Epidemiology of Age-Related Macular Degeneration

Retina: Fourth Edition

Volumn 2-3, Issue , 2005, Pages 1017-1027

  Seddon, Johanna M ^a,b   Chen, Clara A ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84917268726     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-323-02598-0.50064-1     Document Type: Chapter

References (180)

1. National Advisory Eye Council (US) Vision research: a national plan 1994-1998. NIH publication no. 93-3186 1993, US Department of Health and Human Services, Bethesda, MD.
2. National Institute for Neurological Diseases and Blindness, Section on Blindness Statistics Statistics on blindness in the model reporting area, 1969-1970. DHEW publication no. (NIH) 73-427. US Department of Health Education, and Welfare 1973, US Government Printing Office, Washington, DC.
3. Age-Related Eye Disease Study Research Group Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11. Arch Ophthalmol 2003, 121:1621-1624.
4. Eye Diseases Prevalence Research Group Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 2004, 122:564-572.
5. Thylefors B A global initiative for the elimination of avoidable blindness. Am J Ophthalmol 1998, 125:90-93.
6. Age-Related Eye Disease Study Research Group A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001, 119:1417-1436.
7. Seddon JM, Hankinson S, Speizer F, et al. A prospective study of smoking and age-related macular degeneration. Am J Epidemiol 1995, 241:136. (abstract).
8. Seddon JM, Willett WC, Speizer FE, et al. A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA 1996, 276:1141-1146.
9. Tomany SC, Wang JJ, van Leeuwen R, et al. Risk factors for incident age-related macular degeneration: pooled findings from three continents. Opthalmology 2004, 111:1280-1287.
10. Cho E, Hung S, Willett WC, et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr 2001, 73:209-218.
11. Cho E, Seddon JM, Rosner B, et al. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol 2004, 122:883-896.
12. Eye Disorders Case-Control Study Group Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol 1993, 111:104-109.
13. Mares-Perlman JA, Brady WE, Klein R Dietary fat and age-related maculopathy. Arch Ophthalmol 1995, 113:743-748.
14. Mares-Perlman JA, Brady WE, Klein R, et al. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch Ophthalmol 1995, 113:1518-1523.
15. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 1994, 272:1413-1420.
16. Seddon JM, Ajani U, Sperduto R, et al. Dietary fat intake and age-related macular degeneration. Invest Ophthalmol Vis Sci 1994, 25:2003.
17. Seddon JM, Hennekens CH Vitamins, minerals, and macular degeneration. Arch Ophthalmol 1994, 112:176-179.
18. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol 2001, 119:1191-1199.
19. Seddon JM, Cote J, Davis N, et al. Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio. Arch Ophthalmol 2003, 21:785-792.
20. Seddon JM, Cote J, Rosner B Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake. Arch Ophthalmol 2003, 121:1728-1737.
21. Seddon JM, Gragoudas E, Egan K Standardized data collection and coding in eye disease epidemiology: the uveal melanoma data system. Ophthalm Surg 1991, 22:127-136.
22. Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol 1995, 39:367-374.
23. Afshari MA, Sharma S, Seddon JM. Evaluation of the clinical age-related maculopathy staging system (CARMS). Presented at the American Academy of Ophthalmology annual meeting, 2000.
24. Age-Related Eye Disease Study Research Group The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1. Control Clin Trials 1999, 20:573-600.
25. Seddon JM, Samelson U, Page WF, et al. Twin study of macular degeneration: methodology and application to genetic epidemiologic studies. Invest Ophthalmol Vis Sci 1996, 38:676.
26. Seddon JM, Santangelo SL, Book K, et al. A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet 2003, 73:780-790.
27. Bressler NM, Bressler SB, West SK, et al. The grading and prevalence of macular degeneration in Chesapeake Bay watermen. Arch Ophthalmol 1989, 107:847-852.
28. Klein R, Davis MD, Magli YL, et al. The Wisconsin age-related maculopathy grading system. Ophthalmology 1991, 98:1128-1134.
