Ginsenoside Rg1 attenuates tau phosphorylation in SK-N-SH induced by Aβ-stimulated THP-1 supernatant and the involvement of p38 pathway activation

Life Sciences

Volumn 91, Issue 15-16, 2012, Pages 809-815

  Li, Wei ^a   Chu, Yanqi ^b   Zhang, Lan ^b   Yin, Linlin ^b   Li, Lin ^b  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Amyloid 1 40; Ginsenoside Rg1; p38 MAPK; SK N SH neuroblastoma; Tau phosphorylation; THP 1 monocytes

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; GINSENOSIDE RG 1; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; SYNAPTOPHYSIN; TAU PROTEIN;

ARTICLE; ATTENUATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INCUBATION TIME; INTRACELLULAR SIGNALING; MONOCYTE; NERVE CELL LESION; NERVE DEGENERATION; NEUROBLASTOMA; NEUROBLASTOMA CELL; NEUROTOXICITY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; SUPERNATANT; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION; GINSENOSIDES; HUMANS; INTERLEUKIN-1BETA; MICROTUBULE-ASSOCIATED PROTEINS; MONOCYTES; NEUROBLASTOMA; NEURONS; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNAPTOPHYSIN; TAU PROTEINS;

EID: 84867329423     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.08.028     Document Type: Article

References (40)

