Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs)

Neuropharmacology

Volumn 38, Issue 7, 1999, Pages 1017-1025

  Klegeris, A ^a   Walker, D G ^a   McGeer, P L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer's disease; Cyclooxygenase; Inflammation; Microglia; Neurotoxicity; NSAIDs; Therapy

Indexed keywords

DICLOFENAC; FLURBIPROFEN; GAMMA INTERFERON; IBUPROFEN; INDOMETACIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; NORDIHYDROGUAIARETIC ACID; PARACETAMOL; PREDNISONE; PROPENTOFYLLINE;

ALZHEIMER DISEASE; ARTICLE; BIOLOGICAL MODEL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; NEUROTOXICITY; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL SURVIVAL; CELLS, CULTURED; HUMANS; MONOCYTES; MONOCYTES, ACTIVATED KILLER; NEURONS;

EID: 0032971129     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00014-3     Document Type: Article

References (52)

1. Barrios-Rodiles M., Keller K., Belley A., Chadee K. Nonsteroidal antiinflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages. Biochem. Biophys. Res. Commun. 225:1996;896-900.
2. Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell. 77:1994;817-827.
3. Bertozzi B., Barbisoni P., Franzoni S., Frisoni G.B., Rozzini R., Trabucchi M. Association of chronic non-steroidal anti-inflammatory drugs use and cognitive decline in non-demented elderly patients admitted to a Geriatric Evaluation and Rehabilitation Unit. Arch. Gerontal. Geriatr. 23:1996;71-79.
4. Braak H., Braak E., Bohl J., Reintjes R. Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's disease. Neurosci. Lett. 210:1996;87-90.
5. Corasaniti M.T., Melino G., Navarra M., Garaci E., Finazzi-Agro A., Nistico G. Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. Neurodegeneration. 4:1995;315-321.
6. Decker T., Lohmann-Matthes M.-L. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J. Immunol. Methods. 15:1988;61-69.
7. Dzenko K.A., Weltzien R.B., Pachter J.S. Suppression of A beta-induced monocyte neurotoxicity by antiinflammatory compounds. J. Neuroimmunol. 80:1997;6-12.
8. Engelhardt G., Bogel R., Schnitzer C., Utzmann R. Meloxicam: influence on arachidonic acid metabolism. Part 1. In vitro findings. Biochem. Pharmacol. 51:1996;21-28.
9. Fabian R.H., Charmaine R. Neuronal toxicity by macrophages in mixed brain cell culture is augmented by antineuronal IgG and dependent upon nitric oxide synthesis. J. Neuroimmunol. 44:1993;95-102.
10. Fagarasan M.O., Efthimiopoulos S. Mechanism of amyloid beta-peptide (1-42) toxicity in PC12 cells. Mol. Psychiatr. 1:1996;398-403.
11. Flavin M.P., Ho L.T., Coughlin K. Neurotoxicity of soluble macrophage products in vitro - influence of dexamethasone. Exp. Neurol. 145:1997;462-470.
12. Frolich J.C. A classification of NSAIDs according to their relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol. Sci. 18:1997;30-34.
13. Giulian D., Vaca K., Noonan C.A. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science. 250:1990;1593-1596.
14. Giulian D., Haverkamp L.J., Li J., Karshin W.L., Yu J., Tom D., Li X., Kirkpatrick J.B. Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochem. Int. 27:1995;119-137.
15. Goppelt-Struebe M., Schaefer D., Habenicht A.J. Differential regulation of cyclo-oxygenase-2 and 5-lipoxygenase-activating protein (FLAP) expression by glucocorticoids in monocytic cells. Br. J. Pharmacol. 122:1997;619-624.
16. Hansen M.B., Nielsen S.E., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods. 119:1989;203-210.
17. Heyes M.P., Achim C.L., Wiley C.A., Major E.O., Saito K., Markey S.P. Human microglia convert L-tryptophan into the neurotoxin quinolinic acid. Biochem. J. 320:1996;595-597.
18. Hsu H.-Y., Nicholson A.C., Hajjar D.P. Inhibition of macrophage scavenger receptor activity by tumor necrosis factor-α is transcriptionally and post-translationally regulated. J. Biol. Chem. 271:1996;7767-7773.
19. Kalaria R.N., Cohen D.L., Premkumar D.R.D. Cellular aspects of the inflammatory response in Alzheimer's disease. Neurodegeneration. 5:1996;497-503.
20. Kataoka M., Tonooka K., Ando T., Imai K., Aimoto T. Hydroxyl radical scavenging activity of nonsteroidal anti-inflammatory drugs. Free Radic. Res. 27:1997;419-427.
21. Klegeris A., McGeer P.L. Inhibition of respiratory burst in macrophages by complement receptor blockade. Eur. J. Pharmacol. 260:1994;273-277.
22. Klegeris A., Walker D.G., McGeer P.L. Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α Brain Res. 747:1997;114-121.
23. Klegeris A., Walker D.G., McGeer P.L. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells. J. Neuroimmunol. 78:1997;152-161.