29. Ganley J, Roberts J. Eye conditions and related need for medical care among persons 1-74 years of age, United States, 1971-72. Vital and health statistics, series 11, no. 228. DHHS publication no. (PHS) 83-1678. Washington, DC.
30. Klein R, Rowland ML, Harris MI Racial/ethnic differences in age-related maculopathy: third national health and nutrition examination survey. Ophthalmology 1995, 102:371-381.
31. Leibowitz HM, Krueger DE, Maunder LR, et al. The Framingham Eye Study monograph. Surv Ophthalmol 1980, 24:335-610.
32. Klein R, Klein BEK, Linton KLP Prevalence of age-related maculopathy. Ophthalmology 1992, 99:933.
33. Friedman DS, Katz J, Bressler NM, et al. Racial differences in the prevalence of age-related macular degeneration: the Baltimore Eye Survey. Ophthalmology 1999, 106:1049-1055.
34. West SK, Muñoz B, Rubin GS, et al. Function and visual impairment in a population-based study of older adults. The SEE project. Salisbury Eye Evaluation. Invest Ophthalmol Vis Sci 1997, 38:72-82.
35. Vingerling JR, Dielemans I, Hofman A, et al. The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology 1995, 102:205-210.
36. Mitchell P, Smith W, Attebo K, et al. Prevalence of age-related maculopathy in Australia: the Blue Mountains Eye Study. Ophthalmology 1995, 102:1450-1460.
37. Schachat AP, Hyman L, Leske C, et al. Features of age-related macular degeneration in a black population. Arch Ophthalmol 1995, l13:728-735.
38. Pagliarim S, Moramarco A, Wormald RPL, et al. Age-related macular disease in rural southern Italy. Arch Ophthalmol 1997, 115:616-622.
39. National Center for Health Statistics. Plan and operation of the NHANES III: United States 1988-1994. Vital Health Stat vol 1, 1994.
40. Podgor MJ, Leske MC, Ederer F Incidence estimates for lens changes, macular changes, open-angle glaucoma and diabetic retinopathy. Am J Epidemiol 1983, 118:208-212.
41. Klein R, Klein BEK, Jensen SC, et al. The five-year incidence and progression of age-related maculopathy. Ophthalmology 1997, 104:7-21.
42. Mukesh BN, Dimitrov PN, Leikin S, et al. Five-year incidence of age-related maculopathy: The Visual Impairment Project. Ophthalmology 2004, 111:1176-1182.
43. Leske MC, Wu SY, Hyman L, et al. Barbados Eye Studies Group. Four-year incidence of macular changes in the Barbados Eye Studies. Ophthalmology 2004, 111:706-711.
44. Alexander MF, Maguire MG, Lietman TM, et al. Assessment of visual function in patients with age-related macular degeneration and low visual acuity. Arch Ophthalmol 1988, 105:1543-1547.
45. Davis C, Lovie-Kitchin J, Thompson B Psychosocial adjustment to age-related macular degeneration. J Vis Impair Blind 1995, 1:16-27.
46. Mangione CM, Gutierrez P, Lowe G, et al. Influence of age-related maculopathy on visual functioning and health-related quality of life. Am J Ophthalmol 1999, 128:45-53.
47. Age-Related Eye Disease Study Research Group National Eye Institute visual function questionnaire in the Age-Related Eye Disease Study (AREDS). AREDS report no. 10. Arch Ophthalmol 2003, 121:211-217.
48. Brody BL, Gamst AC, Williams RA, et al. Depression, visual acuity, comorbidity, and disability associated with age-related macular degeneration. Ophthalmology 2001, 108:1893-1900. discussion 1900-1901.
49. Casten RJ, Rovner BW, Tasman W Age-related macular degeneration and depression: a review of recent research. Curr Opin Ophthalmol 2004, 15:181-183.
50. Rovner BW, Casten RJ, Tasman WS Effect of depression on vision function in age-related macular degeneration. Arch Ophthalmol 2002, 120:1041-1044.
51. Javitt JC, Zhou Z, Maguire MG, et al. Incidence of exudative age-related macular degeneration among elderly Americans. Ophthalmology 2003, 110:1534-1539.
