In vitro evaluation and pharmacokinetics in dogs of solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating

Planta Medica

Volumn 74, Issue 2, 2008, Pages 126-132

  Sun, Ningyun ^a   Zhang, Xingwang ^a   Lu, Yi ^a   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Asteraceae; Flavonolignans; Fluid bed; Milk thistle; Pharmacokinetics; Silybum marianum; Silymarin; Solid dispersion

Indexed keywords

FLAVONOLIGNAN; POVIDONE; SILIBININ; SILYBUM MARIANUM EXTRACT; SILYMARIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DOG; DRUG BIOAVAILABILITY; DRUG COATING; DRUG FORMULATION; DRUG METABOLISM; DRUG SCREENING; DRUG SOLUBILITY; FLUIDIZED BED; HEAT; HUMIDITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SILYBUM MARIANUM; X RAY DIFFRACTION;

ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; DRUG IMPLANTS; KINETICS; MILK THISTLE; PLANT EXTRACTS; SILYMARIN; SOLUBILITY; THERMODYNAMICS;

ASTERACEAE; CANIS FAMILIARIS; SILYBUM MARIANUM;

EID: 40349116324     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1034294     Document Type: Article

References (26)

1. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998; 93: 139-43
2. Pepping J. Milk thistle: Silybum marianum. Am J Health Syst Pharm 1999; 56: 1195-7
3. Ding TM, Tian SJ, Zhang ZX, Gu DZ, Chen YF, Shi YH et al. Determination of active component in silymarin by RP-LC and LC/MS. J Pharm Biomed Anal 2001; 26: 155-61
4. Kvasnicka F, Bíba B, Sevcík R, Voldrich M, Krátká J. Analysis of the active components of silymarin. J Chromatogr A 2003; 990: 239-45
5. Barzaghi N, Crema F, Gatti G, Pifferi G, Perucca E. Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects. Eur J Drug Metab Pharmacokinet 1990; 15: 333-8
6. Morazzoni P, Magistretti MJ, Giachetti C, Zanolo G. Comparative bioavailability of silipide, a new flavanolignans complex in rats. Eur J Drug Metab Pharmacokinet 1992; 17: 39-44
7. Sekiguchi K, Obi N. Studies on absorption of eutectic mixture. I. A comparation of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem Pharm Bull 1961; 9: 866-72
8. Ford JL. The current status of solid dispersions. Pharm Acta Helv 1986; 61: 69-88
9. Serajuddin ATM. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 1999; 88: 1058-66
10. Sethia S, Squillante E. Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. Int J Pharm 2004; 272: 1-10
11. Weuts I, Kempen D, Verreck G, Decorte A, Heymans K, Peeters J et al. Study of the physicochemical properties and stability of solid dispersions of loperamide and PEG6000 prepared by spray drying. Eur J Pharm Biopharm 2005; 59: 119-26
12. Sun N, Wei X, Wu B, Chen J, Lu Y, Wu W. Enhanced dissolution of silymarin/polyvinylpyrrolidone solid dispersion pellets prepared by a one-step fluid-bed coating technique. Powder Tech 2007; doi: 10.1016/j.powtec.2007.05.029
13. Ho HO, Su HL, Tsai T, Sheu MT. The preparation and characterization of solid dispersions on pellets using a fluidized-bed system. Int J Pharm 1996; 139: 223-9
14. Lu C, Lu Y, Chen J, Zhang W, Wu W. Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system. Eur J Pharm Biopharm 2007; 66: 210-9
15. Mascher H, Kikuta C, Weyhenmeyer R. Diastereomeric separation of free and conjugated silibinin in plasma by reversed phase HPLC after specific extraction. J Liquid Chromatogr 1993; 16: 2777-89
16. Wu W, Wang Y, Que L. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. Eur J Pharm Biopharm 2006; 63: 288-94
17. Karavas E, Ktistis G, Xenakis A, Georgarakis E. Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone. Eur J Pharm Biopharm 2006; 63: 103-14
18. Han YH, Lou HX, Ren DM, Sun LR, Ma B, Jia M. Stereoselective metabolism of silybin diastereoisomers in the glucuronidation process. J Pharm Biomed Anal 2004; 34: 1071-8
19. Emås M, Nyqvist H. Methods of studying aging and stabilization of spray-congealed solid dispersions with carnauba wax. 1. Microcalorimetric investigation. Int J Pharm 2000; 197: 117-27
20. Urbanetz NA. Stabilization of solid dispersions of nimodipine and polyethylene glycol. Eur J Pharm Sci 2006; 28: 67-76
21. Pillay V, Fassihi R. Evaluation and comparison of dissolution data derived from different modified release dosage forms: an alternative method. J Control Release 1998; 55: 45-55
22. Polli JE, Rekhi GS, Augsburger LL, Shah VP. Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets. J Pharm Sci 1997; 86: 690-700
23. Livio S, Seghizzi R, Pifferi G. Diffusion behaviour of IdB 1016 across artificial and biological membranes. 4th European Congress of Biopharmaceutics and Pharmacokinetics Geneva; 1990: 17-9
24. Fillburn CR, Kettenacker R, Griffin DW. Bioavailability of a silybin-phosphatidylcholine complex in dogs. J Vet Pharmacol Ther 2007; 30: 132-8
25. Woo JS, Kim TS, Park JH, Chi SC. Formulation and biopharmaceutical evaluation of silymarin using SMEDDS. Arch Pharm Res 2007; 30: 82-9
26. Xiao YY, Song YM, Chen ZP, Ping QN. Preparation of silymarin proliposome: A new way to increase oral bioavailability of silymarin in beagle dogs. Int J Pharm 2006; 319: 162-8