Telomerase antagonist imetelstat inhibits esophageal cancer cell growth and increases radiation-induced DNA breaks

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 12, 2012, Pages 2130-2135

  Wu, Xuping ^a,d   Smavadati, Shirin ^a   Nordfjäll, Katarina ^b   Karlsson, Krister ^a   Qvarnström, Fredrik ^a   Simonsson, Martin ^a   Bergqvist, Michael ^a   Gryaznov, Sergei ^c   Ekman, Simon ^a   Paulsson Karlsson, Ylva ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c GERON CORPORATION   (United States)

^d Nanjing Second Hospital   (China)

Author keywords

H2AX and 53BP1 foci; DNA double strand break; Esophageal cancer; Imetelstat; Telomerase

Indexed keywords

HISTONE H2AX; IMETELSTAT; TELOMERASE;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL COUNT; CELL GROWTH; CELL SIZE; COLONY FORMATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INHIBITION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS CANCER; GENE INDUCTION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; TELOMERE HOMEOSTASIS;

CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA, NEOPLASM; ESOPHAGEAL NEOPLASMS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INDOLES; NIACINAMIDE; RADIATION, IONIZING; REAL-TIME POLYMERASE CHAIN REACTION; TELOMERASE; TELOMERE; TUMOR CELLS, CULTURED;

EID: 84867317083     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.08.003     Document Type: Article

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