52. Age-Related Eye Disease Study Research Group Risk factors associated with age-related macular degeneration. A case-control study in the Age-Related Eye Disease Study: AREDS report no. 3. Ophthalmology 2000, 107:2224-2232.
53. Sommer A, Tielsch JM, Katz J, et al. Racial differences in the cause-specific prevalence of blindness in East Baltimore. N Engl J Med 1991, 325:1412-1417.
54. Cruickshanks KJ, Hamman RF, Klein R, et al. The prevalence of age-related maculopathy by geographic region and ethnicity. Arch Ophthalmol 1997, 115:242-250.
55. Varma R, Fraser-Bell S, Tan S, et al. Los Angeles Latino Eye Study Group. Prevalence of age-related macular degeneration in Latinos. Ophthalmology 2004, 111:1288-1297.
56. Oshima Y, Ishibashi T, Murata T, et al. Prevalence of age related maculopathy in a representative Japanese population: the Hisayama study. Br J Ophthalmol 2001, 85:1153-1157.
57. Miyazaki M, Nakamura H, Kubo M, et al. Risk factors for age related maculopathy in a Japanese population: the Hisayama study. Br J Ophthalmol 2003, 87:469-472.
58. Das BN, Thompson JR, Patel R, et al. The prevalence of eye disease in Leicester: a comparison of adults of Asian and European descent. J R Soc Med 1994, 87:219-222.
59. Adler NE, Boyce WT, Chesney MA, et al. Socioeconomic inequalities in health: no easy solution. JAMA 1993, 269:3140-3145.
60. Eye Disease Case-Control Study Group Risk factors for neovascular age-related macular degeneration. Arch Ophthalmol 1992, 110:1701-1708.
61. Klein R, Klein BEK, Jensen SC, et al. The relation of socioeconomic factors to age-related cataract, maculopathy and impaired vision. Ophthalmology 1994, 101:1969-1979.
62. Hyman LG, Lilienfeld AM, Ferris FL, et al. Senile macular degeneration: a case-control study. Am J Epidemiol 1983, 118:213-227.
63. Chaine G, Hullo A, Sahel J, et al. Case-control study of the risk factors for age related macular degeneration. France-DMLA study group. Br J Ophthalmol 1998, 82:996-1002.
64. Maltzman BA, Mulvihill MN, Greenbaum A Senile macular degeneration and risk factors: a case-control study. Ann Ophthalmol 1979, 11:1197-1201.
65. Wang JJ, Mitchell P, Smith W Refractive error and age-related maculopathy: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci 1998, 39:2167-2171.
66. Ikram MK, van Leeuwen R, Vingerling JR, et al. Relationship between refraction and prevalent as well as incident age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci 2003, 44:3778-3782.
67. Friedman E, Ivry M, Ebert E, et al. Increased scleral rigidity and age-related macular degeneration. Ophthalmology 1989, 96:104-108.
68. Frank RN, Puklin JE, Stock C, et al. Race, iris color, and age-related macular degeneration. Trans Am Ophthalmol Soc 2000, 98:109-115.
69. Holz FG, Piguet B, Minassian DC, et al. Decreasing stromal iris pigmentation as a risk factor for age-related macular degeneration. Am J Ophthalmol 1994, 117:19-23.
70. Mitchell P, Smith W, Wang JJ Iris color, skin sun sensitivity, and age-related maculopathy. The Blue Mountains Eye Study. Ophthalmology 1998, 105:1359-1363.
71. Sandberg MA, Gaudio AR, Miller S, et al. Iris pigmentation and extent of disease in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 1994, 35:2734-2740.
72. Weiter JJ, Delori FC, Wing GL, et al. Relationship of senile macular degeneration to ocular pigmentation. Am J Ophthalmol 1985, 99:185-187.
73. Gibson JM, Shaw DE, Rosenthal AR Senile cataract and senile macular degeneration: an investigation into possible risk factors. Trans Ophthalmol Soc UK 1986, 105:463-468.
74. Klein R, Klein BEK, Jensen SC, et al. The relationship between ocular factors to the incidence and progression of age-related maculopathy. Arch Ophthalmol 1998, 116:506-513.