1. S.W. Barger, and A.S. Basile Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function J Neurochem 76 2001 846 854
2. J. Bertrand, V. Plouffe, P. Sénéchal, and N. Leclerc The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons Neuroscience 168 2010 323 334
3. B.K. Binukumar, A. Bal, and K.D. Gill Chronic dichlorvos exposure: microglial activation, proinflammatory cytokines and damage to nigrostriatal dopaminergic system Neuromolecular Med 13 2011 251 265
4. J. Busciglio, A. Lorenzo, J. Yeh, and B.A. Yankner Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding Neuron 14 1995 879 888
5. L.M. Callahan, and P.D. Coleman Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease Neurobiol Aging 16 1995 311 314
6. Y. Cheng, L.H. Shen, and J.T. Zhang Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action Acta Pharmacol Sin 26 2005 143 149
7. G. Esposito, D. De Filippis, R. Carnuccio, A.A. Izzo, and T. Iuvone The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells J Mol Med (Berl) 84 2006 253 258
8. R.K. Giri, S.K. Selvaraj, and V.K. Kalra Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA J Immunol 170 2003 5281 5294
9. M.A. Hebert, L.I. Serova, and E.L. Sabban Single and repeated immobilization stress differentially trigger induction and phosphorylation of several transcription factors and mitogen-activated protein kinases in the rat locus coeruleus J Neurochem 95 2005 484 498
10. M.J. Hsu, C.Y. Hsu, B.C. Chen, M.C. Chen, G. Ou, and C.H. Lin Apoptosis signal-regulating kinase 1 in amyloid beta peptide-induced cerebral endothelial cell apoptosis J Neurosci 27 2007 5719 5729
11. A. Klegeris, D.G. Walker, and P.L. McGeer Toxicity of human THP-1 monocytic cells toward neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs) Neuropharmacology 38 1999 1017 1025
12. V.M. Lee, M. Goedert, and J.Q. Trojanowski Neurodegenerative tauopathies Annu Rev Neurosci 24 2001 1121 1159
13. V. Leinonen, A.M. Koivisto, S. Savolainen, J. Rummukainen, J.N. Tamminen, and T. Tillgren Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease Ann Neurol 68 2010 446 453
14. Y. Li, L. Liu, S.W. Barger, and W.S. Griffin Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway J Neurosci 23 2003 1605 1611
15. X. Li, Y. Liu, H.F. Yuan, and Q.K. Quan Effects of gensenoside Rg1 on tau protein phosphorylation induced by okadaic acid in rat brain slices Zhong Xi Yi Jie He Xue Bao 8 2010 955 960
16. X. Li, Y. Liu, X. Zhang, H. Yuan, and Q. Quan Effect of ginsenoside Rg1 on expressions of phosphory protein tau and N-methyl-d-aspartate receptor subunits NR1 and NR2B in rat brain slice model of Alzheimer's disease Zhongguo Zhong Yao Za Zhi 35 2010 3339 3343
17. Q. Lu, T.F. Rau, V. Harris, M. Johnson, D.J. Poulsen, and S.M. Black Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures Eur J Neurosci 34 2011 1093 1101
18. Z.C. Ma, Y. Gao, J. Wang, X.M. Zhang, and S.Q. Wang Proteomic analysis effects of ginsenoside Rg1 on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha Life Sci 79 2006 175 181
19. B. Mackic, M.H. Weiss, W. Miao, E. Kirkman, J. Ghiso, and M. Calero Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid β peptide in aged squirrel monkey with cerebral amyloid angiopathy J Neurochem 70 1998 210 215
20. E. Masliah, M. Mallory, M. Alford, R. DeTeresa, L.A. Hansen, and D.W. McKeel Jr. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease Neurology 56 2001 127 129
21. M.P. Mattson Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives Physiol Rev 77 1997 1081 1132
22. G. Meng, Y. Sun, W. Fu, Z. Guo, and L. Xu Microcystin-LR induces cytoskeleton system reorganization through hyperphosphorylation of tau and HSP27 via PP2A inhibition and subsequent activation of the p38 MAPK signaling pathway in neuroendocrine (PC12) cells Toxicology 290 2011 219 230
23. I. Mook-Jung, H.S. Hong, J.H. Boo, K.H. Lee, S.H. Yun, and M.Y. Cheong Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice J Neurosci Res 63 2001 509 515
24. B.M. Nie, X.Y. Jiang, J.X. Cai, S.L. Fu, L.M. Yang, and L. Lin Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity Neuropharmacology 54 2008 845 853
25. H. Quigley, S.J. Colloby, and J.T. O'Brien PET imaging of brain amyloid in dementia: a review Int J Geriatr Psychiatry 26 2011 991 999
26. K. Radad, G. Gille, L. Liu, and W.D. Rausch Use of ginseng in medicine with emphasis on neurodegenerative disorders J Pharmacol Sci 100 2006 175 186
27. C.H. Reynolds, J.C. Betts, W.P. Blackstock, A.R. Nebreda, and B.H. Anderton Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta J Neurochem 74 2000 1587 1595
28. M. Rudakewich, F. Ba, and C.G. Benishin Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1) Planta Med 67 2001 533 537
29. 1-40/vector complex Proc Natl Acad Sci U S A 92 1995 10227 10231
30. A. Serrano-Pozo, M.L. Mielke, T. Gómez-Isla, R.A. Betensky, J.H. Growdon, and M.P. Frosch Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease Am J Pathol 179 2011 1373 1384
31. L.H. Shen, and J.T. Zhang Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells Neurol Res 26 2004 422 428
32. J.G. Sheng, R.A. Jones, X.Q. Zhou, J.M. McGinness, L.J. Van Eldik, and R.E. Mrak Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation Neurochem Int 39 2001 341 348
33. Q. Shi, Q. Hao, J. Bouissac, Y. Lu, S. Tian, and B. Luu Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells Life Sci 76 2005 983 995
34. M.S. Song, G. Rauw, G.B. Baker, and S. Kar Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation Eur J Neurosci 28 2008 1989 2002
35. K. Sun, C.S. Wang, J. Guo, Y. Horie, S.P. Fang, and F. Wang Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery Life Sci 81 2007 509 518
36. J.F. Xue, Z.J. Liu, J.F. Hu, H. Chen, J.T. Zhang, and N.H. Chen Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway Brain Res 1106 2006 91 98
37. L.L. Yin, W. Li, Y.Q. Chu, and L. Li ERK pathway activation is required for amyloid-β(1-40)(-)induced neurotoxicity of THP-1 human monocytes towards SK-N-SH neuroblastoma Brain Res 1378 2011 9 17
38. K.W. Zeng, H. Ko, H.O. Yang, and X.M. Wang Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells Neuropharmacology 59 2010 542 550
39. Z. Zhang, R. Zhao, Y. Tang, S. Wen, D. Wang, and J. Qi Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons Neurochem Res 36 2011 801 811
40. X. Zhen, W. Du, A.G. Romano, E. Friedman, and J.A. Harvey The p38 mitogen-activated protein kinase is involved in associative learning in rabbits J Neurosci 21 2001 5513 5519