Constrained Bonding Environment in the Michaelis Complex of Trypanosoma cruzi Uridine Phosphorylase

Biochemistry

Volumn 51, Issue 34, 2012, Pages 6715-6717

  Silva, Rafael G ^a   Kipp, D Randal ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONDING ENVIRONMENT; EXPERIMENTAL VALUES; ISOTOPE EFFECT; MICHAELIS COMPLEX; QUANTUM CHEMICAL MODELING; SUGAR PUCKER; TRANSITION STATE; TRANSITION STATE STRUCTURE; TRYPANOSOMA CRUZI;

ISOTOPES; PHOSPHORYLATION; QUANTUM CHEMISTRY;

ENZYME ACTIVITY;

SULFATE; URACIL; URIDINE; URIDINE PHOSPHORYLASE;

ARTICLE; CHEMICAL REACTION; COMPLEX FORMATION; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE; GEOMETRY; NONHUMAN; PRIORITY JOURNAL; QUANTUM CHEMISTRY; TRYPANOSOMA CRUZI;

CARBON RADIOISOTOPES; ISOTOPE LABELING; KINETICS; MODELS, CHEMICAL; PROTEIN BINDING; PROTOZOAN PROTEINS; TRITIUM; TRYPANOSOMA CRUZI; URIDINE; URIDINE PHOSPHORYLASE;

EID: 84867513134     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300914     Document Type: Article

References (22)

1. Jencks, W. P. (1987) Catalysis in Chemistry and Enzymology, Chapter 5, Dover Publications, New York.
2. Anderson, V. E. (2005) Arch. Biochem. Biophys. 433, 27-"33.
3. Belasco, J. G., and Knowles, J. R. (1980) Biochemistry 19, 472-477.
4. Andrews, L. D., Deng, H., and Herschlag, D. (2011) J. Am. Chem. Soc. 133, 11621-"11631.
5. Warshel, A., Strajbl, M., Villa, J., and Florian, J. (2000) Biochemistry 39, 14728-"14738.
6. Miller, B. G., Butterfoss, G. L., Short, S. A., and Wolfenden, R. (2001) Biochemistry 40, 6227-"6232.
7. Warshel, A., and Levitt, M. (1976) J. Mol. Biol. 103, 227-"249.
8. Ruszczycky, M. W., and Anderson, V. E. (2006) J. Theor. Biol. 243, 328-"342.
9. Schramm, V. L. (2007) Curr. Opin. Chem. Biol. 11, 529-"536.
10. Zhang, Y., and Schramm, V. L. (2011) Biochemistry 50, 4813-4818.
11. Murkin, A. S., Birck, M. R., Rinaldo-Matthis, A., Wuxian, S., Taylor, E. A., Almo, S. C., and Schramm, V. L. (2007) Biochemistry 46, 5038-"5049.
12. Paege, L. M., and Schlenk, F. (1952) Arch. Biochem. Biophys. 40, 42-"49.
13. Silva, R. G., Vetticatt, M. J., Merino, E. F., Cassera, M. B., and Schramm, V. L. (2011) J. Am. Chem. Soc. 133, 9923-"9931.
14. Silva, R. G., and Schramm, V. L. (2011) Biochemistry 50, 9158-9166.
15. Murkin, A. S., Tyler, P. C., and Schramm, V. L. (2008) J. Am. Chem. Soc. 130, 2166-"2167.
16. Canduri, F., dos Santos, D. M., Silva, R. G., Mendes, M. A., Basso, L. A., Palma, M. S., de Azevedo, W. F., Jr., and Santos, D. S. (2004) Biochem. Biophys. Res. Commun. 313, 907-"914.
17. Birck, M. R., and Schramm, V. L. (2004) J. Am. Chem. Soc. 126, 6882-"6883.
18. Frisch, M. J., et al. (2009) Gaussian 09, revision A.02, Gaussian, Inc., Wallingford, CT.
19. Anisimov, V., and Paneth, P. (1999) J. Math. Chem. 26, 75-"86.
20. Lin, J., and Frey, P. A. (2000) J. Am. Chem. Soc. 122, 11258-11259.
21. Larson, E. T., Mudeppa, D. G., Gillespie, J. R., Mueller, N., Napuli, A. J., Arif, J. A., Ross, J., Arakaki, T. L., Lauricella, A., Detitta, G., Luft, J., Zucker, F., Verlinde, C. L., Fan, E., Van Voorhis, W. C., Buckner, F. S., Rathod, P. K., Hol, W. G., and Merritt, E. A. (2010) J. Mol. Biol. 396, 1244-"1259.
22. Schramm, V. L. (2011) Annu. Rev. Biochem. 80, 703-"732.