Neuroglobin protection in retinal Ischemia

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 2, 2012, Pages 704-711

  Chan, Anita S Y ^a,b   Saraswathy, Sindhu ^a   Rehak, Matus ^a   Ueki, Mari ^a   Rao, Narsing A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; NEUROGLOBIN; GLOBIN; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENE OVEREXPRESSION; HISTOLOGY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; MORPHOMETRICS; MOUSE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR INNER SEGMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; RETINA BIPOLAR GANGLION CELL; RETINA GANGLION CELL; RETINA INNER PLEXIFORM LAYER; RETINA ISCHEMIA; RETINA THICKNESS; TRANSGENIC MOUSE; VISUAL SYSTEM PARAMETERS; WESTERN BLOTTING; ANIMAL; CASE CONTROL STUDY; DISEASE MODEL; METABOLISM; PHYSIOLOGY; RETINA DISEASE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CASPASE 3; DISEASE MODELS, ANIMAL; GLOBINS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; RETINAL DISEASES;

EID: 84859254915     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7408     Document Type: Article

References (53)

1. Burmester T, Weich B, Reinhardt S, Hankeln T. A vertebrate globin expressed in the brain. Nature. 2000;407:520-523.
2. Dewilde S, Kiger L, Burmester T, et al. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J Biol Chem. 2001;276:38949-38955.
3. Burmester T, Hankeln T. Neuroglobin: a respiratory protein of the nervous system. News Physiol Sci. 2004;19:110-113.
4. Brunori M, Vallone B. Neuroglobin, seven years after. Cell Mol Life Sci. 2007;64:1259-1268.
5. Schmidt M, Giessl A, Laufs T, Hankeln T, Wolfrum U, Burmester T. How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina. J Biol Chem. 2003;278: 1932-1935.
6. Burmester T, Hankeln T. What is the function of neuroglobin? J Exp Biol. 2009;212:1423-1428.
7. Bentmann A, Schmidt M, Reuss S, Wolfrum U, Hankeln T, Burmester T. Divergent distribution in vascular and avascular mammalian retinae links neuroglobin to cellular respiration. J Biol Chem. 2005;27:280:20660-20665.
8. Wang X, Liu J, Zhu H, et al. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke. 2008;39:1869-1874.
9. Khan AA, Wang Y, Sun Y, et al. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A. 2006;103:17944-17948.
10. Liu J, Yu Z, Guo S, et al. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009;87:164-170.
11. Ostojić J, Grozdanić SD, Syed NA, et al. Patterns of distribution of oxygen-binding globins, neuroglobin and cytoglobin in human retina. Arch Ophthalmol. 2008;126:1530-1536.
12. Dong Y, Zhao R, Chen XQ, Yu AC. 14-3-3gamma and neuroglobin are new intrinsic protective factors for cerebral ischemia. Mol Neurobiol. 2010;41:218-231.
13. Ostojić J, Sakaguchi DS, de Lathouder Y, et al. Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons. Invest Ophthalmol Vis Sci. 2006;47:1016-1023.
14. Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, Melena J. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res. 2004;23:91-147.
15. Lam TT, Abler AS, Tso MO. Apoptosis and caspases after ischemiareperfusion injury in rat retina. Invest Ophthalmol Vis Sci. 1999; 40:967-975.
16. Singh N, Sun Y, Nakamura K, Smith MR, Colburn NH. C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells. Oncol Res. 1995;7:353-362.
17. Bonne C, Muller A, Villain M. Free radicals in retinal ischemia. Gen Pharmacol. 1998;30:275-280.
18. Flaherty JT, Weisfeldt ML. Reperfusion injury. Free Radic Biol Med. 1988;5:409-419.
19. Buchi ER, Suivaizdis I, Fu J. Pressure-induced retinal ischemia in rats: an experimental model for quantitative study. Ophthalmologica. 1991;203:138-147.
20. Khan AA, Sun Y, Jin K, et al. A neuroglobin-overexpressing transgenic mouse. Gene. 2007;398:172-176.
21. Chen YG, Zhang C, Chiang SK, Wu T, Tso MO. Increased nuclear factor-kappa B p65 immunoreactivity following retinal ischemia and reperfusion injury in mice. J Neurosci Res. 2003;72:125-131.
22. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402-408.
23. Saraswathy S, Nguyen AM, Rao NA. The role of TLR4 in photoreceptor αA crystallin upregulation during early experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2010;51:3680-3686.
24. Khurana RN, Parikh JG, Saraswathy S, Wu G-S, Rao NA. Mitochondrial oxidative DNA damage in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2008;49:3299-3304.
