Anti-atherogenic effects of a phenol-rich fraction from brazilian red wine (vitis labrusca l.) in hypercholesterolemic low-density lipoprotein receptor knockout mice

Journal of Medicinal Food

Volumn 15, Issue 10, 2012, Pages 936-944

  Hort, Mariana Appel ^a   Schuldt, Elke Zuleika ^a   Bet, Ǎngela Cristina ^a   Dalbó, Silvia ^a   Siqueira, Jarbas Mota ^a   Ianssen, Carla ^a   Abatepaulo, Fátima ^b   De Souza, Heraldo Possolo ^b   Veleirinho, Beatriz ^a   Maraschin, Marcelo ^a   Ribeiro Do Valle, Rosa Maria ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

atherosclerosis; hypercholesterolemia; phenolic compounds; red wine; Vitis labrusca

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETYLCHOLINE; CAFFEIC ACID; CHLOROGENIC ACID; CHOLESTEROL; CINNAMIC ACID; COUMARIC ACID; GALLIC ACID; HYDROQUINONE; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PARA COUMARIC ACID; PLANT EXTRACT; QUERCETIN; RESVERATROL; SIMVASTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; VITIS LABRUSCA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; BLOOD VESSEL REACTIVITY; CHEMICAL COMPOSITION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; DRUG DOSE COMPARISON; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; KNOCKOUT MOUSE; LIPID DIET; LIPID STORAGE; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THORACIC AORTA; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; ULTRAVIOLET SPECTROSCOPY; VASODILATATION; VITIS; VITIS LABRUSCA;

ACETATES; ANIMALS; ARTERIES; ATHEROSCLEROSIS; BRAZIL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIET; HYPERCHOLESTEROLEMIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; PHENOLS; RECEPTORS, LDL; TRIGLYCERIDES; VASODILATION; WINE;

EID: 84867291453     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.0333     Document Type: Article

References (58)

