Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: A possible mechanism and the potential for clinical application

International Journal of Pharmaceutics

Volumn 438, Issue 1-2, 2012, Pages 176-183

  Abu Lila, Amr S ^a,b   Eldin, Noha Essam ^a   Ichihara, Masako ^a   Ishida, Tatsuhiro ^a   Kiwada, Hiroshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b Zagazig University   (Egypt)

Author keywords

ABC phenomenon; Antitumor activity; Apoptosis; Oxaliplatin; PEG coated cationic liposomes; Sequential administration

Indexed keywords

OXALIPLATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG POTENCY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR LOCALIZATION; TUMOR MICROENVIRONMENT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; IMMUNOGLOBULIN M; LIPOSOMES; MALE; MICE; MICE, INBRED C57BL; NEOPLASMS; ORGANOPLATINUM COMPOUNDS; POLYETHYLENE GLYCOLS; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

EID: 84867395616     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.08.030     Document Type: Article

References (40)

1. A. Abu-Lila, T. Suzuki, Y. Doi, T. Ishida, and H. Kiwada Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model J. Control. Release 134 2009 18 25
2. A.S. Abu Lila, Y. Doi, K. Nakamura, T. Ishida, and H. Kiwada Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor J. Control. Release 142 2010 167 173
3. A.S. Abu Lila, S. Kizuki, Y. Doi, T. Suzuki, T. Ishida, and H. Kiwada Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model J. Control. Release 137 2009 8 14
4. R. Adam, D.G. Haller, G. Poston, J.L. Raoul, J.P. Spano, J. Tabernero, and E. Van Cutsem Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer - an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009 Ann. Oncol. 21 2010 1579 1584
5. C. Allen, N. Dos Santos, R. Gallagher, G.N. Chiu, Y. Shu, W.M. Li, S.A. Johnstone, A.S. Janoff, L.D. Mayer, M.S. Webb, and M.B. Bally Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol) Biosci. Rep. 22 2002 225 250
6. T. Asai, S. Miyazawa, N. Maeda, K. Hatanaka, Y. Katanasaka, K. Shimizu, S. Shuto, and N. Oku Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC Cancer Sci. 99 2008 1029 1033
7. G.R. Bartlett Colorimetric assay methods for free and phosphorylated glyceric acids J. Biol. Chem. 234 1959 469 471
8. J. Chen, A. Lin, Z. Chen, W. Wang, T. Zhang, H. Cai, and B. Cai Ammonium sulfate gradient loading of brucine into liposomes: effect of phospholipid composition on entrapment efficiency and physicochemical properties in vitro Drug Dev. Ind. Pharm. 36 2010 245 253
9. J. Chu, and J.M. Gallo Application of microdialysis to characterize drug disposition in tumors Adv. Drug Deliv. Rev. 45 2000 243 253
10. J. Cui, C. Li, C. Wang, Y. Li, L. Zhang, and H. Yang Repeated injection of pegylated liposomal antitumour drugs induces the disappearance of the rapid distribution phase J. Pharm. Pharmacol. 60 2008 1651 1657
11. E.T. Dams, P. Laverman, W.J. Oyen, G. Storm, G.L. Scherphof, J.W. van Der Meer, F.H. Corstens, and O.C. Boerman Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes J. Pharmacol. Exp. Ther. 292 2000 1071 1079
12. J. Dobson Magnetic micro- and nano-particle-based targeting for drug and gene delivery Nanomedicine (Lond.) 1 2006 31 37
13. H. Harashima, Y. Midori, S. Ohshima, K. Yachi, H. Kikuchi, and H. Kiwada Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II) Biopharm. Drug Dispos. 14 1993 595 608
14. C.H. Heldin, K. Rubin, K. Pietras, and A. Ostman High interstitial fluid pressure - an obstacle in cancer therapy Nat. Rev. Cancer 4 2004 806 813
15. S. Hussain, A. Pluckthun, T.M. Allen, and U. Zangemeister-Wittke Antitumor activity of an epithelial cell adhesion molecule targeted nanovesicular drug delivery system Mol. Cancer Ther. 6 2007 3019 3027
16. T. Ishida, K. Atobe, X. Wang, and H. Kiwada Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin- encapsulation and high-dose first injection J. Control. Release 115 2006 251 258
17. T. Ishida, M. Ichihara, X. Wang, and H. Kiwada Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes J. Control. Release 115 2006 243 250
