Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice

Journal of Neuroscience Research

Volumn 63, Issue 6, 2001, Pages 509-515

  Mook Jung, Inhee ^a   Hong, Hyun Seok ^a   Boo, Jung Hyun ^a   Lee, Kang Hee ^a   Yun, Sung Hwan ^a   Cheong, Mi Young ^a   Joo, Insoo ^a   Huh, Kyoon ^a   Jung, Min Whan ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Cognitive enhancer; Ginseng; Hippocampus; Long term potentiation; Spatial memory; Water maze

Indexed keywords

GINSENOSIDE RB 1; GINSENOSIDE RB 2; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; FACILITATION; HIPPOCAMPUS; LONG TERM POTENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPATIAL ORIENTATION;

ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; COGNITION; ELECTROPHYSIOLOGY; GINSENOSIDES; HIPPOCAMPUS; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; SAPONINS; SPACE PERCEPTION; SYNAPSES; SYNAPTOPHYSIN;

EID: 0035869723     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1045     Document Type: Article

References (59)

1. Differential effects of ginsenoside Rb1 and malonylginsenoside Rb1 on long-term potentiation in the dentate gyrus of rats
2. Spatial learning and memory processes: The search for their neurobiological mechanisms in the rat
3. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings
4. Effects of ginsenoside Rb1 on central cholinergic metabolism
5. Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer's disease
6. Testing the NMDA, long-term potentiation, and cholineric hypotheses of spatial learning
7. Effects of Panax ginseng and its constituents on drug-induced memory impairment in rats
8. Alzheimer's disease: A disorder of cortical cholinergic innervation
9. Two functional components of the hippocampal memory system
10. The modulation of neurotransmitter release at synaptic junctions
11. Hippocampal neurodegeneration in aging
12. Abnormality of neural circuitry in Alzheimer's disease: Hippocampus and cortical cholinergic innervation
13. Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures
14. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
15. Effect of Panax ginseng extract on passive avoidance retention in old rats
16. Korean red ginseng saponins with low ratios of protopanaxdiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice
17. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration
18. Cholinesterase inhibitors: A therapeutic strategy for Alzheimer disease
19. Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation
20. Effect of piracetam and of standardized ginseng extract on the electroconvulsive shock-induced memory disturbances in "step-down" passive avoidance
21. Inhibition of apoptosis by ginsenoside Rg1 in cultured cortical neurons
22. Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root
23. Effect of a polysaccharide fraction of ginseng root on learning and memory in rats (using an active escape response as an example)
24. Why there are complementary learning systems in the hippocampus and neocortex: Insights from the successes and failures of connectionist models of learning and memory
25. The hippocampus and space revisited
26. Age-changes of brain synapses and synaptic plasticity in response to an enriched environment
27. Panax ginseng extract improves scopolamine-induced deficits in working memory performance in the T-maze delayed alternation task in rats
28. Effects of ginseng saponins on cultured neuron cells
29. Malonylginsenoside Rb1 potentiates nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia
30. Panax ginseng extract improves the performance of aged Fischer 344 rats in radial maze task but not in operant brightness discrimination task
31. Panax ginseng extract improves the scopolamine-induced disruption of 8-arm radial maze performance in rats
32. Protective effect of ginseng saponins against impaired brain growth in neonatal rats exposed to ethanol
33. Effects of standardized ginseng extract on learning, memory and physical capabilities
34. Age-related differences in memory and in the memory effects of nootropic drugs
35. Behavioral effects of stem-leaves extract from Panax ginseng C.A. Meyer
36. Memory effects of standardized extracts of Panax ginseng (G 115), Ginkgo biloba (GK 501) and their combination Gincosan (PHL-00701)
37. Memory systems in normal and pathological aging
38. Neurotrophic actions of ginsenoside Rb1, peptide growth factors and cytokines
39. Effects of ginsenoside Rb1 and ginsenoside Rg1 on learning and memory
40. Effects of Panax ginseng root on conditioned avoidance response in rats
41. Potentiation of the NGF-mediated nerve fiber outgrowth by ginsenoside Rb1 in organ cultures of chicken dorsal root ganglia
42. Effects of Panax ginseng root on acquisition of sound discrimination behavior in rats
43. Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain
44. American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task
45. Potentiation of nerve growth factor-mediated nerve fiber production in organ cultures of chicken embryonic ganglia by ginseng saponins: Structure - Activity relationship
46. Entorhinal cortex pathology in Alzheimer's disease
47. Effect of ginseng on spontaneous motor activity, water-maze learning and central dopaminergic systems in old rats
48. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia
49. Alzheimer's disease and senile dementia: Loss of neurons in basal forebrain
50. Naturally ocurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons
51. Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze
52. Study on the nootropic mechanism of ginsenoside Rb1 and Rg1 - Influence on mouse brain development
53. Ginsenoside Rb1 prevents image navigation disability, cortical infarction, and thalamic degeneration in rats with focal cerebral ischemia
54. Preliminary study on antiamnestic mechanism of ginsenoside Rg1 and Rb1
55. Ginseng improves strategic learning by normal and brain-damaged rats
56. Red ginseng ameliorates place learning deficits in aged rats and in young rats with selective hippocampal lesions