-
1
-
-
0842312531
-
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
-
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, et al. (2004) Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 14: 1-18.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 1-18
-
-
Nelson, D.R.1
Zeldin, D.C.2
Hoffman, S.M.3
Maltais, L.J.4
Wain, H.M.5
-
2
-
-
0036786382
-
Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA
-
Koch I, Weil R, Wolbold R, Brockmoller J, Hustert E, et al. (2002) Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. Drug Metab Dispos 30: 1108-1114.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1108-1114
-
-
Koch, I.1
Weil, R.2
Wolbold, R.3
Brockmoller, J.4
Hustert, E.5
-
3
-
-
0025333289
-
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
-
Gonzalez FJ, Nebert DW, (1990) Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet 6: 182-186.
-
(1990)
Trends Genet
, vol.6
, pp. 182-186
-
-
Gonzalez, F.J.1
Nebert, D.W.2
-
4
-
-
33751162645
-
Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1
-
Martinez-Jimenez CP, Castell JV, Gomez-Lechon MJ, Jover R, (2006) Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1. Mol Pharmacol 70: 1681-1692.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1681-1692
-
-
Martinez-Jimenez, C.P.1
Castell, J.V.2
Gomez-Lechon, M.J.3
Jover, R.4
-
5
-
-
4644359361
-
Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead
-
Nebert DW, Vesell ES, (2004) Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead. Eur J Pharmacol 500: 267-280.
-
(2004)
Eur J Pharmacol
, vol.500
, pp. 267-280
-
-
Nebert, D.W.1
Vesell, E.S.2
-
6
-
-
0035883992
-
Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity
-
Rodriguez-Antona C, Donato MT, Pareja E, Gomez-Lechon MJ, Castell JV, (2001) Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity. Arch Biochem Biophys 393: 308-315.
-
(2001)
Arch Biochem Biophys
, vol.393
, pp. 308-315
-
-
Rodriguez-Antona, C.1
Donato, M.T.2
Pareja, E.3
Gomez-Lechon, M.J.4
Castell, J.V.5
-
7
-
-
77955147593
-
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
-
Yang X, Zhang B, Molony C, Chudin E, Hao K, et al. (2010) Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res 20: 1020-1036.
-
(2010)
Genome Res
, vol.20
, pp. 1020-1036
-
-
Yang, X.1
Zhang, B.2
Molony, C.3
Chudin, E.4
Hao, K.5
-
8
-
-
34548082616
-
Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver
-
Wortham M, Czerwinski M, He L, Parkinson A, Wan YJ, (2007) Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. Drug Metab Dispos 35: 1700-1710.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1700-1710
-
-
Wortham, M.1
Czerwinski, M.2
He, L.3
Parkinson, A.4
Wan, Y.J.5
-
9
-
-
0032169826
-
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene
-
Li W, Harper PA, Tang BK, Okey AB, (1998) Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. Biochem Pharmacol 56: 599-612.
-
(1998)
Biochem Pharmacol
, vol.56
, pp. 599-612
-
-
Li, W.1
Harper, P.A.2
Tang, B.K.3
Okey, A.B.4
-
10
-
-
2642510760
-
Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
-
Nebert DW, Dalton TP, Okey AB, Gonzalez FJ, (2004) Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 279: 23847-23850.
-
(2004)
J Biol Chem
, vol.279
, pp. 23847-23850
-
-
Nebert, D.W.1
Dalton, T.P.2
Okey, A.B.3
Gonzalez, F.J.4
-
11
-
-
0034606647
-
More about: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
-
Rebbeck TR, (2000) More about: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst 92: 76.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 76
-
-
Rebbeck, T.R.1
-
12
-
-
0034816629
-
Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity
-
Pitarque M, von Richter O, Oke B, Berkkan H, Oscarson M, et al. (2001) Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity. Biochem Biophys Res Commun 284: 455-460.