24. Mackenzie I.R.A., Munoz D.G. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology. 50:1998;986-990.
25. McGeer P.L., McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21:1995;195-218.
26. McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies. Neurology. 47:1996;425-432.
27. McMillian M.K., Vainio P.J., Tuominen R.K. Role of protein kinase C in microglia-induced neurotoxicity in mesencephalic cultures. J. Neuropathol. Exp. Neurol. 56:1997;301-307.
28. Meade E.A., Smith W.L., DeWitt D.L. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:1993;6610-6614.
29. Meda L., Cassatella M.A., Szendrei G.I., Otvos L. Jr, Baron P., Villalba M., Ferrari D., Rossi F. Activation of microglial cells by β-amyloid protein and interferon-γ Nature. 374:1995;647-650.
30. Minghetti L., Polazzi E., Nicolini A., Creminon C., Levi G. Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs. Eur. J. Neurosci. 9:1997;934-940.
31. Mitchell J.A., Akarasereenont P., Thiemermann C., Flower R.J., Vane J.R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA. 90:1994;11693-11697.
32. Mitchell J.A., Larkin S., Williams T.J. Cyclooxygenase-2: regulation and relevance in inflammation. Biochem. Pharmacol. 50:1995;1535-1542.
33. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
34. Nakatsugi S., Sugimoto N., Furukawa M. Effects of non-steroidal anti-inflammatory drugs on prostaglandin E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic acid in rat peritoneal macrophages stimulated with lipopolysaccharide. Prostaglandins Leukot. Essent. Fatty Acids. 55:1996;451-457.
35. Peterson P.K., Hu S., Anderson W.R., Chao C.C. Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J. Infect. Dis. 170:1994;457-460.
36. Piani D., Spranger M., Frei K., Schaffner A., Fontana A. Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines. Eur. J. Immunol. 22:1992;2429-2436.
37. Prieto J., Eklund A., Patarroyo M. Regulated expression of integrins and other adhesion molecules during differentiation of monocytes into macrophages. Cell. Immunol. 156:1994;191-211.
38. Riendeau D., Charleson S., Cromlish W., Mancini J.A., Wong E., Guay J. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can. J. Physiol. Pharmacol. 75:1997;1088-1095.
39. Robinson T.W., Sevanian A., Forman H.J. Inhibition of arachidonic acid release by nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and Chinese hamster fibroblasts. Toxicol. Appl. Pharmacol. 105:1990;113-122.
40. Rogers J., Kirby L.C., Hempelman S.R., Berry D.L., McGeer P.L., Kaszniak A.W., Zalinski J., Cofield M., Mansukhani L., Willson P., Kogan F. Clinical trial of indomethacin in Alzheimer's disease. Neurology. 43:1993;1609-1611.
41. Ross R.A., Biedler J.L., Spengler B.A., Reis D.J. Neurotransmitter-synthesizing enzymes in 14 human neuroblastoma cell lines. Cell. Mol. Neurobiol. 1:1981;301-312.
42. Rozzini R., Ferrucci L., Losonczy K., Havlik R.J., Guralnik J.M. Protective effect of chronic NSAID use on cognitive decline in older persons. J. Am. Geriatr. Soc. 44:1996;1025-1029.
43. Sidell N., Altman A., Haussler M.R., Seeger R.C. Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines. Exp. Cell. Res. 148:1983;21-30.
44. Smith C.J., Morrow J.D., Roberts L.J., Marnett L.J. Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1). Biochem. Biophys. Res. Commun. 192:1993;787-793.
45. Smith W.L., Meade E.A., DeWitt D.L. Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann. NY Acad. Sci. 744:1994;50-55.
46. Soncin F., Calderwood S.K. Reciprocal effects of pro-inflammatory stimuli and anti-inflammatory drugs on the activity of heat shock factor-1 in human monocytes. Biochem. Biophys. Res. Commun. 229:1996;479-484.
47. Stewart W.F., Kawas C., Corrada M., Metter E.J. Risk of Alzheimer's disease and duration of NSAID use. Neurology. 48:1997;626-632.
48. Tanaka M., Sotomatsu A., Yoshida T., Hirai S., Nishida A. Detection of superoxide production by activated microglia using sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death. J. Neurochem. 63:1994;266-270.
49. 2 and a β-adrenergic agonist. Glia. 11:1994;383-386.
50. Tsuchiya S., Kobayashi Y., Goto Y., Okumura H., Nakae S., Konno T., Tada K. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res. 42:1982;1530-1536.
51. Walker D.G., Kim S.U., McGeer P.L. Complement and cytokine gene expression in cultured microglia derived from postmortem human brains. J. Neurosci. Res. 40:1995;478-493.
52. Wisniewski H.M., Wegiel J. Alzheimer's disease neuropathology. Current status of interpretation of lesion development. Ann. NY Acad. Sci. 673:1992;270-284.