메뉴 건너뛰기




Volumn 2, Issue 3, 2012, Pages 67-72

COX-2 as a molecular target of colon cancer chemoprevention: Promise and reality

Author keywords

Chemoprevention; Colon cancer; COX 2; Coxibs; NSAIDs

Indexed keywords

ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450; ICOSANOID; LIPOXYGENASE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPASE A2; PROSTAGLANDIN; ROFECOXIB; SULINDAC; TRASTUZUMAB;

EID: 84867332640     PISSN: 22105220     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomag.2012.07.007     Document Type: Review
Times cited : (5)

References (76)
  • 1
    • 0023687241 scopus 로고
    • Colorectal cancer risk, chronic illnesses, operations and medications: Case-control results from the Melbourne Colorectal Cancer Study
    • G. Kune, S. Kune, and L. Watson Colorectal cancer risk, chronic illnesses, operations and medications: case-control results from the Melbourne Colorectal Cancer Study Cancer Res 48 1988 4399 4404
    • (1988) Cancer Res , vol.48 , pp. 4399-4404
    • Kune, G.1    Kune, S.2    Watson, L.3
  • 2
    • 0037138743 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic and clinical issues
    • M.J. Thun, S.J. Henley, and C. Patrono Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic and clinical issues J Natl Cancer Inst 94 2002 252 266
    • (2002) J Natl Cancer Inst , vol.94 , pp. 252-266
    • Thun, M.J.1    Henley, S.J.2    Patrono, C.3
  • 4
    • 0037421984 scopus 로고    scopus 로고
    • A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
    • R.S. Sandler, S. Halabi, J.A. Baron, S. Budinger, E. Paskett, and R. Keresztes A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer N Engl J Med 348 2003 883 890
    • (2003) N Engl J Med , vol.348 , pp. 883-890
    • Sandler, R.S.1    Halabi, S.2    Baron, J.A.3    Budinger, S.4    Paskett, E.5    Keresztes, R.6
  • 5
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs
    • J. Vane Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs Nat New Biol 231 1971 232 235
    • (1971) Nat New Biol , vol.231 , pp. 232-235
    • Vane, J.1
  • 6
    • 0023968630 scopus 로고
    • Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
    • D. Dewitt, and W.L. Smith Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence Proc Natl Acad Sci U S A 85 1988 1412 1416
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 1412-1416
    • Dewitt, D.1    Smith, W.L.2
  • 7
    • 0023855416 scopus 로고
    • Isolation and characterization of the complimentary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase)
    • J. Merlie, D. Fagan, J. Mudd, and P. Needleman Isolation and characterization of the complimentary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase) J Biol Chem 263 1988 3550 3553
    • (1988) J Biol Chem , vol.263 , pp. 3550-3553
    • Merlie, J.1    Fagan, D.2    Mudd, J.3    Needleman, P.4
  • 8
    • 0023915232 scopus 로고
    • Primary structure of sheep seminal vesicle prostaglandin endoperoxide synthase deduced from cDNA sequence
    • C. Yokoyama, T. Takai, and T. Tanabe Primary structure of sheep seminal vesicle prostaglandin endoperoxide synthase deduced from cDNA sequence FEBS Lett 231 1988 347 351
    • (1988) FEBS Lett , vol.231 , pp. 347-351
    • Yokoyama, C.1    Takai, T.2    Tanabe, T.3
  • 10
    • 0029911267 scopus 로고    scopus 로고
    • Flexibility of the NSAID binding site in the structure of human cyclo-oxygenase-2
    • C. Luong, A. Miller, J. Barnett, J. Chow, C. Ramesha, and M.F. Browner Flexibility of the NSAID binding site in the structure of human cyclo-oxygenase-2 Nat Struct Biol 11 1996 927 933
    • (1996) Nat Struct Biol , vol.11 , pp. 927-933
    • Luong, C.1    Miller, A.2    Barnett, J.3    Chow, J.4    Ramesha, C.5    Browner, M.F.6
