The effect of dissolved oxygen on the production and the glycosylation profile of recombinant human erythropoietin produced from CHO cells

Biotechnology and Bioengineering

Volumn 94, Issue 3, 2006, Pages 481-494

  Restelli, Veronica ^a   Wang, Ming Dong ^a   Huzel, Norman ^a   Ethier, Martin ^a   Perreault, Helene ^a   Butler, Michael ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

CHO cells; Erythropoietin; Glycosylation

Indexed keywords

DISSOLVED OXYGEN SENSORS; GENES; GROWTH KINETICS; ION EXCHANGE; MASS SPECTROMETRY; MOLECULAR WEIGHT; TISSUE CULTURE;

BATCH CULTURES; CHINESE HAMSTER OVARY (CHO) CELLS; ERYTHROPOIETIN; GLYCOSYLATION;

BIOMEDICAL ENGINEERING;

DISSOLVED OXYGEN; GLYCOSYLATED PROTEIN; RECOMBINANT ERYTHROPOIETIN; SIALOPROTEIN;

ANION EXCHANGE; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BIOREACTOR; CELL GROWTH; CHO CELL; CONTROLLED STUDY; FUCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOELECTRIC POINT; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; PROTEIN GLYCOSYLATION; TWO DIMENSIONAL ELECTROPHORESIS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ERYTHROPOIETIN, RECOMBINANT; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HUMANS; OXYGEN; OXYGEN CONSUMPTION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

CRICETULUS GRISEUS; INSECTA;

EID: 33745186462     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.20875     Document Type: Article

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