Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers

Clinical Pharmacology and Therapeutics

Volumn 77, Issue 4, 2005, Pages 259-270

  Rodríguez Antona, Cristina ^a   Jande, Mary ^b   Rane, Anders ^b   Ingelman Sundberg, Magnus ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; LIVER ENZYME;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CELL STRAIN HEK293; CHINESE; CONTROLLED STUDY; DETOXIFICATION; DRUG HYDROXYLATION; EMBRYO; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME METABOLISM; ETHNIC DIFFERENCE; EXON; FETUS; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; LIVER MICROSOME; LIVER MICROSOME METABOLISM; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RESTRICTION MAPPING; SAUDI ARABIA; STATISTICAL SIGNIFICANCE; TANZANIA;

AFRICAN CONTINENTAL ANCESTRY GROUP; ARYL HYDROCARBON HYDROXYLASES; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FETUS; GENE EXPRESSION; HUMANS; LIVER; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOTYPE; POLYMERASE CHAIN REACTION; PREGNANCY; SAUDI ARABIA; TANZANIA;

EID: 16344370634     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2004.11.003     Document Type: Article

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