  • 11
    • 0031717446 scopus 로고    scopus 로고
    • Cyclooxygenases as the principle targets for the action of NSAID's
    • T. Smith Cyclooxygenases as the principle targets for the action of NSAID's Rheum Dis Clin North Am 24 1998 501 523
    • (1998) Rheum Dis Clin North Am , vol.24 , pp. 501-523
    • Smith, T.1
  • 12
    • 0025857560 scopus 로고
    • Prostaglandin endoperoxide synthase: Regulation of enzyme expression
    • D. Dewitt Prostaglandin endoperoxide synthase: regulation of enzyme expression Biochim Biophys Acta 1083 1991 121 134
    • (1991) Biochim Biophys Acta , vol.1083 , pp. 121-134
    • Dewitt, D.1
  • 13
    • 0027146692 scopus 로고
    • Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
    • J. Mitchell, P. Akarasereenont, C. Thiemermann, R.J. Flower, and J.R. Vane Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase Proc Natl Acad Sci U S A 90 1993 11693 11697
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11693-11697
    • Mitchell, J.1    Akarasereenont, P.2    Thiemermann, C.3    Flower, R.J.4    Vane, J.R.5
  • 16
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isoenzymes by aspirin and other non-steroidal anti-inflammatory drugs
    • E. Meade, W. Smith, and D. deWitt Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isoenzymes by aspirin and other non-steroidal anti-inflammatory drugs J Biol Chem 268 1993 6610 6614
    • (1993) J Biol Chem , vol.268 , pp. 6610-6614
    • Meade, E.1    Smith, W.2    Dewitt, D.3
  • 17
    • 0029975669 scopus 로고    scopus 로고
    • Prostaglandin endoperoxide H synthases-1 and -2
    • W. Smith, and D. Dewitt Prostaglandin endoperoxide H synthases-1 and -2 Adv Immunol 62 1996 167 215
    • (1996) Adv Immunol , vol.62 , pp. 167-215
    • Smith, W.1    Dewitt, D.2
  • 18
    • 0032916736 scopus 로고    scopus 로고
    • COX-2 selective inhibitors: The new super aspirins
    • D. DeWitt COX-2 selective inhibitors: the new super aspirins Mol Pharmacol 55 1999 625 631
    • (1999) Mol Pharmacol , vol.55 , pp. 625-631
    • Dewitt, D.1
  • 19
    • 0030017042 scopus 로고    scopus 로고
    • Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts
    • S. Kargman, S. Charleson, M. Cartwright, J. Frank, D. Riendeau, and J. Mancini Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts Gastroenterology 111 1996 445 454
    • (1996) Gastroenterology , vol.111 , pp. 445-454
    • Kargman, S.1    Charleson, S.2    Cartwright, M.3    Frank, J.4    Riendeau, D.5    Mancini, J.6
  • 20
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • C. Eberhart, R. Coffey, A. Radhika, F.M. Giardiello, S. Ferrenbach, and R.N. DuBois Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas Gastroenterology 107 1994 1183 1188
    • (1994) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhart, C.1    Coffey, R.2    Radhika, A.3    Giardiello, F.M.4    Ferrenbach, S.5    Dubois, R.N.6
  • 21
    • 0033601773 scopus 로고    scopus 로고
    • Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer: A population-based study
    • W. Smalley, W. Ray, J. Daugherty, and M.R. Griffin Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer: a population-based study Arch Intern Med 159 1999 161 166
    • (1999) Arch Intern Med , vol.159 , pp. 161-166
    • Smalley, W.1    Ray, W.2    Daugherty, J.3    Griffin, M.R.4
  • 22
    • 0027197062 scopus 로고
    • Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis
    • F. Giardiello, S. Hamilton, A. Krush, S. Piantadosi, L.M. Hylind, and P. Celano Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis N Engl J Med 328 1993 1313 1316
    • (1993) N Engl J Med , vol.328 , pp. 1313-1316
    • Giardiello, F.1    Hamilton, S.2    Krush, A.3    Piantadosi, S.4    Hylind, L.M.5    Celano, P.6
  • 23