75. Tomany SC, Klein R, Klein BE, et al. The relationship between iris color, hair color, and skin sun sensitivity and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 2003, 110:1576-1633.
76. Wang JJ, Jakobsen K, Smith W, et al. Five-year incidence of age-related maculopathy in relation to iris, skin or hair colour, and skin sun sensitivity: the Blue Mountains Eye Study. Clin Exp Ophthalmol 2003, 31:317-321.
77. West SK, Rosenthal FS, Bressler NM, et al. Exposure to sunlight and other risk factors for age-related macular degeneration. Arch Ophthalmol 1989, 107:875-879.
78. Sperduto R, Hiller R, Seigel D Lens opacities and senile maculopathy. Arch Ophthalmol 1981, 99:1004-1008.
79. Liu IY, White L, LaCroix AZ The association between age-related macular degeneration and lens opacities in the aged. Am J Public Health 1989, 79:765-769.
80. Klein R, Klein BE, Wang Q, et al. Is age-related maculopathy associated with cataracts?. Arch Ophthalmol 1994, 112:191-196.
81. Lundstrom M, Brege KG, Floren I, et al. Cataract surgery and quality of life in patients with age related macular degeneration. Br J Ophthalmol 2002, 86:1330-1335.
82. Freeman EE, Munoz B, West SK, et al. Is there an association between cataract surgery and age-related macular degeneration? Data from three population-based studies. Am J Ophthalmol 2003, 135:849-856.
83. Pollack A, Marcovich A, Bukelman A, et al. Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation. Ophthalmology 1996, 103:1546-1554.
84. Christen WG, Glyim RJ, Manson JE, et al. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA 1996, 276:1147-1151.
85. Klein R, Klein BEK, Franke T The relationship of cardiovascular disease and its risk factors to age-related maculopathy. Ophthalmology 1993, 100:406-414.
86. Klein R, Klein BE, Tomany SC, et al. Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. Am J Epidemiol 2002, 156:589-598.
87. POLA Study Group Smoking and age-related macular degeneration. The POLA study. Pathologies Oculaires Liées à l'Age. Arch Ophthalmol 1998, 116:1031-1035.
88. Suner IJ, Espinosa-Heidmann DG, Marin-Castano ME, et al. Nicotine increases size and severity of experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2004, 45:311-317.
89. Bone RA, Landrum JT, Guerra LH, et al. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J Nutr 2003, 133:992-998.
90. Krinsky NI, Landrum JT, Bone RA Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr 2003, 23:171-201.
91. Hung S, Seddon JM The relationship between nutritional factors and age-related macular degeneration. Preventive medicine: the comprehensive guide for health professionals 1997, Humana Press, Totowa, NJ. A. Bendich, R. Deckelbaum (Eds.).
92. Evereklioglu C, Er H, Doganay S, et al. Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration. Doc Ophthalmol 2003, 106:129-136.
93. Sperduto RD, Ferris FL, Kuriij N Do we have a nutritional treatment for age-related cataract or macular degeneration?. Arch Ophthalmol 1990, 108:1403-1405.
94. Anderson RE, Kretzer FL, Rapp LM Free radicals and ocular disease. Adv Exp Med Biol 1994, 366:73-86.
95. Anderson RE, Rapp LM, Wiegand RD Lipid peroxidation and retinal degeneration. Curr Eye Res 1984, 3:223-227.
96. Young RW Pathophysiology of age-related macular degeneration. Surv Ophthalmol 1987, 31:291-306.
97. Hopley C, Salkeld G, Wang JJ, et al. Cost utility of screening and treatment for early age related macular degeneration with zinc and antioxidants. Br J Ophthalmol 2004, 88:450-454.
98. Richer S, Stiles W, Statkute L, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry 2004, 75:216-230.
99. Gale CR, Hall NF, Phillips DI, et al. Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci 2003, 44:2461-2465.
100. Goldberg J, Flowerdew G, Smith E, et al. Factors associated with age-related macular degeneration: an analysis of data from the first National Health and Nutrition Examination Survey. Am J Epidemiol 1988, 128:700-710.