-
(2001)
Biochem Biophys Res Commun
, vol.284
, pp. 455-460
-
-
Pitarque, M.1
von Richter, O.2
Oke, B.3
Berkkan, H.4
Oscarson, M.5
-
13
-
-
0035071598
-
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
-
Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, et al. (2001) Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 27: 383-391.
-
(2001)
Nat Genet
, vol.27
, pp. 383-391
-
-
Kuehl, P.1
Zhang, J.2
Lin, Y.3
Lamba, J.4
Assem, M.5
-
14
-
-
0037119584
-
Allelic variation in human gene expression
-
Yan H, Yuan W, Velculescu VE, Vogelstein B, Kinzler KW, (2002) Allelic variation in human gene expression. Science 297: 1143.
-
(2002)
Science
, vol.297
, pp. 1143
-
-
Yan, H.1
Yuan, W.2
Velculescu, V.E.3
Vogelstein, B.4
Kinzler, K.W.5
-
15
-
-
34247535959
-
Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance
-
Martin J, Cleak J, Willis-Owen SA, Flint J, Shifman S, (2007) Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Mol Psychiatry 12: 421-422.
-
(2007)
Mol Psychiatry
, vol.12
, pp. 421-422
-
-
Martin, J.1
Cleak, J.2
Willis-Owen, S.A.3
Flint, J.4
Shifman, S.5
-
16
-
-
34548390940
-
In vitro assays fail to predict in vivo effects of regulatory polymorphisms
-
Cirulli ET, Goldstein DB, (2007) In vitro assays fail to predict in vivo effects of regulatory polymorphisms. Hum Mol Genet 16: 1931-1939.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1931-1939
-
-
Cirulli, E.T.1
Goldstein, D.B.2
-
17
-
-
53049101481
-
Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
-
Johnson AD, Zhang Y, Papp AC, Pinsonneault JK, Lim JE, et al. (2008) Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Pharmacogenet Genomics 18: 781-791.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 781-791
-
-
Johnson, A.D.1
Zhang, Y.2
Papp, A.C.3
Pinsonneault, J.K.4
Lim, J.E.5
-
18
-
-
0024445437
-
Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression
-
Ikeya K, Jaiswal AK, Owens RA, Jones JE, Nebert DW, et al. (1989) Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol Endocrinol 3: 1399-1408.
-
(1989)
Mol Endocrinol
, vol.3
, pp. 1399-1408
-
-
Ikeya, K.1
Jaiswal, A.K.2
Owens, R.A.3
Jones, J.E.4
Nebert, D.W.5
-
19
-
-
34547781750
-
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0
-
Tamura K, Dudley J, Nei M, Kumar S, (2007) MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 1596-1599.
-
(2007)
Mol Biol Evol
, vol.24
, pp. 1596-1599
-
-
Tamura, K.1
Dudley, J.2
Nei, M.3
Kumar, S.4
-
20
-
-
0037371120
-
Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression
-
Jung D, Kullak-Ublick GA, (2003) Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression. Hepatology 37: 622-631.
-
(2003)
Hepatology
, vol.37
, pp. 622-631
-
-
Jung, D.1
Kullak-Ublick, G.A.2
-
21
-
-
33746217409
-
Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression
-
Qadri I, Iwahashi M, Kullak-Ublick GA, Simon FR, (2006) Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression. Mol Pharmacol 70: 627-636.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 627-636
-
-
Qadri, I.1
Iwahashi, M.2
Kullak-Ublick, G.A.3
Simon, F.R.4
-
22
-
-
0346251165
-
Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter
-
Uno Y, Sakamoto Y, Yoshida K, Hasegawa T, Hasegawa Y, et al. (2003) Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter. J Hum Genet 48: 594-597.
-
(2003)
J Hum Genet
, vol.48
, pp. 594-597
-
-
Uno, Y.1
Sakamoto, Y.2
Yoshida, K.3
Hasegawa, T.4
Hasegawa, Y.5
-
23
-
-
1842684068
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution
-
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, et al. (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428: 493-521.