    • 0030947525 scopus 로고    scopus 로고
    • Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2
    • H. Sheng, J. Shao, S. Kirkland, P. Isakson, R.J. Coffey, and J. Morrow Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2 J Clin Invest 99 1997 2254 2259
    • (1997) J Clin Invest , vol.99 , pp. 2254-2259
    • Sheng, H.1    Shao, J.2    Kirkland, S.3    Isakson, P.4    Coffey, R.J.5    Morrow, J.6
  • 24
    • 0032006784 scopus 로고    scopus 로고
    • Chemoprotective activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
    • T. Kawamori, C. Rao, K. Seibert, and B. Reddy Chemoprotective activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis Cancer Res 58 1998 409 412
    • (1998) Cancer Res , vol.58 , pp. 409-412
    • Kawamori, T.1    Rao, C.2    Seibert, K.3    Reddy, B.4
  • 25
    • 0030606299 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Apc delta 716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    • M. Oshima, J. Dinchuk, S. Kargman, H. Oshima, B. Hancock, and E. Kwong Suppression of intestinal polyposis in Apc delta 716 knockout mice by inhibition of cyclooxygenase 2 (COX-2) Cell 87 1996 803 809
    • (1996) Cell , vol.87 , pp. 803-809
    • Oshima, M.1    Dinchuk, J.2    Kargman, S.3    Oshima, H.4    Hancock, B.5    Kwong, E.6
  • 26
    • 17744418769 scopus 로고    scopus 로고
    • The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    • G. Steinbach, P. Lynch, R.K. Phillips, M.H. Wallace, E. Hawk, and G.B. Gordon The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis N Engl J Med 342 2000 1946 1952
    • (2000) N Engl J Med , vol.342 , pp. 1946-1952
    • Steinbach, G.1    Lynch, P.2    Phillips, R.K.3    Wallace, M.H.4    Hawk, E.5    Gordon, G.B.6
  • 27
    • 4143086009 scopus 로고    scopus 로고
    • Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid
    • A. Nobuoka, T. Takayama, K. Miyanishi, T. Sato, K. Takanashi, and T. Hayashi Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid Gastroenterology 127 2004 428 443
    • (2004) Gastroenterology , vol.127 , pp. 428-443
    • Nobuoka, A.1    Takayama, T.2    Miyanishi, K.3    Sato, T.4    Takanashi, K.5    Hayashi, T.6
  • 28
    • 0034282465 scopus 로고    scopus 로고
    • Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    • P.C. Chulada, M.B. Thompson, J.F. Mahler, C.M. Doyle, B.W. Gaul, and C. Lee Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice Cancer Res 60 2000 4705 4708
    • (2000) Cancer Res , vol.60 , pp. 4705-4708
    • Chulada, P.C.1    Thompson, M.B.2    Mahler, J.F.3    Doyle, C.M.4    Gaul, B.W.5    Lee, C.6
  • 29
    • 77952674407 scopus 로고    scopus 로고
    • Association of PI3-kinase and Wnt signaling in non-steroidal anti-inflammatory drug-induced apoptosis in experimental colon cancer
    • J. Kaur, and S.N. Sanyal Association of PI3-kinase and Wnt signaling in non-steroidal anti-inflammatory drug-induced apoptosis in experimental colon cancer Am J Biomed Sci 1 2009 395 405
    • (2009) Am J Biomed Sci , vol.1 , pp. 395-405
    • Kaur, J.1    Sanyal, S.N.2
  • 30
    • 77952157424 scopus 로고    scopus 로고
    • Induction of apoptosis as potential chemopreventive effect of dual cyclooxygenase inhibitor, diclofenac in early colon carcinogenesis
    • J. Kaur, and S.N. Sanyal Induction of apoptosis as potential chemopreventive effect of dual cyclooxygenase inhibitor, diclofenac in early colon carcinogenesis J Environ Pathol Toxicol Oncol 29 2010 41 53
    • (2010) J Environ Pathol Toxicol Oncol , vol.29 , pp. 41-53
    • Kaur, J.1    Sanyal, S.N.2
  • 31
    • 77956627421 scopus 로고    scopus 로고
    • Chemoprevention of 1,2-dimethylhydrazine-induced colon carcinogenesis by a non-steroidal anti-inflammatory drug, etoricoxib, in rats: Inhibition of nuclear factor kappaB
