Diphenyl diselenide effectively reduces atherosclerotic lesions in LDLr -/- Mice by attenuation of oxidative stress and inflammation

Journal of Cardiovascular Pharmacology

Volumn 58, Issue 1, 2011, Pages 91-101

  Hort, Mariana Appel ^a   Straliotto, Marcos Raniel ^a   Netto, Paula Moro ^a   Da Rocha, João Batista Teixeira ^b   De Bem, Andreza Fabro ^a   Ribeiro Do Valle, Rosa Maria ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

atherosclerosis; diphenyl diselenide; glutathione peroxidase; inflammation; oxidative stress

Indexed keywords

3 NITROTYROSINE; DIPHENYL DISELENIDE; LOW DENSITY LIPOPROTEIN RECEPTOR; MALONALDEHYDE; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CONTROLLED STUDY; DRUG EFFICACY; FOAM CELL; HYPERCHOLESTEROLEMIA; INFLAMMATORY CELL; LOW DRUG DOSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VASODILATATION;

EID: 84984589207     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31821d1149     Document Type: Article

References (47)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999; 340:115-126.
2. Raes M, Michiels C, Remacle J. Comparative study of the enzymatic defense systems against oxygen-derived free radicals: the key role of glutathione peroxidase. Free Radic Biol Med. 1987;3:3-7.
3. Blankenberg S, Rupprecht HJ, Bickel C, et al. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med. 2003;349:1605-1613. (Pubitemid 37288568)
4. Lewis P, Stefanovic N, Pete J, et al. Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice. Circulation. 2007;115:2178-2187. (Pubitemid 46659070)
5. Lapenna D, de Gioia S, Ciofani G, et al. Glutathione-related antioxidant defenses in human atherosclerotic plaques. Circulation. 1998;97: 1930-1934. (Pubitemid 28222187)
6. Forgione MA, Weiss N, Heydrick S, et al. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2002;282:H1255-H1261. (Pubitemid 34654876)
7. Torzewski M, Ochsenhirt V, Kleschyov AL, et al. Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007; 27:850-857. (Pubitemid 46606716)
8. Guo Z, Ran Q, Roberts LJ II, et al. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med. 2008;44:343-352.
9. Wilson SR, Zucker PA, Huang, RRC, et al. Development of synthetic compounds with glutathione peroxidase activity. J Am Chem Soc. 1989; 111:5936-5939.
10. Nogueira CW, Zeni G, Rocha JB. Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev. 2004;104: 6255-6285. (Pubitemid 40025738)
11. Muller A, Cadenas E, Graf P, et al. A novel biologically active selenoorganic compound-I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). Biochem Pharmacol. 1984;33: 3235-3239. (Pubitemid 14023257)
12. Sies H, Masumoto H. Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite. Adv Pharmacol. 1997;38:229-246.
13. Ali N, Yoshizumi M, Tsuchiya K, et al. Ebselen inhibits p38 mitogenactivated protein kinase-mediated endothelial cell death by hydrogen peroxide. Eur J Pharmacol. 2004;485:127-135. (Pubitemid 38134406)
14. Chew P, Yuen DY, Koh P, et al. Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse. Arterioscler Thromb Vasc Biol. 2009;29:823-830.
15. Posser T, Franco JL, dos Santos DA, et al. Diphenyl diselenide confers neuroprotection against hydrogen peroxide toxicity in hippocampal slices. Brain Res. 2008;1199:138-147.
16. Barbosa NB, Rocha JB, Wondracek DC, et al. Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress. Chem Biol Interact. 2006;163:230-238. (Pubitemid 44572228)
17. de Bem AF, Portella Rde L, Colpo E, et al. Diphenyl diselenide decreases serum levels of total cholesterol and tissue oxidative stress in cholesterol-fed rabbits. Basic Clin Pharmacol Toxicol. 2009;105:17-23.
18. de Bem AF, Farina M, Portella Rde L, et al. Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro. Atherosclerosis. 2008;201:92-100.
19. Nogueira CW, Meotti FC, Curte E, et al. Investigations into the potential neurotoxicity induced by diselenides in mice and rats. Toxicology. 2003; 183:29-37. (Pubitemid 36005387)
20. de Bem AF, de Lima Portella R, Farina M, et al. Low toxicity of diphenyl diselenide in rabbits: a long-term study. Basic Clin Pharmacol Toxicol. 2007;101:47-55. (Pubitemid 46934649)
