Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: Effects on physicochemical properties

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 71, Issue 1, 2009, Pages 109-116

  Zimmermann, Anne ^a   Millqvist Fureby, Anna ^b   Elema, Michiel Ringkjøbing ^c   Hansen, Tue ^c   Müllertz, Anette ^a   Hovgaard, Lars ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b INSTITUTE FOR SURFACE CHEMISTRY   (Sweden)

^c H LUNDBECK A S   (Denmark)

Author keywords

Antisolvent precipitation; Crystal habit; Dissolution rate; Excipient adsorption; Microcrystals; Particle size; Polymers; Poorly soluble drugs; Surfactants; XPS

Indexed keywords

BENZOFURAN DERIVATIVE; DODECYL SULFATE SODIUM; EXCIPIENT; HYDROXYETHYLCELLULOSE; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; MACROGOL 4000; PIPERIDINE DERIVATIVE; POLIDOCANOL; POLOXAMER; POVIDONE; SIRAMESINE; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; CRYSTAL; DRUG SOLUBILITY; MORPHOLOGY; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER; PRECIPITATION; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; X RAY PHOTOELECTRON SPECTROSCOPY;

ADSORPTION; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; EXCIPIENTS; INDOLES; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYMERS; PRECIPITATION; SOLUBILITY; SPECTRUM ANALYSIS; SPIRO COMPOUNDS; SURFACE-ACTIVE AGENTS;

EID: 57349160561     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.06.014     Document Type: Article

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