    • L. Tanwar, V. Vaish, and S.N. Sanyal Chemoprevention of 1,2-dimethylhydrazine-induced colon carcinogenesis by a non-steroidal anti-inflammatory drug, etoricoxib, in rats: inhibition of nuclear factor kappaB Asian Pac J Cancer Prev 10 2009 1141 1146
    • (2009) Asian Pac J Cancer Prev , vol.10 , pp. 1141-1146
    • Tanwar, L.1    Vaish, V.2    Sanyal, S.N.3
  • 32
    • 77955669840 scopus 로고    scopus 로고
    • Chemopreventive role of etoricoxib (MK-0663) in experimental colon cancer: Induction of mitochondrial proapoptotic factors
    • L. Tanwar, V. Vaish, and S.N. Sanyal Chemopreventive role of etoricoxib (MK-0663) in experimental colon cancer: induction of mitochondrial proapoptotic factors Eur J Cancer Prev 19 2010 280 287
    • (2010) Eur J Cancer Prev , vol.19 , pp. 280-287
    • Tanwar, L.1    Vaish, V.2    Sanyal, S.N.3
  • 33
    • 78049513349 scopus 로고    scopus 로고
    • The role of NF-κB and PPARγ in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors
    • V. Vaish, L. Tanwar, and S.N. Sanyal The role of NF-κB and PPARγ in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors Tumour Biol 31 2010 427 436
    • (2010) Tumour Biol , vol.31 , pp. 427-436
    • Vaish, V.1    Tanwar, L.2    Sanyal, S.N.3
  • 34
    • 81955165475 scopus 로고    scopus 로고
    • Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: An apoptosome study
    • V. Vaish, L. Tanwar, J. Kaur, and S.N. Sanyal Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study J Gastrointest Cancer 42 2011 195 203
    • (2011) J Gastrointest Cancer , vol.42 , pp. 195-203
    • Vaish, V.1    Tanwar, L.2    Kaur, J.3    Sanyal, S.N.4
  • 35
    • 84857188001 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs modulate the physicochemical properties of plasma membrane in experimental colorectal cancer: A fluorescence spectroscopic study
    • V. Vaish, and S.N. Sanyal Non-steroidal anti-inflammatory drugs modulate the physicochemical properties of plasma membrane in experimental colorectal cancer: a fluorescence spectroscopic study Mol Cell Biochem 358 2011 161 171
    • (2011) Mol Cell Biochem , vol.358 , pp. 161-171
    • Vaish, V.1    Sanyal, S.N.2
  • 36
    • 80052695253 scopus 로고    scopus 로고
    • Altered membrane lipid dynamics and chemoprevention by non-steroidal anti inflammatory drugs during colon carcinogenesis
    • S. Singh Kanwar, V. Vaish, and S. Nath Sanyal Altered membrane lipid dynamics and chemoprevention by non-steroidal anti inflammatory drugs during colon carcinogenesis Nutr Hosp 26 2011 1141 1154
    • (2011) Nutr Hosp , vol.26 , pp. 1141-1154
    • Singh Kanwar, S.1    Vaish, V.2    Nath Sanyal, S.3
  • 37
    • 83155192325 scopus 로고    scopus 로고
    • Chemopreventive effects of NSAIDs on cytokines and transcription factors during the early stages of colorectal cancer
    • V. Vaish, and S.N. Sanyal Chemopreventive effects of NSAIDs on cytokines and transcription factors during the early stages of colorectal cancer Pharmacol Rep 63 2011 1210 1221
    • (2011) Pharmacol Rep , vol.63 , pp. 1210-1221
    • Vaish, V.1    Sanyal, S.N.2
  • 38
    • 84858277099 scopus 로고    scopus 로고
    • Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: Exploring NHE-1, intracellular calcium homeostasis and Calpain 9
    • V. Vaish, and S.N. Sanyal Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: Exploring NHE-1, intracellular calcium homeostasis and Calpain 9 Biomed Pharmacother 66 2012 116 130
    • (2012) Biomed Pharmacother , vol.66 , pp. 116-130
    • Vaish, V.1    Sanyal, S.N.2
  • 39
    • 84864017702 scopus 로고    scopus 로고
    • Role of Sulindac and Celecoxib in the regulation of angiogenesis during the early neoplasm of colon: Exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/β-catenin signaling
