Combinatorial regulation of tissue specification by GATA and FOG factors

Development (Cambridge)

Volumn 139, Issue 21, 2012, Pages 3905-3916

  Chlon, Timothy M ^a   Crispino, John D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Gene regulation; Lineage commitment; Transcription factors

Indexed keywords

TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR GATA 4;

CELL LINEAGE; COMPLEX FORMATION; DROSOPHILA; ENDOTHELIUM CELL; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPRESSION; GENITAL SYSTEM; HEART MUSCLE CELL; HEMATOPOIETIC SYSTEM; HUMAN; MESENCHYME CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; VERTEBRATE;

ANIMALS; GATA TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84867280730     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.080440     Document Type: Review

References (137)

1. Abel, T., Michelson, A. M. and Maniatis, T. (1993). A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development 119, 623-633.
2. Ackerman, K. G., Herron, B. J., Vargas, S. O., Huang, H., Tevosian, S. G., Kochilas, L., Rao, C., Pober, B. R., Babiuk, R. P., Epstein, J. A. et al. (2005). FOG-2 is required for normal diaphragm and lung development in mice and humans. PLoS Genet. 1, e10.
3. Ackerman, K. G., Wang, J., Luo, L., Fujiwara, Y., Orkin, S. H. and Beier, D. R. (2007). Gata4 is necessary for normal pulmonary lobar development. Am. J. Respir. Cell Mol. Biol. 36, 391-397.
4. Amigo, J. D., Ackermann, G. E., Cope, J. J., Yu, M., Cooney, J. D., Ma, D., Langer, N. B., Shafizadeh, E., Shaw, G. C., Horsely, W. et al. (2009). The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood 114, 4654-4663.
5. Anttonen, M., Ketola, I., Parviainen, H., Pusa, A.-K. and Heikinheimo, M. (2003). FOG-2 and GATA-4 are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Biol. Reprod. 68, 1333-1340.
6. Arceci, R. J., King, A. A., Simon, M. C., Orkin, S. H. and Wilson, D. B. (1993). Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell. Biol. 13, 2235-2246.
7. Beuling, E., Bosse, T., aan de Kerk, D. J., Piaseckyj, C. M., Fujiwara, Y., Katz, S. G., Orkin, S. H., Grand, R. J. and Krasinski, S. D. (2008). GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev. Biol. 322, 179-189.
8. Bisping, E., Ikeda, S., Kong, S. W., Tarnavski, O., Bodyak, N., McMullen, J. R., Rajagopal, S., Son, J. K., Ma, Q., Springer, Z. et al. (2006). Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc. Natl. Acad. Sci. USA 103, 14471-14476.
9. Blobel, G. A., Nakajima, T., Eckner, R., Montminy, M. and Orkin, S. H. (1998). CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc. Natl. Acad. Sci. USA 95, 2061-2066.
10. Bosse, T., Piaseckyj, C. M., Burghard, E., Fialkovich, J. J., Rajagopal, S., Pu, W. T. and Krasinski, S. D. (2006). Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol. Cell. Biol. 26, 9060-9070.
11. Cantor, A. B. and Orkin, S. H. (2005). Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Semin. Cell Dev. Biol. 16, 117-128.
12. Cantor, A. B., Iwasaki, H., Arinobu, Y., Moran, T. B., Shigematsu, H., Sullivan, M. R., Akashi, K. and Orkin, S. H. (2008). Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J. Exp. Med. 205, 611-624.
13. Chang, A. N., Cantor, A. B., Fujiwara, Y., Lodish, M. B., Droho, S., Crispino, J. D. and Orkin, S. H. (2002). GATA-factor dependence of the multitype zincfinger protein FOG-1 for its essential role in megakaryopoiesis. Proc. Natl. Acad. Sci. USA 99, 9237-9242.
14. Charron, F., Paradis, P., Bronchain, O., Nemer, G. and Nemer, M. (1999). Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Mol. Cell. Biol. 19, 4355-4365.
