Genomic analysis of a hybridoma batch cell culture metabolic status in a standard laboratory 5 L bioreactor

Biotechnology Progress

Volumn 28, Issue 5, 2012, Pages 1126-1137

  Kondragunta, Bhargavi ^a,b   Han, Jing ^b   Joshi, Bharat H ^b   Brorson, Kurt A ^c   Puri, Raj K ^b   Uplekar, Shaunak ^a   Moreira, Antonio R ^a   Rao, Govind ^a  

^a Baltimore County   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Cell culture; Genomic; Sparged bioreactor, microarrays; Time course

Indexed keywords

BATCH CULTURE; BIOREACTOR CULTURES; CELLULAR FUNCTION; CELLULAR METABOLISM; CHAIN REACTION; DNA DAMAGE RESPONSE; EARLY-EXPONENTIAL PHASE; EARLY-TO-LATE; GENE EXPRESSION PROFILES; GENE TRANSCRIPTS; GENOMIC; GENOMIC ANALYSIS; OLIGONUCLEOTIDE MICROARRAY; OXIDATIVE STRESS RESPONSE; STATIONARY PHASE; TIME-COURSE; TRANSCRIPTOMICS;

BATCH CELL CULTURE; BIOCONVERSION; BIOREACTORS; CELL CULTURE; CELL DEATH; GENE EXPRESSION; MICROARRAYS; OLIGONUCLEOTIDES; POLYMERASE CHAIN REACTION;

QUALITY CONTROL;

PROTEIN;

ANIMAL; ARTICLE; BATCH CELL CULTURE; BIOREACTOR; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; GENOMICS; HYBRIDOMA; INSTRUMENTATION; METABOLISM; MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; GENE EXPRESSION PROFILING; GENOMICS; HYBRIDOMAS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84867365377     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1605     Document Type: Article

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