    • V. Vaish, and S.N. Sanyal Role of Sulindac and Celecoxib in the regulation of angiogenesis during the early neoplasm of colon: exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/β-catenin signaling Biomed Pharmacother 66 2012 354 367
    • (2012) Biomed Pharmacother , vol.66 , pp. 354-367
    • Vaish, V.1    Sanyal, S.N.2
  • 40
    • 84866980922 scopus 로고    scopus 로고
    • Dolastatin 15, a mollusk linear peptide and Celecoxib, a selective cyclooxygenase-2 inhibitor prevent preneoplastic colonic lesions and induce apoptosis via inhibition of the regulatory transcription factor, NF-κB and an inflammatory protein, iNOS
    • 10.1097/CEJ.0b013e328351c69d
    • H. Piplani, V. Vaish, and S.N. Sanyal Dolastatin 15, a mollusk linear peptide and Celecoxib, a selective cyclooxygenase-2 inhibitor prevent preneoplastic colonic lesions and induce apoptosis via inhibition of the regulatory transcription factor, NF-κB and an inflammatory protein, iNOS Eur J Cancer Prev 2012 10.1097/CEJ.0b013e328351c69d
    • (2012) Eur J Cancer Prev
    • Piplani, H.1    Vaish, V.2    Sanyal, S.N.3
  • 42
    • 3042621502 scopus 로고    scopus 로고
    • Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments
    • C.T. Dang, A.J. Dannenberg, K. Subbaramaiah, M.N. Dickler, and M.M. Moasser Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments Clin Cancer Res 10 2004 4062 4067
    • (2004) Clin Cancer Res , vol.10 , pp. 4062-4067
    • Dang, C.T.1    Dannenberg, A.J.2    Subbaramaiah, K.3    Dickler, M.N.4    Moasser, M.M.5
  • 43
    • 0142250380 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients
    • T. Higuchi, T. Iwama, K. Yoshinaga, M. Toyooka, M.M. Taketo, and K. Sugihara A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients Clin Cancer Res 9 2003 4756 4760
    • (2003) Clin Cancer Res , vol.9 , pp. 4756-4760
    • Higuchi, T.1    Iwama, T.2    Yoshinaga, K.3    Toyooka, M.4    Taketo, M.M.5    Sugihara, K.6
  • 44
    • 0038795405 scopus 로고    scopus 로고
    • Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: A phase II study
    • C.R. Becerra, E.P. Frenkel, R. Ashfaq, and R.B. Gaynor Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: a phase II study Int J Cancer 105 2003 868 872
    • (2003) Int J Cancer , vol.105 , pp. 868-872
    • Becerra, C.R.1    Frenkel, E.P.2    Ashfaq, R.3    Gaynor, R.B.4
  • 45
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in human neoplasia: Rationale and promise
    • A.J. Dannenberg, and K. Subbaramaiah Targeting cyclooxygenase-2 in human neoplasia: rationale and promise Cancer Cell 4 2003 431 436
    • (2003) Cancer Cell , vol.4 , pp. 431-436
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 46
    • 0033594911 scopus 로고    scopus 로고
    • Nonsteroidal drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
    • T.D. Warner, F. Giuliano, I. Vojnovic, A. Bukasa, J.A. Mitchell, and J.R. Vane Nonsteroidal drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis Proc Natl Acad Sci U S A 96 1999 7563 7568
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7563-7568
    • Warner, T.D.1    Giuliano, F.2    Vojnovic, I.3    Bukasa, A.4    Mitchell, J.A.5    Vane, J.R.6
  • 48
    • 0028850446 scopus 로고
    • Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment. Advantages of a low-dose nonsteroidal anti-inflammatory drug regimen in reversing adenomas exceeding 33 months
    • G. Winde, K.W. Schmid, W. Schlegel, R. Fischer, H. Osswald, and H. Bunte Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment. Advantages of a low-dose nonsteroidal anti-inflammatory drug regimen in reversing adenomas exceeding 33 months Dis Colon Rectum 38 1995 813 830