15. Cheng, Y., Wu, W., Kumar, S. A., Yu, D., Deng, W., Tripic, T., King, D. C., Chen, K.-B., Zhang, Y., Drautz, D. et al. (2009). Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res. 19, 2172-2184.
16. Chlon, T. M., Dore, L. C. and Crispino, J. D. (2012). Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression. Mol. Cell 47, 608-621.
17. Ciovacco, W. A., Raskind, W. H. and Kacena, M. A. (2008). Human phenotypes associated with GATA-1 mutations. Gene 427, 1-6.
18. Crispino, J. D., Lodish, M. B., MacKay, J. P. and Orkin, S. H. (1999). Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol. Cell 3, 219-228.
19. Crispino, J. D., Lodish, M. B., Thurberg, B. L., Litovsky, S. H., Collins, T., Molkentin, J. D. and Orkin, S. H. (2001). Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 15, 839-844.
20. Crossley, M. and Orkin, S. H. (1994). Phosphorylation of the erythroid transcription factor GATA-1. J. Biol. Chem. 269, 16589-16596.
21. Cubadda, Y., Heitzler, P., Ray, R. P., Bourouis, M., Ramain, P., Gelbart, W., Simpson, P. and Haenlin, M. (1997). U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. Genes Dev. 11, 3083-3095.
22. Deconinck, A. E., Mead, P. E., Tevosian, S. G., Crispino, J. D., Katz, S. G., Zon, L. I. and Orkin, S. H. (2000). FOG acts as a repressor of red blood cell development in Xenopus. Development 127, 2031-2040.
23. Doré, L. C., Chlon, T. M., Brown, C. D., White, K. P. and Crispino, J. D. (2012). Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood 119, 3724-3733.
24. Eisbacher, M., Holmes, M. L., Newton, A., Hogg, P. J., Khachigian, L. M., Crossley, M. and Chong, B. H. (2003). Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding. Mol. Cell. Biol. 23, 3427-3441.
25. Evans, C. J., Hartenstein, V. and Banerjee, U. (2003). Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis. Dev. Cell 5, 673-690.
26. Evans, T., Reitman, M. and Felsenfeld, G. (1988). An erythrocyte-specific DNAbinding factor recognizes a regulatory sequence common to all chicken globin genes. Proc. Natl. Acad. Sci. USA 85, 5976-5980.
27. Flagg, A. E., Earley, J. U. and Svensson, E. C. (2007). FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Dev. Biol. 304, 308-316.
28. Fossett, N., Zhang, Q., Gajewski, K., Choi, C. Y., Kim, Y. and Schulz, R. A. (2000). The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 97, 7348-7353.
29. Fossett, N., Tevosian, S. G., Gajewski, K., Zhang, Q., Orkin, S. H. and Schulz, R. A. (2001). The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila. Proc. Natl. Acad. Sci. USA 98, 7342-7347.
30. Fossett, N., Hyman, K., Gajewski, K., Orkin, S. H. and Schulz, R. A. (2003). Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proc. Natl. Acad. Sci. USA 100, 11451-11456.
31. Fox, A. H., Liew, C., Holmes, M., Kowalski, K., Mackay, J. and Crossley, M. (1999). Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. EMBO J. 18, 2812-2822.
32. Fujiwara, T., O'Geen, H., Keles, S., Blahnik, K., Linnemann, A. K., Kang, Y.-A., Choi, K., Farnham, P. J. and Bresnick, E. H. (2009). Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol. Cell 36, 667-681.
33. Fujiwara, Y., Browne, C. P., Cunniff, K., Goff, S. C. and Orkin, S. H. (1996). Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc. Natl. Acad. Sci. USA 93, 12355-12358.
34. Gao, Z., Huang, Z., Olivey, H. E., Gurbuxani, S., Crispino, J. D. and Svensson, E. C. (2010). FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J. 29, 457-468.
35. Gittenberger-de Groot, A. C., Vrancken Peeters, M. P., Mentink, M. M., Gourdie, R. G. and Poelmann, R. E. (1998). Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circ. Res. 82, 1043-1052.
