The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells

International Immunology

Volumn 19, Issue 10, 2007, Pages 1201-1211

  Gui, Jingang ^a   Zhu, Xike ^a,b   Dohkan, Junichi ^c   Cheng, Lili ^a   Barnes, Peter F ^a   Su, Dong Ming ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

CCL25; P selectin; Progenitor recruitment; Proliferation and apoptosis; Thymic aging; Thymic epithelial cells

Indexed keywords

ANTIBODY; CHEMOKINE; CHEMOKINE CCL25; PADGEM PROTEIN; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; IMMUNOFLUORESCENCE; KIDNEY CAPSULE; KIDNEY CORTEX; KIDNEY MEDULLA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; THYMOCYTE; THYMUS;

AGING; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CHEMOKINES, CC; EPITHELIAL CELLS; FETUS; HEMATOPOIETIC STEM CELLS; LYMPHOID PROGENITOR CELLS; MICE; MICE, INBRED C57BL; P-SELECTIN; THYMUS GLAND;

EID: 34848922760     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm095     Document Type: Article

References (37)

1. van Ewijk, W., Hollander, G., Terhorst, C. and Wang, B. 2000. Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development 127:1583.
2. Klug, D. B., Carter, C., Crouch, E., Roop, D., Conti, C. J. and Richie, E. R. 1998. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc. Natl Acad. Sci. USA 95:11822.
3. van Ewijk, W., Wang, B., Hollander, G. et al. 1999. Thymic microenvironments, 3-D versus 2-D? Semin. Immunol. 11:57.
4. Blackburn, C. C. and Manley, N. R. 2004. Developing a new paradigm for thymus organogenesis. Nat. Rev. Immunol. 4:278.
5. Anderson, G., Harman, B. C., Hare, K. J. and Jenkinson, E. J. 2000. Microenvironmental regulation of T cell development in the thymus. Semin. Immunol. 12:457.
6. Foss, D. L., Donskoy, E. and Goldschneider, I. 2001. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J. Exp. Med. 193:365.
7. Schwarz, B. A. and Bhandoola, A. 2004. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5:953.
8. Petrie, H. T. 2003. Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus. Nat. Rev. Immunol. 3:859.
9. Takahama, Y. 2006. Journey through the thymus: Stromal guides for T-cell development and selection. Nat. Rev. Immunol. 6:127.
10. Scimone, M. L., Aifantis, I., Apostolou, I., von Boehmer, H. and von Andrian, U. H. 2006. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc. Natl Acad. Sci. USA 103:7006
11. Rossi, F. M., Corbel, S. Y., Merzaban, J. S. et al. 2005. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat. Immunol. 6:626.
12. Wurbel, M. A., Philippe, J. M., Nguyen, C. et al. 2000. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur. J. Immunol. 30:262.
13. Schwarz, B. A., Sambandam, A., Maillard, I., Harman, B. C., Love, P. E. and Bhandoola, A. 2007. Selective thymus settling regulated by cytokine and chemokine receptors. J. Immunol. 178:2008.
14. Li, L., Hsu, H. C., Grizzle, W. E. et al. 2003. Cellular mechanism of thymic involution. Scand. J. Immunol. 57:410.
15. Thoman, M. L. 1995. The pattern of T lymphocyte differentiation is altered during thymic involution. Mech. Ageing Dev. 82:155.
16. Aspinall, R. and Andrew, D. 2000. Thymic atrophy in the mouse is a soluble problem of the thymic environment. Vaccine. 18:1629.
17. Heng, T. S., Goldberg, G. L., Gray, D. H., Sutherland, J. S., Chidgey, A. P. and Boyd, R. L. 2005. Effects of castration on thymocyte development in two different models of thymic involution. J. Immunol. 175:2982.
18. Nasreen, M., Ueno, T., Saito, F. and Takahama, Y. 2003. In vivo treatmeat of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla. J. Immunol. 171:3394.
19. Brelinska, R. 2003. Thymic epithelial cells in age-dependent involution. Microsc. Res. Tech. 62:488.
20. Gray, D. H., Seach, N., Ueno, T. et al. 2006. Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells. Blood 108:3777.
21. Porritt, H. E., Rumfelt, L. L., Tabrizifard, S., Schmitt, T M., Zuniga-Pflucker, J. C. and Petrie, H. T. 2004. Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages. Immunity 20:735.
22. Li, G., Sanders, J. M., Phan, E. T., Ley, K. and Sarembock, I. J. 2005. Arterial macrophages and regenerating endothelial cells empress P-selectin in atherosclerosis-prone apolipoprotein E-deficient mice. Am. J. Pathol. 167:1511.
23. Su, D. M. and Manley, N. R. 2000. Hoxa3 and pax1 transcription factors regulate the ability of fetal thymic epithelial cells to promote thymocyte development. J. Immunol. 164:5753.
24. Su, D. M., Navarre, S., Oh, W. J., Condie, B. G. and Manley, N. R. 2003. A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation. Nat. Immunol. 4:1128.
25. Su, D. M. and Manley, N. R. 2002. Stage-specific changes in fetal thymocyte proliferation during the CD4-8- to CD4+8+ transition in wild type, Rag1-/-, and Hoxa3, Pax1 mutant mice. BMC Immunol. 3:12.
26. Thoman, M. L. 1997. Early steps in T cell development are affected by aging. Cell. Immunol. 178:117.
27. Anderson, G. and Jenkinson, E. J. 2001. Lymphostromal interactions in thymic development and function. Nat. Rev. Immunol. 1:31.
28. Lind, E. F., Prockop, S. E., Porritt, H. E. and Petrie, H. T. 2001. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med. 194:127.
29. Spangrude, G. J. and Scollay, R. 1990. Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny. J. Immunol. 145:3661.
30. Goldschneider, I., Komschlies, K. L. and Greiner, D. L. 1986. Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors. J. Exp. Med. 163:1.
31. Shortman, K., Egerton, M., Spangrude, G. J. and Scollay, R. 1990. The generation and fate of thymocytes. Semin. Immunol. 2:3.
32. Liu, C., Saito, F., Liu, Z. et al. 2006. Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood 108:2531.
33. Bleul, C. C. and Boehm, T. 2000. Chemokines define distinct microenvironments in the developing thymus. Eur. J. Immunol. 30:3371.
34. Chantry, D., Romagnani, P., Raport, C. J. et al. 1999. Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes. Blood 94:1890.
35. Mackall, C. L. and Gress, R. E. 1997. Thymic aging and T-cell regeneration. Immunol. Rev. 160:91.
36. Kurobe, H., Liu, C., Ueno, T. et al. 2006. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity 24:165.
37. Zhu, X., Gui, J., Dohkan, J., Cheng, L., Barnes, P. F. and Su, D. 2007. Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involution. Aging Cell. Vol.6, doi: 10.1111/ j.1474-9726.2007.00325.x.