    • (1995) Dis Colon Rectum , vol.38 , pp. 813-830
    • Winde, G.1    Schmid, K.W.2    Schlegel, W.3    Fischer, R.4    Osswald, H.5    Bunte, H.6
  • 49
    • 0034644396 scopus 로고    scopus 로고
    • Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Longterm Arthritis Safety Study
    • F.E. Silverstein, G. Faich, J.L. Goldstein, L.S. Simon, T. Pincus, and A. Whelton Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Longterm Arthritis Safety Study J Am Med Assoc 284 2000 1247 1255
    • (2000) J Am Med Assoc , vol.284 , pp. 1247-1255
    • Silverstein, F.E.1    Faich, G.2    Goldstein, J.L.3    Simon, L.S.4    Pincus, T.5    Whelton, A.6
  • 50
    • 6044274282 scopus 로고    scopus 로고
    • Coxibs and cardiovascular disease
    • G.A. Fitzgerald Coxibs and cardiovascular disease N Engl J Med 351 2004 1709 1711
    • (2004) N Engl J Med , vol.351 , pp. 1709-1711
    • Fitzgerald, G.A.1
  • 51
    • 4143107932 scopus 로고    scopus 로고
    • Cyclooxygenase isozymes: The biology of prostaglandin synthesis and inhibition
    • D.L. Simmons, R.M. Botting, and T. Hla Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition Pharmacol Rev 56 2004 387 437
    • (2004) Pharmacol Rev , vol.56 , pp. 387-437
    • Simmons, D.L.1    Botting, R.M.2    Hla, T.3
  • 52
    • 0029790770 scopus 로고    scopus 로고
    • Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress
    • J.N. Topper, J. Cai, D. Falb, and M.A. Gimbrone Jr. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress Proc Natl Acad Sci U S A 93 1996 10417 10422
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 10417-10422
    • Topper, J.N.1    Cai, J.2    Falb, D.3    Gimbrone, Jr.M.A.4
  • 53
    • 0033524421 scopus 로고    scopus 로고
    • Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2
    • B.F. McAdam, F. Catella-Lawson, I.A. Mardini, S. Kapoor, J.A. Lawson, and G.A. Fitzgerald Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2 Proc Natl Acad Sci U S A 96 1999 272 277
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 272-277
    • McAdam, B.F.1    Catella-Lawson, F.2    Mardini, I.A.3    Kapoor, S.4    Lawson, J.A.5    Fitzgerald, G.A.6
  • 54
    • 0036468255 scopus 로고    scopus 로고
    • Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer
    • R.L. Keith, Y.E. Miller, Y. Hoshikawa, M.D. Moore, T.L. Gesell, and B. Gao Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer Cancer Res 62 2002 734 740
    • (2002) Cancer Res , vol.62 , pp. 734-740
    • Keith, R.L.1    Miller, Y.E.2    Hoshikawa, Y.3    Moore, M.D.4    Gesell, T.L.5    Gao, B.6
  • 55
    • 4143070427 scopus 로고    scopus 로고
    • Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice
    • R.L. Keith, Y.E. Miller, T.M. Hudish, C.E. Girod, S. Sotto-Santiago, and W.A. Franklin Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice Cancer Res 64 2004 5897 5904
    • (2004) Cancer Res , vol.64 , pp. 5897-5904
    • Keith, R.L.1    Miller, Y.E.2    Hudish, T.M.3    Girod, C.E.4    Sotto-Santiago, S.5    Franklin, W.A.6
  • 56
    • 0035417925 scopus 로고    scopus 로고
    • Lipoxygenase modulation to reverse carcinogenesis
    • I. Shureiqi, and S.M. Lippman Lipoxygenase modulation to reverse carcinogenesis Cancer Res 61 2001 6307 6312
    • (2001) Cancer Res , vol.61 , pp. 6307-6312
    • Shureiqi, I.1    Lippman, S.M.2
  • 57
    • 6044256286 scopus 로고    scopus 로고
    • Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide
    • J.T. Mao, I.H. Tsu, S.M. Dubinett, B. Adams, T. Sarafian, and F. Baratelli Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide Clin Cancer Res 10 2004 6872 6878
    • (2004) Clin Cancer Res , vol.10 , pp. 6872-6878
    • Mao, J.T.1    Tsu, I.H.2    Dubinett, S.M.3    Adams, B.4    Sarafian, T.5    Baratelli, F.6