18. T. Ishida, M. Ichihara, X. Wang, K. Yamamoto, J. Kimura, E. Majima, and H. Kiwada Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes J. Control. Release 112 2006 15 25
19. T. Ishida, R. Maeda, M. Ichihara, Y. Mukai, Y. Motoki, Y. Manabe, K. Irimura, and H. Kiwada The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study Cell. Mol. Biol. Lett. 7 2002 286
20. T. Ishihara, M. Takeda, H. Sakamoto, A. Kimoto, C. Kobayashi, N. Takasaki, K. Yuki, K. Tanaka, M. Takenaga, R. Igarashi, T. Maeda, N. Yamakawa, Y. Okamoto, M. Otsuka, T. Ishida, H. Kiwada, Y. Mizushima, and T. Mizushima Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles Pharm. Res. 26 2009 2270 2279
21. R.K. Jain Barriers to drug delivery in solid tumors Sci. Am. 271 1994 58 65
22. S.S. Jensen, T.L. Andresen, J. Davidsen, P. Hoyrup, S.D. Shnyder, M.C. Bibby, J.H. Gill, and K. Jorgensen Secretory phospholipase A2 as a tumor-specific trigger for targeted delivery of a novel class of liposomal prodrug anticancer etherlipids Mol. Cancer Ther. 3 2004 1451 1458
23. H. Koide, T. Asai, K. Hatanaka, S. Akai, T. Ishii, E. Kenjo, T. Ishida, H. Kiwada, H. Tsukada, and N. Oku T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes Int. J. Pharm. 392 2010 218 223
24. G. Kong, R.D. Braun, and M.W. Dewhirst Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size Cancer Res. 60 2000 4440 4445
25. P. Laverman, M.G. Carstens, O.C. Boerman, E.T. Dams, W.J. Oyen, N. van Rooijen, F.H. Corstens, and G. Storm Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection J. Pharmacol. Exp. Ther. 298 2001 607 612
26. C.M. Lee, T. Tanaka, T. Murai, M. Kondo, J. Kimura, W. Su, T. Kitagawa, T. Ito, H. Matsuda, and M. Miyasaka Novel chondroitin sulfate-binding cationic liposomes loaded with cisplatin efficiently suppress the local growth and liver metastasis of tumor cells in vivo Cancer Res. 62 2002 4282 4288
27. Y. Ma, Q. Yang, L. Wang, X. Zhou, Y. Zhao, and Y. Deng Repeated injections of PEGylated liposomal topotecan induces accelerated blood clearance phenomenon in rats Eur. J. Pharm. Sci. 45 2012 539 545
28. H. Maeda, G.Y. Bharate, and J. Daruwalla Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect Eur. J. Pharm. Biopharm. 71 2009 409 419
29. Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res. 46 1986 6387 6392
30. D.Q. McNerny, P.R. Leroueil, and J.R. Baker Understanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticals Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2 2010 249 259
31. K. Morimoto, M. Kondo, K. Kawahara, H. Ushijima, Y. Tomino, M. Miyajima, and J. Kimura Advances in targeting drug delivery to glomerular mesangial cells by long circulating cationic liposomes for the treatment of glomerulonephritis Pharm. Res. 24 2007 946 954
32. S.R. Paliwal, R. Paliwal, G.P. Agrawal, and S.P. Vyas Liposomal nanomedicine for breast cancer therapy Nanomedicine (Lond.) 6 2011 1085 1100
33. S. Strieth, M.E. Eichhorn, B. Sauer, B. Schulze, M. Teifel, U. Michaelis, and M. Dellian Neovascular targeting chemotherapy: encapsulation of paclitaxel in cationic liposomes impairs functional tumor microvasculature Int. J. Cancer 110 2004 117 124
34. W. Sun, W. Zou, G. Huang, A. Li, and N. Zhang Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration J. Drug Target. 16 2008 357 365
35. R. Suzuki, T. Takizawa, Y. Kuwata, M. Mutoh, N. Ishiguro, N. Utoguchi, A. Shinohara, M. Eriguchi, H. Yanagie, and K. Maruyama Effective anti-tumor activity of oxaliplatin encapsulated in transferrin-PEG-liposome Int. J. Pharm. 346 2008 143 150
36. T. Tagami, K. Nakamura, T. Shimizu, T. Ishida, and H. Kiwada Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production J. Control. Release 137 2009 234 240
37. V.P. Torchilin Polymer-coated long-circulating microparticulate pharmaceuticals J. Microencapsul. 15 1998 1 19
38. V.P. Torchilin, and T.S. Levchenko TAT-liposomes: a novel intracellular drug carrier Curr. Protein Pept. Sci. 4 2003 133 140
39. X. Wang, T. Ishida, and H. Kiwada Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes J. Control. Release 119 2007 236 244
40. C. Yang, H.Z. Liu, Z.X. Fu, and W.D. Lu Oxaliplatin long-circulating liposomes improved therapeutic index of colorectal carcinoma BMC Biotechnol. 11 2011 21