Effect of grapefruit juice and ritonavir on pharmacokinetics of lopinavir in wistar rats

Phytotherapy Research

Volumn 26, Issue 10, 2012, Pages 1490-1495

  Ravi, P R ^a   Vats, R ^a   Thakur, R ^a   Srivani, S ^a   Aditya, N ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

drug interaction; grapefruit juice; lopinavir; pharmacokinetics; ritonavir

Indexed keywords

CYTOCHROME P450 3A; LOPINAVIR; MULTIDRUG RESISTANCE PROTEIN; RITONAVIR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APPARENT PERMEABILITY; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENTIATION; DRUG TRANSPORT; ENZYME INHIBITION; EX VIVO STUDY; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; ILEUM; IN VIVO STUDY; INTESTINAL MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MICROSOME; NONHUMAN; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BEVERAGES; CITRUS PARADISI; DRUG SYNERGISM; FOOD-DRUG INTERACTIONS; HIV PROTEASE INHIBITORS; INTESTINAL ABSORPTION; INTESTINES; LOPINAVIR; MALE; MICROSOMES; RATS; RATS, WISTAR; RITONAVIR;

CITRUS X PARADISI; RATTUS; RATTUS NORVEGICUS;

EID: 84867332395     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4593     Document Type: Article

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