  • 58
    • 0030602860 scopus 로고    scopus 로고
    • Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway
    • R. Hanif, A. Pittas, Y. Feng, M.I. Koutsos, L. Qiao, and L. Staiano-Coico Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway Biochem Pharmacol 52 1996 237 245
    • (1996) Biochem Pharmacol , vol.52 , pp. 237-245
    • Hanif, R.1    Pittas, A.2    Feng, Y.3    Koutsos, M.I.4    Qiao, L.5    Staiano-Coico, L.6
  • 59
    • 0033575796 scopus 로고    scopus 로고
    • The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs)
    • S.J. Shiff, and B. Rigas The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs) J Exp Med 190 1999 445 450
    • (1999) J Exp Med , vol.190 , pp. 445-450
    • Shiff, S.J.1    Rigas, B.2
  • 60
    • 0345275877 scopus 로고    scopus 로고
    • Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB and NO synthase 2 inhibition: Implications for chemoprevention
    • J.L. Williams, N. Nath, J. Chen, T.R. Hundley, J. Gao, and L. Kopelovich Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB and NO synthase 2 inhibition: implications for chemoprevention Cancer Res 63 2003 7613 7618
    • (2003) Cancer Res , vol.63 , pp. 7613-7618
    • Williams, J.L.1    Nath, N.2    Chen, J.3    Hundley, T.R.4    Gao, J.5    Kopelovich, L.6
  • 61
    • 0035951493 scopus 로고    scopus 로고
    • Cancer research. Anti-inflammatories inhibit cancer growth-but how?
    • J. Marx Cancer research. Anti-inflammatories inhibit cancer growth-but how? Science 291 2001 581 582
    • (2001) Science , vol.291 , pp. 581-582
    • Marx, J.1
  • 62
    • 0029115954 scopus 로고
    • Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence and induces apoptosis in HT-29 colon adenocarcinoma cells
    • S.J. Shiff, L. Qiao, L.L. Tsai, and B. Rigas Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence and induces apoptosis in HT-29 colon adenocarcinoma cells J Clin Invest 96 1995 491 503
    • (1995) J Clin Invest , vol.96 , pp. 491-503
    • Shiff, S.J.1    Qiao, L.2    Tsai, L.L.3    Rigas, B.4
  • 63
    • 0035650943 scopus 로고    scopus 로고
    • COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib
    • S. Grosch, I. Tegeder, E. Niederberger, L. Brautigam, and G. Geisslinger COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib FASEB J 15 2001 2742 2744
    • (2001) FASEB J , vol.15 , pp. 2742-2744
    • Grosch, S.1    Tegeder, I.2    Niederberger, E.3    Brautigam, L.4    Geisslinger, G.5
  • 64
    • 77954749264 scopus 로고    scopus 로고
    • Intrinsic mitochondrial membrane potential change and associated events mediate apoptosis in chemopreventive effect of diclofenac in colon cancer
    • J. Kaur, and S.N. Sanyal Intrinsic mitochondrial membrane potential change and associated events mediate apoptosis in chemopreventive effect of diclofenac in colon cancer Oncol Res 18 2010 481 492
    • (2010) Oncol Res , vol.18 , pp. 481-492
    • Kaur, J.1    Sanyal, S.N.2
  • 65
    • 78449241791 scopus 로고    scopus 로고
    • PI3-kinase/Wnt signaling association mediates COX-2/PGE2 pathway to inhibit apoptosis in early stages of colon carcinogenesis and its chemoprevention by diclofenac
    • J. Kaur, and S.N. Sanyal PI3-kinase/Wnt signaling association mediates COX-2/PGE2 pathway to inhibit apoptosis in early stages of colon carcinogenesis and its chemoprevention by diclofenac Tumor Biol 31 2010 623 631
    • (2010) Tumor Biol , vol.31 , pp. 623-631
    • Kaur, J.1    Sanyal, S.N.2
  • 66
    • 77955013537 scopus 로고    scopus 로고
    • Oxidative stress and stress-signaling in chemoprevention of early colon cancer by diclofenac
    • J. Kaur, and S.N. Sanyal Oxidative stress and stress-signaling in chemoprevention of early colon cancer by diclofenac Am J Biomed Sci 2 2010 63 78