1. Szmitko PE, Verma S: Antiatherogenic potential of red wine: clinician update. Am J Physiol Heart Circ Physiol 2005;288: H2023-H2030.
2. Djousse L, Gaziano JM: Alcohol consumption and risk of heart failure in the Physicians' Health Study I. Circulation 2007;115: 34-39.
3. Ignarro LJ, Balestrieri ML, Napoli C: Nutrition, physical activity, and cardiovascular disease: an update. Cardiovasc Res 2007;73: 326-340.
4. Napoli C, Balestrieri ML, Sica V, et al.: Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis. Heart Vessels 2008;23:124-133.
5. Stoclet JC, Chataigneau T, Ndiaye M, et al.: Vascular protection by dietary polyphenols. Eur J Pharmacol 2004;500:299-313.
6. Balestrieri ML, Schiano C, Felice F, et al.: Effect of low doses of red wine and pure resveratrol on circulating endothelial progenitor cells. J Biochem 2008;143:179-186.
7. Beecher GR, Warden BA, Merken H: Analysis of tea polyphenols. Proc Soc Exp Biol Med 1999;220:267-270.
8. Curin Y, Andriantsitohaina R: Polyphenols as potential therapeutical agents against cardiovascular diseases. Pharmacol Rep 2005;57(Suppl):97-107.
9. Frankel EN, Kanner J, German JB, Parks E, Kinsella JE: Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993;341:454-457.
10. Howard LR, Pandjaitan N, Morelock T, Gil MI: Antioxidant capacity and phenolic content of spinach as affected by genetics and growing season. J Agric Food Chem 2002;50:5891-5896.
11. Blanco-Colio LM, Munoz-Garcia B, Martin-Ventura JL, et al.: Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fatenriched diet. Atherosclerosis 2007;192:335-341.
12. Baron-Menguy C, Bocquet A, Guihot AL, et al.: Effects of red wine polyphenols on postischemic neovascularization model in rats: low doses are proangiogenic, high doses anti-angiogenic. FASEB J 2007;21:3511-3521.
13. Shimada K, Watanabe H, Hosoda K, Takeuchi K, Yoshikawa J: Effect of red wine on coronary flow-velocity reserve. Lancet 1999;354:1002.
14. Madeira SV, de Castro Resende A, Ognibene DT, de Sousa MA, Soares de Moura R: Mechanism of the endothelium-dependent vasodilator effect of an alcohol-free extract obtained from a Vinifera grape skin. Pharmacol Res 2005;52:321-327.
15. Fremont L: Biological effects of resveratrol. Life Sci 2000;66: 663-673.
16. Vinson JA, Teufel K, Wu N: Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in a hamster model. Atherosclerosis 2001;156:67-72.
17. Vazquez-Agell M, Sacanella E, Tobias E, et al.: Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk. J Nutr 2007;137:2279-2284.
18. Aviram M, Fuhrman B: Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis 1998;137(Suppl):S45-S50.
19. Ndiaye M, Chataigneau M, Lobysheva I, Chataigneau T, Schini-Kerth VB: Red wine polyphenol-induced, endotheliumdependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NOsynthase in the isolated porcine coronary artery. FASEB J 2005; 19:455-457.
20. Ndiaye M, Chataigneau T, Chataigneau M, Schini-Kerth VB: Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathway. Br J Pharmacol 2004;142:1131-1136.
21. Anselm E, Chataigneau M, Ndiaye M, Chataigneau T, Schini-Kerth VB: Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src-and Akt-dependent activation of eNOS. Cardiovasc Res 2007;73:404-413.
22. Schuldt EZ, Bet AC, Hort MA, et al.: An ethyl acetate fraction obtained from a Southern Brazilian red wine relaxes rat mesenteric arterial bed through hyperpolarization and NO-cGMP pathway. Vasc Pharmacol 2005;43:62-68.
23. Pagliosa CM, Vieira MA, Podestá R, et al.: Methylxanthines, phenolic composition, and antioxidant activity of bark from residues from mate tree harvesting (Ilex paraguariensis A. St. Hil.). Food Chem 2010;122:173-178.
24. Krieger MH, Santos KF, Shishido SM, et al.: Antiatherogenic effects of S-nitroso-N-acetylcysteine in hypercholesterolemic LDL receptor knockout mice. Nitric Oxide 2006;14:12-20.
25. Hort MA, Straliotto MR, Netto PM, et al.: Diphenyl diselenide effectively reduces atherosclerotic lesions in LDLr-/-mice by attenuation of oxidative stress and inflammation. J Cardiovasc Pharmacol 2011;58:91-101.
26. Lusis AJ: Atherosclerosis. Nature 2000;407:233-241.
27. Duval C, Chinetti G, Trottein F, Fruchart JC, Staels B: The role of PPARs in atherosclerosis. Trends Mol Med 2002;8:422-430.
28. Steinberg D: Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med 2002;8:1211-1217.