101. Ajani UA, Willett W, Miller D, et al. Alcohol consumption and neovascular age-related macular degeneration. Am J Epidemiol 1993, 138:646. (abstract).
102. Vinding T, Appleyard M, Nyboe J, et al. Risk factor analysis for atrophic and exudative age-related macular degeneration: an epidemiologic study of 1000 aged individuals. Acta Ophthalmol 1992, 70:66-72.
103. Obisesan TO, Hirsch R, Kosoko O, et al. Moderate wine consumption is associated with decreased odds of developing age-related macular degeneration in NHANES-1. J Am Geriatr Soc 1998, 46:1-7.
104. Seddon JM, Cho E, Stampfer M, et al. Prospective study of alcohol consumption and the risk of age-related macular degeneration. Invest Ophthalmol Vis Sci 1999, 40:568.
105. Smith W, Mitchell P Alcohol intake and age-related maculopathy. Am J Ophthalmol 1996, 122:743-745.
106. Klein BE, Klein R, Lee KE, et al. Measures of obesity and age-related eye diseases. Ophthalm Epidemiol 2001, 8:251-262.
107. POLA Study Group Associations of cardiovascular disease and its risk factors with age-related macular degeneration: the POLA study. Ophthalm Epidemiol 2001, 8:237-249.
108. Schaumberg DA, Christen WG, Hankinson SE, et al. Body mass index and the incidence of visually significant age-related maculopathy in men. Arch Ophthalmol 2001, 119:1259-1265.
109. Smith W, Mitchell P, Leeder SR, et al. Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol 1998, 116:583-587.
110. Cruickshanks KJ, Klein R, Klein BEK Sunlight and age-related macular degeneration: the Beaver Dam Eye Study. Arch Ophthalmol 1993, 111:514-518.
111. Cruickshanks KJ, Klein R, Klein BE, et al. Sunlight and the 5-year incidence of early age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol 2001, 119:246-250.
112. Tomany SC, Cruickshanks KJ, Klein R, et al. Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol 2004, 122:750-757.
113. POLA Study Group Light exposure and the risk of age-related macular degeneration: the Pathologies Oculaires Liées à l'Age (POLA) study. Arch Ophthalmol 2001, 119:1463-1468.
114. Darzins P, Mitchell P, Heller RF Sun exposure and age-related macular degeneration: an Australian case-control study. Ophthalmology 1997, 104:770-776.
115. Klein BEK, Klein R, Jensen SC, et al. Are sex hormones associated with age-related maculopathy in women? The Beaver Dam Eye Study. Trans Am Ophthalmol Soc 1994, 92:289-295.
116. Age-Related Macular Degeneration Risk Factors Study Group Hypertension, cardiovascular disease, and age-related macular degeneration. Arch Ophthalmol 2000, 118:351-358.
117. Wilson HL, Schwartz DM, Bhatt HR, et al. Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. Am J Ophthalmol 2004, 137:615-624.
118. Hall NF, Gale CR, Syddall H, et al. Risk of macular degeneration in users of statins: cross sectional study. Br Med J 2001, 323:375-376.
119. van Leeuwen R, Vingerling JR, Hofman A, et al. Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement. Br Med J 2003, 326:255-256.
120. Hall N, Martyn C Could statins prevent age-related macular degeneration?. Exp Opin Pharmacother 2002, 3:803-807.
121. Seddon JM, Gensler G, Milton RC, et al. Association between C-reactive protein and age-related macular degeneration. JAMA 2004, 291:704-710.
122. Klein R, Klein BE, Jensen SC, et al. Medication use and the 5-year incidence of early age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol 2001, 119:1354-1359.
123. Klein R, Klein BE, Tomany SC, et al. The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 2003, 110:1273-1280.
124. Snow KK, Seddon JM Do age-related macular degeneration and cardiovascular disease share common antecedents?. Ophthalm Epidemiol 1999, 6:125-143.
125. van Leeuwen R, Ikram MK, Vingerling JR, et al. Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci 2003, 44:3771-3777.
126. Vingerling JR, Dielemans I, Bots ML, et al. Age-related macular degeneration is associated with atherosclerosis: the Rotterdam Study. Am J Epidemiol 1995, 142:404-409.