    • (2010) Am J Biomed Sci , vol.2 , pp. 63-78
    • Kaur, J.1    Sanyal, S.N.2
  • 67
    • 77955270210 scopus 로고    scopus 로고
    • Modulation of inflammatory changes in early stages of colon cancer through activation of PPARγ by diclofenac
    • J. Kaur, and S.N. Sanyal Modulation of inflammatory changes in early stages of colon cancer through activation of PPARγ by diclofenac Eur J Cancer Prev 19 2010 319 327
    • (2010) Eur J Cancer Prev , vol.19 , pp. 319-327
    • Kaur, J.1    Sanyal, S.N.2
  • 68
    • 0842347429 scopus 로고    scopus 로고
    • Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma
    • A.F. Badawi, M.B. Eldeen, Y. Liu, E.A. Ross, and M.Z. Badr Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma Cancer Res 64 2004 1181 1189
    • (2004) Cancer Res , vol.64 , pp. 1181-1189
    • Badawi, A.F.1    Eldeen, M.B.2    Liu, Y.3    Ross, E.A.4    Badr, M.Z.5
  • 69
    • 11944270441 scopus 로고    scopus 로고
    • Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9
    • H. Ding, C. Han, J. Zhu, C.S. Chen, and S.M. D'Ambrosio Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9 Int J Cancer 113 2005 803 810
    • (2005) Int J Cancer , vol.113 , pp. 803-810
    • Ding, H.1    Han, C.2    Zhu, J.3    Chen, C.S.4    D'Ambrosio, S.M.5
  • 70
    • 1642407595 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
    • T.J. Maier, K. Schilling, R. Schmidt, G. Geisslinger, and S. Grosch Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells Biochem Pharmacol 67 2004 1469 1478
    • (2004) Biochem Pharmacol , vol.67 , pp. 1469-1478
    • Maier, T.J.1    Schilling, K.2    Schmidt, R.3    Geisslinger, G.4    Grosch, S.5
  • 72
    • 0036829336 scopus 로고    scopus 로고
    • Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells
    • Y. Sun, X.M. Tang, E. Half, M.T. Kuo, and F.A. Sinicrope Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells Cancer Res 62 2002 6323 6328
    • (2002) Cancer Res , vol.62 , pp. 6323-6328
    • Sun, Y.1    Tang, X.M.2    Half, E.3    Kuo, M.T.4    Sinicrope, F.A.5
  • 73
    • 1642540579 scopus 로고    scopus 로고
    • Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition
    • A. Weber, A. Casini, A. Heine, D. Kuhn, C.T. Supuran, and A. Scozzafava Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition J Med Chem 47 2004 550 557
    • (2004) J Med Chem , vol.47 , pp. 550-557
    • Weber, A.1    Casini, A.2    Heine, A.3    Kuhn, D.4    Supuran, C.T.5    Scozzafava, A.6
  • 74
    • 9644281593 scopus 로고    scopus 로고
    • Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway
    • K. Yamaguchi, S.H. Lee, T.E. Eling, and S.J. Baek Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway J Biol Chem 279 2004 49617 49623
    • (2004) J Biol Chem , vol.279 , pp. 49617-49623
    • Yamaguchi, K.1    Lee, S.H.2    Eling, T.E.3    Baek, S.J.4
  • 75
    • 0036531924 scopus 로고    scopus 로고
    • Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines
    • C. Waskewich, R.D. Blumenthal, H. Li, R. Stein, D.M. Goldenberg, and J. Burton Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines Cancer Res 62 2002 2029 2033
    • (2002) Cancer Res , vol.62 , pp. 2029-2033
    • Waskewich, C.1    Blumenthal, R.D.2    Li, H.3    Stein, R.4    Goldenberg, D.M.5    Burton, J.6
  • 76
    • 13444260752 scopus 로고    scopus 로고
    • Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor
    • G. Eibl, Y. Takata, L.G. Boros, J. Liu, Y. Okada, and H.A. Reber Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor Cancer Res 65 2005 982 990
    • (2005) Cancer Res , vol.65 , pp. 982-990
    • Eibl, G.1    Takata, Y.2    Boros, L.G.3    Liu, J.4    Okada, Y.5    Reber, H.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.