microglia using fluorescent tracers. Brain Res Bull 2004; 62: 391 - 396.
    • (2004) Brain Res Bull , vol.62 , pp. 391-396
    • Schuetz, E.1    Thanos, S.2
  • 21
    • 0027464886 scopus 로고
    • Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro
    • Thanos S, Mey J, Wild M: Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J Neurosci 1993; 13: 455 - 466.
    • (1993) J Neurosci , vol.13 , pp. 455-466
    • Thanos, S.1    Mey, J.2    Wild, M.3
  • 22
    • 0037063691 scopus 로고    scopus 로고
    • GÖ6976 inhibits LPS-induced microglial TNF-a release by suppressing p38 MAP kinase activation
    • Jeohn GH, Cooper CL, Jang KJ, et al: GÖ6976 inhibits LPS-induced microglial TNF-a release by suppressing p38 MAP kinase activation. Neuroscience 2002; 114: 689 - 697.
    • (2002) Neuroscience , vol.114 , pp. 689-697
    • Jeohn, G.H.1    Cooper, C.L.2    Jang, K.J.3
  • 23
    • 0029041510 scopus 로고
    • Molecular biology and pharmacology of cloned opioid receptors
    • Knapp RJ, Malatynska E, Collins N, et al: Molecular biology and pharmacology of cloned opioid receptors. FASEB J 1995; 9: 516 - 525.
    • (1995) FASEB J , vol.9 , pp. 516-525
    • Knapp, R.J.1    Malatynska, E.2    Collins, N.3
  • 24
    • 47249152217 scopus 로고    scopus 로고
    • Neuroprotective effects of naloxone against light-induced photoreceptor degeneration through inhibiting retinal microglial activation
    • Ni YQ Xu GZ, Hu WZ, et al: Neuroprotective effects of naloxone against light-induced photoreceptor degeneration through inhibiting retinal microglial activation. Invest Ophthalmol Vis Sci 2008; 49: 2589 - 2598.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 2589-2598
    • Ni, Y.Q.1    Xu, G.Z.2    Hu, W.Z.3
  • 25
    • 77950858964 scopus 로고    scopus 로고
    • Morphine preconditioning reduces lipopolysaccharide and interferon-y-induced mouse microglial cell injury via 81 opioid receptor activation
    • Gwak MS, Li L, Zuo Z: Morphine preconditioning reduces lipopolysaccharide and interferon-y-induced mouse microglial cell injury via 81 opioid receptor activation. Neuroscience 2010; 167: 256 - 260.
    • (2010) Neuroscience , vol.167 , pp. 256-260
    • Gwak, M.S.1    Li, L.2    Zuo, Z.3
  • 26
    • 72849138642 scopus 로고    scopus 로고
    • Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: Differential involvement of microglia and astroglia
    • Zhang P, Lokuta KM, Turner DE, et al: Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia. J Neurochem 2010; 112: 434 - 443.
    • (2010) J Neurochem , vol.112 , pp. 434-443
    • Zhang, P.1    Lokuta, K.M.2    Turner, D.E.3
  • 27
    • 0034015558 scopus 로고    scopus 로고
    • Naloxone protects rat dopaminergic neurons against inflammatorydamage through inhibition of microglia activation and superoxide generation
    • Liu B, Du L, Hong JS: Naloxone protects rat dopaminergic neurons against inflammatorydamage through inhibition of microglia activation and superoxide generation. J Pharmacol Exp Ther 2000; 293: 607 - 617.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 607-617
    • Liu, B.1    Du, L.2    Hong, J.S.3
  • 28
    • 0030968077 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures
    • Kong LY, McMillian MK, Hudson PM, et al: Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures. J Pharmacol Exp Ther 1997; 280: 61 66.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 6166
    • Kong, L.Y.1    McMillian, M.K.2    Hudson, P.M.3
  • 29
    • 0034072541 scopus 로고    scopus 로고
    • Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia cocultures
    • Liu B, Du L, Kong LY, et al: Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia cocultures. Neuroscience 2000; 97: 749 - 756.
    • (2000) Neuroscience , vol.97 , pp. 749-756
    • Liu, B.1    Du, L.2    Kong, L.Y.3
  • 30
    • 0032928614 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widmann C, Gibson S, Jarpe MB, et al: Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 1999; 79: 143 - 180.
    • (1999) Physiol Rev , vol.79 , pp. 143-180
    • Widmann, C.1    Gibson, S.2    Jarpe, M.B.3
  • 31
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • DOI 10.1126/science.1072682
    • Johnson GL, Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298: 1911-1912. (Pubitemid 35425238)
    • (2002) Science , vol.298 , Issue.5600 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 32
    • 0036803602 scopus 로고    scopus 로고
    • In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance
    • DOI 10.1515/BC.2002.173
    • Shi Y, Gaestel M: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. Biol Chem 2002; 383: 1519-1536. (Pubitemid 35282972)
    • (2002) Biological Chemistry , vol.383 , Issue.10 , pp. 1519-1536
    • Shi, Y.1    Gaestel, M.2
  • 33
    • 38049119409 scopus 로고    scopus 로고
    • P38 MAPK, microglial signaling, and neuropathic pain
    • Ji RR, Suter MR: p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain 2007; 3: 33.