127. Hirvela H, Luukinen H, Laara E, et al. Risk factors of age-related maculopathy in a population 70 years of age or older. Ophthalmology 1996, 103:871-877.
128. Vinding T Age-related macular degeneration: an epidemiological study of 1000 elderly individuals with reference to prevalence, funduscopic findings, visual impairment, and risk factors. Acta Ophthalmol Scand 1995, 21(suppl.):1-32.
129. Sperduto RD, Hiller R Systemic hypertension and age-related macular degeneration in the Framingham Eye Study. Arch Ophthalmol 1986, 104:216-226.
130. Delaney WV, Oates RIP Senile macular degeneration: a preliminary study. Ann Ophthalmol 1982, 14:21-24.
131. Kahn HA, Leibowitz HM, Ganley JP, et al. The Framingham Eye Study. II. Association of ophthalmic pathology with single variables previously measured in the Framingham Heart Study. Am J Epidemiol 1977, 106:33-41.
132. Vidaurri JS, Peter J, Halfon ST, et al. Association between drusen and some of the risk factors for coronary artery disease. Ophthalmologica 1984, 188:243-247.
133. Klein R, Klein BEK, Jensen SC The relation of cardiovascular disease and its risk factors to the 5-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 1997, 104:1804-1812.
134. Klein R, Klein BE, Tomany SC, et al. The relation of retinal microvascular characteristics to age-related eye disease: the Beaver Dam eye study. Am J Ophthalmol 2004, 137:435-444.
135. Macular Photocoagulation Study Group Risk factors for choroidal neovascularization in the second eye of patients with juxtafoveal or subfoveal choroidal neovascularization secondary to age-related macular degeneration. Arch Ophthalmol 1997, 151:741-747.
136. Klein R, Klein BE, Marino EK, et al. Early age-related maculopathy in the cardiovascular health study. Ophthalmology 2003, 110:25-33.
137. van Leeuwen R, Klaver CC, Vingerling JR, et al. Cholesterol and age-related macular degeneration: is there a link?. Am J Ophthalmol 2004, 137:750-752.
138. Heuberger RA, Mares-Perlman JA, Klein R, et al. Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey. Arch Ophthalmol 2001, 119:1833-1838.
139. Friedman E Dietary fat and age-related maculopathy. Arch Ophthalmol 1996, 114:235-236.
140. Klein R, Klein BEK, Moss SE Diabetes, hyperglycemia and age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 1992, 99:1527-1534.
141. Snow KK, Cote J, Yang W, et al. Association between reproductive and hormonal factors and age-related maculopathy in postmenopausal women. Am J Ophthalmol 2002, 134:842-848.
142. Smith W, Mitchell P, Wang JJ Gender oestrogen, hormone replacement and age-related macular degeneration: results from the Blue Mountains Eye Study. Aust NZ J Ophthalmol 1997, 25(suppl.):13-15.
143. POLA Study Group Sex steroids and age-related macular degeneration in older French women: the POLA study. Ann Epidemiol 2004, 14:202-208.
144. Abramov Y, Borik S, Yahalom C, et al. The effect of hormone therapy on the risk for age-related maculopathy in postmenopausal women. Menopause 2004, 11:62-68.
145. Women's Health Initiative Investigators Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002, 288:321-333.
146. Women's Health Initiative Investigators Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003, 349:523-534.
147. Anderson DH, Mullins RF, Hageman GS, et al. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002, 134:411-431.
148. Johnson LV, Leitner WP, Staples MK, et al. Complement activation and inflammatory process in drusen formation and age related macular degeneration. Exp Eye Res 2001, 73:887-896.
149. Mullins RF, Russell SR, Anderson DH, et al. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 2000, 14:835-846.
150. Jonas JB, Kreissig I, Hugger P, et al. Intra-vitreal triamcinolone acetonide for exudative age related macular degeneration. Br J Ophthalmol 2003, 87:462-468.
151. Klaver CC, Wolfs RC, Assink JJ, et al. Genetic risk of age-related maculopathy: population-based familial aggregation study. Arch Ophthalmol 1998, 116:1646-1651.