29. Libby P, Aikawa M, Kinlay S, Selwyn A, Ganz P: Lipid lowering improves endothelial functions. Int J Cardiol 2000;74(Suppl 1):S3-S10.
30. Catanozi S, Rocha JC, Passarelli M, et al.: Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice. J Lipid Res 2003;44:727-732.
31. Sharma AM, Chetty VT: Obesity, hypertension and insulin resistance. Acta Diabetol 2005;42(Suppl 1):S3-S8.
32. Tamminen M, Mottino G, Qiao JH, Breslow JL, Frank JS: Ultrastructure of early lipid accumulation in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 1999;19:847-853.
33. Ishibashi S, Brown MS, Goldstein JL, et al.: Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993;92:883-893.
34. Andersson KE, Svedberg KA, Lindholm MW, Oste R, Hellstrand P: Oats (Avena sativa) reduce atherogenesis in LDL-receptordeficient mice. Atherosclerosis 2010;212:93-99.
35. Mulvihill EE, Assini JM, Sutherland BG, et al.: Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol 2010;30:742-748.
36. Cyrus T, Sung S, Zhao L, et al.: Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 2002;106:1282-1287.
37. da Luz PL, Serrano Junior CV, Chacra AP, et al.: The effect of red wine on experimental atherosclerosis: lipid-independent protection. Exp Mol Pathol 1999;65:150-159.
38. Soulat T, Philippe C, Bal dit Sollier C, et al.: Wine constituents inhibit thrombosis but not atherogenesis in C57BL/6 apolipoprotein E-deficient mice. Br J Nutr 2006;96:290-298.
39. Perez-Jimenez J, Saura-Calixto F: Grape products and cardiovascular disease risk factors. Nutr Res Rev 2008;21:158-173.
40. Auger C, Laurent N, Laurent C, et al.: Hydroxycinnamic acids do not prevent aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters. Life Sci 2004;74:2365-2377.
41. Woo MN, Bok SH, Choi MS: Hypolipidemic and body fatlowering effects of Fatclean in rats fed a high-fat diet. Food Chem Toxicol 2009;47:2076-2082.
42. Woo MN, Bok SH, Lee MK, et al.: Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&S PWH) in rats fed high-fat diets. J Med Food 2008;11: 169-178.
43. Libby P, Ridker PM, Maseri A: Inflammation and atherosclerosis. Circulation 2002;105:1135-1143.
44. Fazio S, Linton MF: The inflamed plaque: cytokine production and cellular cholesterol balance in the vessel wall. Am J Cardiol 2001;88:12E-15E.
45. Laroia ST, Ganti AK, Laroia AT, Tendulkar KK: Endothelium and the lipid metabolism: the current understanding. Int J Cardiol 2003;88:1-9.
46. Davis N, Katz S, Wylie-Rosett J: The effect of diet on endothelial function. Cardiol Rev 2007;15:62-66.
47. Vigna GB, Costantini F, Aldini G, et al.: Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism 2003;52:1250-1257.
48. Higashi Y, Noma K, Yoshizumi M, Kihara Y: Endothelial function and oxidative stress in cardiovascular diseases. Circ J 2009;73:411-418.
49. Kinlay S, Libby P, Ganz P: Endothelial function and coronary artery disease. Curr Opin Lipidol 2001;12:383-389.
50. Lamping KG, NunoDW,ChappellDA, Faraci FM:Agonist-specific impairment of coronary vascular function in genetically altered, hyperlipidemic mice. Am J Physiol 1999;276:R1023-R1029.
51. Satue-Gracia MT, Andres-Lacueva C, Lamuela-Raventos RM, Frankel EN: Spanish sparkling wines (Cavas) as inhibitors of in vitro human low-density lipoprotein oxidation. J Agric Food Chem 1999;47:2198-2202.
52. Deckert V, Desrumaux C, Athias A, et al.: Prevention of LDL alpha-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine. Atherosclerosis 2002;165:41-50.
53. Gu J, Wang CQ, Fan HH, et al.: Effects of resveratrol on endothelial progenitor cells and their contributions to reendothelialization in intima-injured rats. J Cardiovasc Pharmacol 2006;47:711-721.
54. Choi EJ, Chee KM, Lee BH: Anti-and prooxidant effects of chronic quercetin administration in rats. Eur J Pharmacol 2003; 482:281-285.
55. Schwartz JL: The dual roles of nutrients as antioxidants and prooxidants: their effects on tumor cell growth. J Nutr 1996; 126:1221S-1227S.
56. Lankin VZ, Tikhaze AK, Konovalova GG, Kozachenko AI: [Concentration inversion of the antioxidant and pro-oxidant effects of beta-carotene in tissues in vivo]. Biull Eksp Biol Med 1999;128:314-316.
57. Wang YX, Martin-McNulty B, Huw LY, et al.: Antiatherosclerotic effect of simvastatin depends on the presence of apolipoprotein E. Atherosclerosis 2002;162:23-31.
58. Liao JK, Laufs U: Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 2005;45:89-118.