    • (2007) Mol Pain , vol.3 , pp. 33
    • Ji, R.R.1    Suter, M.R.2
  • 34
    • 63349100852 scopus 로고    scopus 로고
    • Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway
    • Tsai RY, Tai YH, Tzeng JI, et al: Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway. Neuroscience 2009; 159: 1244 - 1256.
    • (2009) Neuroscience , vol.159 , pp. 1244-1256
    • Tsai, R.Y.1    Tai, Y.H.2    Tzeng, J.I.3
  • 35
    • 84874192601 scopus 로고    scopus 로고
    • The Association for Research in Vision and Ophthalmology (ARVO): Statement for the Use of Animals in Ophthalmic and Visual Research. Rockville: ARVO available at
    • The Association for Research in Vision and Ophthalmology (ARVO): Statement for the Use of Animals in Ophthalmic and Visual Research. Rockville: ARVO (available at: http://www.arvo.org/Policies/Statement-for-the- Use-of-Animals-in-Ophthalmic-and-Visual- Research/).
  • 36
    • 0033527443 scopus 로고    scopus 로고
    • Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
    • Kumar S, Jiang MS, Adams JL, et al: Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. Biochem Biophys Res Commun 1999; 263: 825 - 831.
    • (1999) Biochem Biophys Res Commun , vol.263 , pp. 825-831
    • Kumar, S.1    Jiang, M.S.2    Adams, J.L.3
  • 37
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson LJ, Perry VH, Dri P, et al: Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990; 39: 151 - 170.
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3
  • 38
    • 0030830310 scopus 로고    scopus 로고
    • Neuroprotection of the optic nerve in glaucoma
    • Caprioli J: Neuroprotection of the optic nerve in glaucoma. Acta Ophthalmol Scand 1997; 75: 364 -367.
    • (1997) Acta Ophthalmol Scand , vol.75 , pp. 364-367
    • Caprioli, J.1
  • 39
    • 0029040685 scopus 로고
    • Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain
    • Giulian D, Haverkamp LJ, Li J, et al: Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochem Int 1995; 27: 119 - 137.
    • (1995) Neurochem Int , vol.27 , pp. 119-137
    • Giulian, D.1    Haverkamp, L.J.2    Li, J.3
  • 40
    • 79960610151 scopus 로고    scopus 로고
    • Activated immune cells in Parkinson's disease
    • Cao JJ, Li KS, Shen YQ: Activated immune cells in Parkinson's disease. Neuroimmune Pharmacol 2011; 6: 323 - 329.
    • (2011) Neuroimmune Pharmacol , vol.6 , pp. 323-329
    • Cao, J.J.1    Li, K.S.2    Shen, Y.Q.3
  • 41
    • 79955971116 scopus 로고    scopus 로고
    • Naloxoneameliorates retinal lesions in Ccl2/Cx3crl double-deficient mice via modulation of microglia
    • Shen D, Cao X, Zhao L, et al: Naloxoneameliorates retinal lesions in Ccl2/Cx3crl double-deficient mice via modulation of microglia. Invest Ophthalmol Vis Sci 2011; 52: 2897 - 2904.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 2897-2904
    • Shen, D.1    Cao, X.2    Zhao, L.3
  • 42
    • 0037375042 scopus 로고    scopus 로고
    • Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration
    • DOI 10.1016/S0014-4835(02)00332-9
    • Gupta N, Brown KE, Milam AH: Activated microglia in human retinitis pigmentosa, lateonset retinal degeneration, and age-related macular degeneration. Exp Eye Res 2003; 76: 463-471. (Pubitemid 36299058)
    • (2003) Experimental Eye Research , vol.76 , Issue.4 , pp. 463-471
    • Gupta, N.1    Brown, K.E.2    Milam, A.H.3
  • 43
    • 0024199439 scopus 로고
    • Functional plasticity of microglia: A review
    • Streit WJ, Graeber MB, Kreutzberg GW: Functional plasticity of microglia: a review. Glia 1988; 1: 301 - 307.
    • (1988) Glia , vol.1 , pp. 301-307
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 44
    • 79960807502 scopus 로고    scopus 로고
    • Microglia: A promising target for treating neuropathic and postoperative pain, and morphine tolerance
    • Wen YR, Tan PH, Cheng JK, et al: Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. / Formos Med Assoc 2011; 110: 487 - 494.
    • (2011) Formos Med Assoc , vol.110 , pp. 487-494
    • Wen, Y.R.1    Tan, P.H.2    Cheng, J.K.3
  • 45
    • 0031013236 scopus 로고    scopus 로고
    • Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats
    • Popovich PG, Wei P, Stokes BT: Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 1997; 377: 443 - 464.
