Improvement of aripiprazole solubility by complexation with (2-hydroxy)propyl-β-cyclodextrin using spray drying technique

AAPS PharmSciTech

Volumn 13, Issue 2, 2012, Pages 623-631

  Mihajlovic, Tijana ^a   Kachrimanis, Kyriakos ^c   Graovac, Adrijana ^a   Djuric, Zorica ^b   Ibric, Svetlana ^b  

^a Research and Development   (Serbia)

^b Faculty of Pharmacy   (Serbia)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

complexation; cyclodextrin; dissolution; physical characterization; spray drying

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ARIPIPRAZOLE; BUFFER; POVIDONE;

AQUEOUS SOLUTION; ARTICLE; COMPLEX FORMATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BINDING; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STORAGE; GRINDING; HYDROGEN BOND; INFRARED SPECTROSCOPY; MOLECULAR DOCKING; PH; PRIORITY JOURNAL; SOLUBILIZATION; SPRAY DRYING; STOICHIOMETRY; THERMAL ANALYSIS; THERMOGRAVIMETRY; WATER CONTENT;

ANTIPSYCHOTIC AGENTS; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; DRUG CARRIERS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PIPERAZINES; POVIDONE; POWDERS; QUINOLONES; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; THERMOGRAVIMETRY; WATER;

EID: 84862869269     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9786-3     Document Type: Article

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