Age-related disruption of steady-state thymic medulla provokes autoimmune phenotype via perturbing negative selection

Aging and Disease

Volumn 3, Issue 3, 2012, Pages 248-259

  Xia, Jiangyan ^a,b   Wang, Hongjun ^a   Guo, Jianfei ^a,c   Zhang, Zhijie ^a   Coder, Brandon ^a   Su, Dong Ming ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aging; Autoimmunity; Central immunological tolerance; FoxN1 gene; Negative selection; Thymic microstructure

Indexed keywords

ANIMALIA; MUS;

EID: 84867525959     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Article

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