    • (1997) J Comp Neurol , vol.377 , pp. 443-464
    • Popovich, P.G.1    Wei, P.2    Stokes, B.T.3
  • 46
    • 0026702955 scopus 로고
    • Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
    • Boje KM, Arora PK: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 1992; 587: 250 256.
    • (1992) Brain Res , vol.587 , pp. 250256
    • Boje, K.M.1    Arora, P.K.2
  • 47
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao CC, Hu S, Molitor TW, et al: Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 1992; 149: 2736-2741.
    • (1992) J Immunol , vol.149 , pp. 2736-2741
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3
  • 48
    • 0027480439 scopus 로고
    • Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures
    • Dawson VL, Dawson TM, Uhl GR, et al: Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci U S A 1993; 90: 3256 - 3259.
    • (1993) Proc Natl Acad Sci U S a , vol.90 , pp. 3256-3259
    • Dawson, V.L.1    Dawson, T.M.2    Uhl, G.R.3
  • 49
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • Gao HM, Hong JS, Zhang W, et al: Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 2002; 22: 782 - 790.
    • (2002) J Neurosci , vol.22 , pp. 782-790
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3
  • 50
    • 0036845314 scopus 로고    scopus 로고
    • Microglia enhance β-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species
    • Qin L, Liu Y, Cooper C, et al: Microglia enhance β-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J Neurochem 2002; 83: 973 - 983.
    • (2002) J Neurochem , vol.83 , pp. 973-983
    • Qin, L.1    Liu, Y.2    Cooper, C.3
  • 51
    • 20144388634 scopus 로고    scopus 로고
    • Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress
    • Qin L, Block ML, Liu Y, et al: Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J 2005; 19: 550 - 557.
    • (2005) FASEB J , vol.19 , pp. 550-557
    • Qin, L.1    Block, M.L.2    Liu, Y.3
  • 52
    • 77951214647 scopus 로고    scopus 로고
    • Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function
    • Du Y, Tang J, Li G, et al: Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Invest Ophthalmol Vis Sci 2010; 51: 2158 - 2164.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2158-2164
    • Du, Y.1    Tang, J.2    Li, G.3
  • 53
    • 0024545848 scopus 로고
    • Neuronglial relationship during regeneration of motorneurons
    • Kreutzberg GW, Graeber MB, Streit WJ: Neuronglial relationship during regeneration of motorneurons. Metab Brain Dis 1989; 4: 81 - 85.
    • (1989) Metab Brain Dis , vol.4 , pp. 81-85
    • Kreutzberg, G.W.1    Graeber, M.B.2    Streit, W.J.3
  • 54
    • 0028988138 scopus 로고
    • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • Cuenda A, Rouse J, Doza YN, et al: SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995; 364: 229 - 233.
    • (1995) FEBS Lett , vol.364 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3
  • 55
    • 0030918591 scopus 로고    scopus 로고
    • MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEKl, an activator of c-Jun N-terminal kinase/stressactivated protein kinase
    • Hirai S, Katoh M, Terada M, et al: MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEKl, an activator of c-Jun N-terminal kinase/stressactivated protein kinase. J Biol Chem 1997; 272: 15167-15173.
    • (1997) J Biol Chem , vol.272 , pp. 15167-15173
    • Hirai, S.1    Katoh, M.2    Terada, M.3
  • 56
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin
    • Barber AJ, Lieth E, Khin SA, et al: Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest 1998; 102: 783 - 791.
    • (1998) J Clin Invest , vol.102 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khin, S.A.3
  • 57
    • 0032963250 scopus 로고    scopus 로고
    • Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial opticnerve injury
    • Bien A, Seidenbecher CI, Böckers TM, et al: Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial opticnerve injury. J Neurotrauma 1999; 16: 153 - 163.
    • (1999) J Neurotrauma , vol.16 , pp. 153-163
    • Bien, A.1    Seidenbecher, C.I.2    Böckers, T.M.3
  • 58
    • 81755173570 scopus 로고    scopus 로고
    • Role of microglia in CNS inflammation
    • Graeber MB, Li W, Rodriguez ML: Role of microglia in CNS inflammation. FEBS Lett 2011; 585: 3798 - 3805.
    • (2011) FEBS Lett , vol.585 , pp. 3798-3805
    • Graeber, M.B.1    Li, W.2    Rodriguez, M.L.3
  • 59
    • 33847735481 scopus 로고    scopus 로고
    • Naloxone treatment in opioid addiction: The risks and benefits
    • van Dorp EL, Yassen A, Dahan A: Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf 2007; 6: 125 - 132.
    • (2007) Expert Opin Drug Saf , vol.6 , pp. 125-132
    • Van Dorp, E.L.1    Yassen, A.2    Dahan, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.