Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

Blood

Volumn 118, Issue 22, 2011, Pages 5723-5731

  Zook, Erin C ^a   Krishack, Paulette A ^a   Zhang, Shubin ^a   Zeleznik Le, Nancy J ^a   Firulli, Anthony B ^b   Witte, Pamela L ^a   Le, Phong T ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 14; GENOMIC DNA; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FORKHEAD BOX N1; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; EPITHELIUM CELL; FLOW CYTOMETRY; FUNCTIONS OF THE HEMIC, LYMPHATIC AND RETICULOENDOTHELIAL SYSTEMS; GENE OVEREXPRESSION; HISTOLOGY; INVOLUTION; LYMPHOCYTE CLONE; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; THYMOCYTE; THYMOPOIESIS; THYMUS; TRANSGENE; TRANSGENIC MOUSE;

EID: 82155201761     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-03-342097     Document Type: Article

References (31)

1. Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol. 2000;18:529-560. (Pubitemid 30365390)
2. Swain S, Clise-Dwyer K, Haynes L. Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol. 2005;17(5):370-377. (Pubitemid 41058768)
3. Ortman CL, Dittmar KA, Witte PL, Le PT. Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int Immunol. 2002;14(7):813-822. (Pubitemid 34814642)
4. Anderson G, Harman BC, Hare KJ, Jenkinson EJ. Microenvironmental regulation of T cell development in the thymus. Semin Immunol. 2000;12(5):457-464.
5. Adriani M, Martinez-Mir A, Fusco F, et al. Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population. Ann Hum Genet. 2004;68(3):265-268. (Pubitemid 39162739)
6. Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T. New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature. 1994;372(6501):103-107. (Pubitemid 24339492)
7. Su DM, Navarre S, Oh WJ, Condie BG, Manley NR. A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation. Nat Immunol. 2003;4(11):1128-1135. (Pubitemid 37428041)
8. Sun L, Guo J, Brown R, Amagai T, Zhao Y, Su DM. Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution. Aging Cell. 2010;9(3):347-357.
9. Cheng L, Guo J, Sun L, et al. Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem. 2010;285(8):5836-5847.
10. Chen L, Xiao S, Manley NR. Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner. Blood. 2009;113(3):567-574.
11. Corbeaux T, Hess I, Swann JB, Kanzler B, Haas-Assenbaum A, Boehm T. Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage. Proc Natl Acad Sci U S A. 2010;107(38):16613-16618.
12. Min H, Montecino-Rodriguez E, Dorshkind K. Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol. 2004;173(1):245-250. (Pubitemid 38797348)
13. Kvell K, Varecza Z, Bartis D, et al. Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence. PLoS One. 2010;5(5):e10701.
14. Gray DH, Seach N, Ueno T, et al. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood. 2006;108(12):3777-3785. (Pubitemid 44864559)
15. Vassar R, Rosenberg M, Ross S, Tyner A, Fuchs E. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A. 1989;86(5):1563-1567. (Pubitemid 19078943)
16. Bleul CC, Corbeaux T, Reuter A, Fisch P, Monting JS, Boehm T. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature. 2006;441(7096):992-996. (Pubitemid 43980354)
17. Anderson KL, Moore NC, McLoughlin DE, Jenkinson EJ, Owen JJ. Studies on thymic epithelial cells in vitro. Dev Comp Immunol. 1998;22(3):367-377. (Pubitemid 28332174)
18. Rodewald HR. Thymus organogenesis. Annu Rev Immunol. 2008;26:355-388.
19. Balciunaite G, Keller MP, Balciunaite E, et al. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol. 2002;3(11):1102-1108. (Pubitemid 35363665)
20. Cai J, Lee J, Kopan R, Ma L. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol. 2009;326(2):420-430.
21. Patel SR, Gordon J, Mahbub F, Blackburn CC, Manley NR. Bmp4 and noggin expression during early thymus and parathyroid organogenesis. Gene Expr Patterns. 2006;6(8):794-799. (Pubitemid 44334730)
22. Terszowski G, Muller SM, Bleul CC, et al. Evidence for a functional second thymus in mice. Science. 2006;312(5771):284-287.
23. Klug DB, Carter C, Gimenez-Conti IB, Richie ER. Cutting edge: thymocyte-independent and thymocyte- dependent phases of epithelial patterning in the fetal thymus. J Immunol. 2002;169(6):2842-2845. (Pubitemid 35013123)
24. Klug DB, Carter C, Crouch E, Roop D, Conti CJ, Richie ER. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A. 1998;95(20):11822-11827. (Pubitemid 28460498)
25. Prockop SE, Petrie HT. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J Immunol. 2004;173(3):1604-1611. (Pubitemid 38971590)
26. Sambandam A, Maillard I, Zediak VP, et al. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat Immunol. 2005;6(7):663-670. (Pubitemid 41716739)
27. Itoi M, Tsukamoto N, Amagai T. Expression of DII4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus. Int Immunol. 2007;19(2):127-132. (Pubitemid 46179007)
28. Tsukamoto N, Itoi M, Nishikawa M, Amagai T. Lack of delta like 1 and 4 expressions in nude thymus anlages. Cell Immunol. 2005;234(2):77-80. (Pubitemid 41208148)
29. Yang H, Youm YH, Dixit VD. Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J Immunol. 2009;183(5):3040-3052.
30. Gillard GO, Farr AG. Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression. J Immunol. 2006;176(10):5815-5824.
31. Sprent J, Cho JH, Boyman O, Surh CD. T cell homeostasis. Immunol Cell Biol. 2008;86(4):312-319. (Pubitemid 351667989)