152. Piguet B, Wells JA, Palmvang IB, et al. Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment. Br J Ophthalmol 1993, 77:400-403.
153. Seddon JM, Ajani UA, Mitchell BD Familial aggregation of age-related maculopathy. Am J Ophthalmol 1997, 123:199-206.
154. Silvestri G, Johnston PB, Hughes AE Is genetic predisposition an important risk factor in age-related macular degeneration?. Eye 1994, 8:564-568.
155. Grizzard SW, Arnett D, Haag SL Twin study of age-related macular degeneration. Ophthalm Epidemiol 2003, 10:315-322.
156. Hammond CJ, Webster AR, Snieder H, et al. Genetic influence on early age-related maculopathy: a twin study. Ophthalmology 2002, 109:730-736.
157. Klein ML, Mauldin WM, Stoumbos VD Heredity and age-related macular degeneration: observations in monozygotic twins. Arch Ophthalmol 1994, 112:932-937.
158. Meyers SM, Greene T, Gutman FA A twin study of age-related macular degeneration. Am J Ophthalmol 1995, 120:757-766.
159. Heiba IM, Elston RIC, Klein BEK, et al. Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genet Epidemiol 1994, 11:51-67.
160. Kenealy SJ, Schmidt S, Agarwal A, et al. Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. Mol Vis 2004, 10:57-61.
161. Abecasis GR, Yashar BM, Zhao Y, et al. Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease. Am J Hum Genet 2004, 74:482-494.
162. Iyengar SK, Song D, Klein BE, et al. Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet 2004, 74:20-39.
163. Schick JH, Iyengar SK, Klein BE, et al. A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet 2003, 72:1412-1424.
164. Weeks DE, Conley YP, Tsai HJ, et al. Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet 2004, 75.
165. Allikmets R, Seddon JM, Bernstein PS, et al. Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathies. Hum Genet 1999, 104:449-453.
166. Allikmets R, Singh N, Sun H, et al. A photoreceptor cell-specific ATh-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 1997, 124:331-343.
167. Baird PN, Guida E, Chu DT, et al. The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 2004, 45:1311-1315.
168. De La Paz MA, Pericak-Vance MA, Lennon F, et al. Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. Invest Ophthalmol Vis Sci 1997, 38:1060-1065.
169. Schmidt S, Klaver C, Saunders A, et al. A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Ophthalm Genet 2002, 23:209-223.
170. Seddon JM, Afshari MA, Sharma S, et al. Assessment of mutations in the Best macular dystrophy (VMD2) gene in patients with adult-onset foveomacular vitelliform dystrophy, age-related maculopathy, and bull's-eye maculopathy. Ophthalmology 2001, 108:2060-2067.
171. Seddon JM, De La Paz M, Clements K, et al. No association between apolipoprotein E and advanced age-related macular degeneration. Am J Hum Genet 1996, 559:388.
172. Sun H, Nathans J Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments. Nat Genet 1997, 17:15-16.
173. Weber BHF, Vogt G, Pruett RC, et al. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. Nat Genet 1994, 8:352-356.
174. Zareparsi S, Reddick AC, Branham KE, et al. Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. Invest Ophthalmol Vis Sci 2004, 45:1306-1310.
175. Weeks DE, Conley YP, Mah TS, et al. A full genome scan for age-related maculopathy. Hum Mol Genet 2000, 9:1329-1349.
176. Weeks DE, Conley YP, Tsai HJ, et al. Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31 and 17q25 regions. Am J Ophthalmol 2001, 132:682-692.
177. Pang CP, Baum L, Chan WM, et al. The apolipoprotein E epsilon4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese. Ophthalmologica 2000, 214:289-291.
178. Souied EH, Benlian P, Amouyel P, et al. The E4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol 1998, 125:353-359.
179. Schultz DW, Klein ML, Humpert AJ, et al. Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Hum Mol Genet 2003, 12:3315-3323.
180. Stone EM, Braun TA, Russell SR, et al. Missense variations in the fibulin 5 gene and age-related macular degeneration. N Engl J Med 2004, 351:346-353.