Ultrastructure of early lipid accumulation in apoE-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 4, 1999, Pages 847-853

  Tamminen, M ^b   Mottino, G ^a   Qiao, J H ^a   Breslow, J L ^b   Frank, Joy S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

ApoE deficient mice; Early atherosclerosis; Freeze etch morphology; Lipid retention

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; COLLAGEN FIBRIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; FOAM CELL; FREEZE ETCHING; HYPERCHOLESTEROLEMIA; INTIMA; LIPID STORAGE; LIPOPROTEIN DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032916832     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.4.847     Document Type: Article

References (17)

1. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-353.
2. Zhang S, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
3. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133-140.
4. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apoE: evaluation of lesional development and progression. Arterioscler Thromb. 1994;14:141-147.
5. Nievelstein PFEM, Fogelman AM, Mottino G, Frank JS. Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low-density lipoprotein: a deep-etch and immunolocalization study of ultrarapidly frozen tissue. Arterioscler Thromb. 1991;11:1795-1805.
6. Nievelstein-Post P, Mottino G, Fogelman AM, Frank JS. An ultrastructural study of lipoprotein accumulation in cardiac valves of the rabbit. Arterioscler Thromb. 1994;14:1151-1161.
7. Smith JD, Trogan E, Ginsberg M, Grigaux C, Tian J, Miyata M. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (OP) and apolipoprotein E. Proc Natl Acad Sci U S A. 1995;92:8264-8268.
8. Frank JS, Fogelman AM. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching. J Lipid Res. 1989;30:967-978.
9. Williams KJ, Tabas I. The response to retention hypothesis of early atherogenesis. Arterioscler Thromb. 1995;15:551-561.
10. Schwenke DC, Carew TE. Initiation of atherosclerotic lesions in cholesterol-fed rabbits: focal increases in arterial LDL concentration precede development of fatty streak lesions. Arterioscler Thromb. 1989;9:895-907.
11. Camejo G, Lopez F, Quinones J. Interaction of low-density lipoproteins with arterial proteoglycans. Atherosclerosis. 1985;55:93-105.
12. Falone DJ, Salisbury BGJ. Fibronectin stimulates macrophage uptake of low density lipoproteins-heparin-collagen complexes. Arteriosclerosis. 1988;8:263-273.
13. Pentikainen MO, Oorni K, Lassila R, Kovanen PT. The proteoglycan decorin links low density lipoproteins with collagen type I. J Biol Chem. 1997;272:7633-7638.
14. Vogel KG, Paulsson M, Heinegard D. Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem J. 1984;223:587-597.
15. Brown DC, Vogel KG. Characteristics of the in vitro interaction of a small proteoglycan (PGII) of bovine tendon with type I collagen. Matrix. 1989;9:468-478.
16. Riessen R, Isner JM, Blessing E, Loushin C, Nikol S, Wight TN. Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries. Am J Pathol. 1994;144:962-974.
17. Pillarisettl S, Paka L, Obunike JC, Berglund I, Goldberg IJ. Subendothelial retention of lipoprotein(a): evidence that reduced heparan sulfate promotes lipoprotein binding to subendothelial matrix. J Clin Invest. 1997;100:867-874.