25. Santos JH, Meyer JN, Mandavilli BS, Van Houten B. Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol. 2006;314: 183-199.
26. Santos JH, Mandavilli BS, Van Houten B. Measuring oxidative mtDNA damage and repair using quantitative PCR. Methods Mol Biol. 2002;197:159-176.
27. Rajendram R, Rao NA. Neuroglobin in normal retina and retina from eyes with advanced glaucoma. Br J Ophthalmol. 2007;91: 663-666.
28. Hundahl C, Stoltenberg M, Fago A, et al. Effects of short-term hypoxia on neuroglobin levels and localization in mouse brain tissues. Neuropathol Appl Neurobiol. 2005;31:610-617.
29. Jin K, Mao Y, Mao X, Xie L, Greenberg DA. Neuroglobin expression in ischemic stroke. Stroke. 2010;41:557-559.
30. Shang A, Zhou D, Wang L, et al. Increased neuroglobin levels in the cerebral cortex and serum after ischemia-reperfusion insults. Brain Res. 2006;1078:219-226.
31. Sun Y, Jin K, Peel A, Mao XO, Xie L, Greenberg DA. Neuroglobin protects the brain from experimental stroke in vivo. Proc Natl Acad Sci U S A. 2003;100:3497-3500.
32. Ding GP, Yan ZG, He T, et al. The neuroglobin expression when retinal ganglion cells death in acute rats' retina ischemia [in Chinese]. Zhonghua Yan Ke Za Zhi. 2010;46:590-596.
33. Schmidt-Kastner R, Haberkamp M, Schmitz C, Hankeln T, Burmester T. Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell culture. Brain Res. 2006; 1103:173-180.
34. Sun Y, Jin K, Mao XO, Zhu Y, Greenberg DA. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc Natl Acad Sci U S A. 2001;98:15306-15311.
35. Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-2137.
36. Milton SL, Nayak G, Lutz PL, Prentice HM. Gene transcription of neuroglobin is upregulated by hypoxia and anoxia in the brain of the anoxia-tolerant turtle Trachemys scripta. J Biomed Sci. 2006; 13:509-514.
37. Szabo ME, Droy-Lefaix MT, Doly M, Carre C, Braquet P. Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism. Invest Ophthalmol Vis Sci. 1991;32:1471-1478.
38. Hughes WF. Quantitation of ischemic damage in the rat retina. Exp Eye Res. 1991;53:573-582.
39. Sakamoto K, Ohki K, Saito M, Nakahara T, Ishii K. Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina. J Pharmacol Sci. 2010;112: 327-335.
40. Greenberg DA, Jin K, Khan AA. Neuroglobin: an endogenous neuroprotectant. Curr Opin Pharmacol. 2008;8:20-24.
41. Bonding SH, Henty K, Dingley AJ, Brittain T. The binding of cytochrome c to neuroglobin: a docking and surface plasmon resonance study. Int J Biol Macromol. 2008;43:295-299.
42. Chen XQ, Qin LY, Zhang CG, et al. Presence of neuroglobin in cultured astrocytes. Glia. 2005;50:182-186.
43. Yu Z, Fan X, Lo EH, Wang X. Neuroprotective roles and mechanisms of neuroglobin. Neurol Res. 2009;31:122-127.
44. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2' -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009;27:120-139.
45. Ohtaki H, Takeda T, Dohi K, et al. Increased mitochondrial DNA oxidative damage after transient middle cerebral artery occlusion in mice. Neurosci Res. 2007;58:349-355.
46. Brittain T, Skommer J, Henty K, Birch N, Raychaudhuri S. A role for human neuroglobin in apoptosis. IUBMB Life. 2010;62:878-885.
47. Raychaudhuri S, Skommer J, Henty K, Birch N, Brittain T. Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Apoptosis. 2010;15:401-411.
48. Wakasugi K, Morishima I. Identification of residues in human neuroglobin crucial for Guanine nucleotide dissociation inhibitor activity. Biochemistry. 2005;44:2943-2948.
49. Fago A, Mathews AJ, Brittain T. A role for neuroglobin: resetting the trigger level for apoptosis in neuronal and retinal cells. IUBMB Life. 2008;60:398-401.
50. Li RC, Morris MW, Lee SK, Pouranfar F, Wang Y, Gozal D. Neuroglobin protects PC12 cells against oxidative stress. Brain Res. 2008;1190:159-166.
51. Antao ST, Duong TT, Aran R, Witting PK. Neuroglobin overexpression in cultured human neuronal cells protects against hydrogen peroxide insult via activating phosphoinositide-3 kinase and opening the mitochondrial KATP channel. Antioxid Redox Signal. 2010;13:769-781.
52. Kitatsuji C, Kurogochi M, Nishimura S, Ishimori K, Wakasugi K. Molecular basis of guanine nucleotide dissociation inhibitor activity of human neuroglobin by chemical cross-linking and mass spectrometry. J Mol Biol. 2007;368:150-160.
53. Kuriyama H, Nakagawa M, Tsuda M. Intracellular Ca(2+) changes induced by in vitro ischemia in rat retinal slices. Exp Eye Res. 2001;73:365-374.