-
(2004)
Nature
, vol.428
, pp. 493-521
-
-
Gibbs, R.A.1
Weinstock, G.M.2
Metzker, M.L.3
Muzny, D.M.4
Sodergren, E.J.5
-
24
-
-
33745146903
-
A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes
-
Ueda R, Iketaki H, Nagata K, Kimura S, Gonzalez FJ, et al. (2006) A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes. Mol Pharmacol 69: 1924-1930.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1924-1930
-
-
Ueda, R.1
Iketaki, H.2
Nagata, K.3
Kimura, S.4
Gonzalez, F.J.5
-
25
-
-
0031856787
-
Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations
-
Lasker JM, Wester MR, Aramsombatdee E, Raucy JL, (1998) Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch Biochem Biophys 353: 16-28.
-
(1998)
Arch Biochem Biophys
, vol.353
, pp. 16-28
-
-
Lasker, J.M.1
Wester, M.R.2
Aramsombatdee, E.3
Raucy, J.L.4
-
26
-
-
0037214177
-
Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans
-
Lee CR, Pieper JA, Frye RF, Hinderliter AL, Blaisdell JA, et al. (2003) Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans. J Clin Pharmacol 43: 84-91.
-
(2003)
J Clin Pharmacol
, vol.43
, pp. 84-91
-
-
Lee, C.R.1
Pieper, J.A.2
Frye, R.F.3
Hinderliter, A.L.4
Blaisdell, J.A.5
-
27
-
-
33750547308
-
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles
-
Kumar V, Wahlstrom JL, Rock DA, Warren CJ, Gorman LA, et al. (2006) CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug Metab Dispos 34: 1966-1975.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1966-1975
-
-
Kumar, V.1
Wahlstrom, J.L.2
Rock, D.A.3
Warren, C.J.4
Gorman, L.A.5
-
28
-
-
23944510035
-
The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter
-
Chen Y, Kissling G, Negishi M, Goldstein JA, (2005) The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. J Pharmacol Exp Ther 314: 1125-1133.
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 1125-1133
-
-
Chen, Y.1
Kissling, G.2
Negishi, M.3
Goldstein, J.A.4
-
29
-
-
4444278991
-
The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes
-
Parkinson A, Mudra DR, Johnson C, Dwyer A, Carroll KM, (2004) The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicol Appl Pharmacol 199: 193-209.
-
(2004)
Toxicol Appl Pharmacol
, vol.199
, pp. 193-209
-
-
Parkinson, A.1
Mudra, D.R.2
Johnson, C.3
Dwyer, A.4
Carroll, K.M.5
-
30
-
-
0029064096
-
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
-
Dahl ML, Johansson I, Bertilsson L, Ingelman-Sundberg M, Sjoqvist F, (1995) Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther 274: 516-520.
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 516-520
-
-
Dahl, M.L.1
Johansson, I.2
Bertilsson, L.3
Ingelman-Sundberg, M.4
Sjoqvist, F.5
-
31
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences
-
Sachse C, Brockmoller J, Bauer S, Roots I, (1997) Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 60: 284-295.
-
(1997)
Am J Hum Genet
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmoller, J.2
Bauer, S.3
Roots, I.4
-
32
-
-
20744455857
-
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
-
Gaedigk A, Bhathena A, Ndjountche L, Pearce RE, Abdel-Rahman SM, et al. (2005) Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. Pharmacogenomics J 5: 173-182.
-
(2005)
Pharmacogenomics J
, vol.5
, pp. 173-182
-
-
Gaedigk, A.1
Bhathena, A.2
Ndjountche, L.3
Pearce, R.E.4
Abdel-Rahman, S.M.5
-
33
-
-
23944468839
-
Genome amplification of single sperm using multiple displacement amplification
-
Jiang Z, Zhang X, Deka R, Jin L, (2005) Genome amplification of single sperm using multiple displacement amplification. Nucleic Acids Res 33: e91.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Jiang, Z.1
Zhang, X.2
Deka, R.3
Jin, L.4
|