Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecipitation/homogenization based on acid-base neutralization

International Journal of Pharmaceutics

Volumn 438, Issue 1-2, 2012, Pages 287-295

  Xu, Ying ^a,b   Liu, Xiaoyi ^c   Lian, Ruyue ^a   Zheng, Siji ^c   Yin, Zongning ^b   Lu, Yi ^a   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c Shanghai Zhongxi Pharmaceutical (Group) Co Ltd   (China)

Author keywords

Acid base neutralization; Aripiprazole; Dissolution; Nanosuspensions; Oral bioavailability; Solubility

Indexed keywords

ACID; ARIPIPRAZOLE; BASE;

ACID BASE BALANCE; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; DRUG STABILITY; FEASIBILITY STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOSUSPENSION; NONHUMAN; PARTICLE SIZE; PH; POWDER DIFFRACTION; PRECIPITATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSPENSION; TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY DIFFRACTION; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIPSYCHOTIC AGENTS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMICAL PRECIPITATION; DOGS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; MALE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; PIPERAZINES; POWDER DIFFRACTION; QUINOLONES; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84867405443     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.09.020     Document Type: Article

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