21. Straliotto MR, Mancini G, de Oliveira J, et al. Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation. J Appl Toxicol. 2010;30: 761-768.
22. Nogueira CW, Quinhones EB, Jung EA, et al. Anti-inflammatory and antinociceptive activity of diphenyl diselenide. Inflamm Res. 2003;52: 56-63. (Pubitemid 36286702)
23. Brito C, Naviliat M, Tiscornia AC, et al. Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death. J Immunol. 1999;162:3356-3366. (Pubitemid 29313585)
24. Paulmier C. Selenium Reagents and Intermediates in Organic Synthesis. Pergamon Books, New York: 463, 1986.
25. Krieger MH, Santos KF, Shishido SM, et al. Antiatherogenic effects of Snitroso- N-acetylcysteine in hypercholesterolemic LDL receptor knockout mice. Nitric Oxide. 2006;14:12-20. (Pubitemid 43063503)
26. Paigen B, Morrow A, Holmes PA, et al. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68:231-240. (Pubitemid 17159775)
27. Rubin EM, Krauss RM, Spangler EA, et al. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature. 1991;353:265-267. (Pubitemid 21896769)
28. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
29. Savegnago L, Jesse CR, Pinto LG, et al. Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice. Brain Res. 2007;1175:54-59. (Pubitemid 47513005)
30. Prigol M, Schumacher RF, WayneNogueira C, et al. Convulsant effect of diphenyl diselenide in rats and mice and its relationship to plasma levels. Toxicol Lett. 2009;189:35-39.
31. Ishibashi S, Brown MS, Goldstein JL, et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirusmediated gene delivery. J Clin Invest. 1993;92:883-893. (Pubitemid 23262411)
32. Mohiuddin I, Chai H, Lin PH, et al. Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system. J Surg Res. 2006;133:143-149. (Pubitemid 43765765)
33. Radi R, Beckman JS, Bush KM, et al. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys. 1991;288:481-487.
34. Peluffo G, Calcerrada P, Piacenza L, et al. Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am J Physiol Heart Circ Physiol. 2009;296:H1781-H1792.
35. Briviba K, Roussyn I, Sharov VS, et al. Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen. Biochem J. 1996;319(pt 1):13-15. (Pubitemid 26394732)
36. Higashi Y, Noma K, Yoshizumi M, et al. Endothelial function and oxidative stress in cardiovascular diseases. Circ J. 2009;73:411-418.
37. Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046-1051. (Pubitemid 17170620)
38. Brodsky SV, Gealekman O, Chen J, et al. Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesityinduced diabetes by ebselen. Circ Res. 2004;94:377-384. (Pubitemid 38240730)
39. Deng T, Xu K, Zhang L, et al. Dynamic determination of Ox-LDLinduced oxidative/nitrosative stress in single macrophage by using fluorescent probes. Cell Biol Int. 2008;32:1425-1432.
40. Levitan I, Volkov S, Subbaiah PV. Oxidized LDL: diversity, patterns of recognition, and pathophysiology. Antioxid Redox Signal. 2010;13:39-75.
41. Rosenblat M, Aviram M. Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies. Free Radic Biol Med. 1998;24:305-317. (Pubitemid 28008809)
42. Kim SJ, Park C, Han AL, et al. Ebselen attenuates cisplatin-induced ROS generation throughNrf2 activation in auditory cells. Hear Res. 2009;251:70-82.
43. Tamasi V, Jeffries JM, Arteel GE, et al. Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription. Arch Biochem Biophys. 2004;431:161-168. (Pubitemid 39369921)
44. Schmitz G, Grandl M. Lipid homeostasis in macrophages-implications for atherosclerosis. Rev Physiol Biochem Pharmacol. 2008;160:93-125.
45. Terkeltaub R, Banka CL, Solan J, et al. Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity. Arterioscler Thromb. 1994;14:47-53.
46. Shin KM, Shen L, Park SJ, et al. Bis-(3-hydroxyphenyl) diselenide inhibits LPS-stimulated iNOS and COX-2 expression in RAW 264.7 macrophage cells through the NF-kappaB inactivation. J Pharm Pharmacol. 2009;61:479-486.
47. da Rocha JT, Speranca A, Nogueira CW, et al. Hypolipidaemic activity of orally administered diphenyl diselenide in Triton WR-1339-induced hyperlipidaemia in mice. J Pharm Pharmacol. 2009;61:1673-1679.