Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E

Atherosclerosis

Volumn 162, Issue 1, 2002, Pages 23-31

  Wang, Y X ^a   Martin McNulty, Baby ^a   Huw, Ling Yuh ^a   Da Cunha, Valdeci ^a   Post, Joe ^a   Hinchman, Josephine ^a   Vergona, Ronald ^a   Sullivan, Mark E ^a   Dole, William ^a   Kauser, Katalin ^a  

^a BAYER AG   (Germany)

Author keywords

Apo E knockout; Atherosclerotic plaque; Cholesterol; Endothelial dysfunction; HMG CoA reductase inhibitor; LDLR knockout; Mouse; NOS 3

Indexed keywords

ACETYLCHOLINE; APOLIPOPROTEIN E; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME; SIMVASTATIN; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL INJURY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM INJURY; FEEDING; GENDER; HORMONE DETERMINATION; HYPERCHOLESTEROLEMIA; ISOLATION PROCEDURE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; MICE; MICE, KNOCKOUT; MODELS, CARDIOVASCULAR; MUSCLE RELAXATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RECEPTORS, LDL; RNA, MESSENGER; SIMVASTATIN; TREATMENT OUTCOME; TRIGLYCERIDES; VASODILATOR AGENTS;

EID: 0036223846     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(01)00678-5     Document Type: Article

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