36. Grass, J. A., Boyer, M. E., Pal, S., Wu, J., Weiss, M. J. and Bresnick, E. H. (2003). GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc. Natl. Acad. Sci. USA 100, 8811-8816.
37. Grass, J. A., Jing, H., Kim, S.-I., Martowicz, M. L., Pal, S., Blobel, G. A. and Bresnick, E. H. (2006). Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol. Cell. Biol. 26, 7056-7067.
38. Gregory, G. D., Miccio, A., Bersenev, A., Wang, Y., Hong, W., Zhang, Z., Poncz, M., Tong, W. and Blobel, G. A. (2010). FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocyticerythroid compartment. Blood 115, 2156-2166.
39. Gregory, T., Yu, C., Ma, A., Orkin, S. H., Blobel, G. A. and Weiss, M. J. (1999). GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood 94, 87-96.
40. Haenlin, M., Cubadda, Y., Blondeau, F., Heitzler, P., Lutz, Y., Simpson, P. and Ramain, P. (1997). Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila. Genes Dev. 11, 3096-3108.
41. Hall, M. A., Curtis, D. J., Metcalf, D., Elefanty, A. G., Sourris, K., Robb, L., Gothert, J. R., Jane, S. M. and Begley, C. G. (2003). The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc. Natl. Acad. Sci. USA 100, 992-997.
42. Hirasawa, R., Shimizu, R., Takahashi, S., Osawa, M., Takayanagi, S., Kato, Y., Onodera, M., Minegishi, N., Yamamoto, M., Fukao, K. et al. (2002). Essential and instructive roles of GATA factors in eosinophil development. J. Exp. Med. 195, 1379-1386.
43. Hong, W., Nakazawa, M., Chen, Y.-Y., Kori, R., Vakoc, C. R., Rakowski, C. and Blobel, G. A. (2005). FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J. 24, 2367-2378.
44. Hung, H.-L., Lau, J., Kim, A. Y., Weiss, M. J. and Blobel, G. A. (1999). CREBbinding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol. Cell. Biol. 19, 3496-3505.
45. Jay, P. Y., Bielinska, M., Erlich, J. M., Mannisto, S., Pu, W. T., Heikinheimo, M. and Wilson, D. B. (2007). Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev. Biol. 301, 602-614.
46. Jing, H., Vakoc, C. R., Ying, L., Mandat, S., Wang, H., Zheng, X. and Blobel, G. A. (2008). Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol. Cell 29, 232-242.
47. Johnson, K. D., Boyer, M. E., Kang, J.-A., Wickrema, A., Cantor, A. B. and Bresnick, E. H. (2007). Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function. Blood 109, 5230-5233.
48. Katz, S. G., Cantor, A. B. and Orkin, S. H. (2002). Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Mol. Cell. Biol. 22, 3121-3128.
49. Katz, S. G., Williams, A., Yang, J., Fujiwara, Y., Tsang, A. P., Epstein, J. A. and Orkin, S. H. (2003). Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc. Natl. Acad. Sci. USA 100, 14030-14035.
50. Kelley, C., Yee, K., Harland, R. and Zon, L. I. (1994). Ventral expression of GATA-1 and GATA-2 in the Xenopus embryo defines induction of hematopoietic mesoderm. Dev. Biol. 165, 193-205.
51. Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Soudais, C. and Leiden, J. M. (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11, 1048-1060.
52. Lamonica, J. M., Vakoc, C. R. and Blobel, G. A. (2006). Acetylation of GATA-1 is required for chromatin occupancy. Blood 108, 3736-3738.
53. Lamonica, J. M., Deng, W., Kadauke, S., Campbell, A. E., Gamsjaeger, R., Wang, H., Cheng, Y., Billin, A. N., Hardison, R. C., Mackay, J. P. et al. (2011). Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proc. Natl. Acad. Sci. USA 108, E159-E168.
54. Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B. and Evans, T. (1994). GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J. Biol. Chem. 269, 23177-23184.
55. Lee, M. E., Temizer, D. H., Clifford, J. A. and Quertermous, T. (1991). Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. J. Biol. Chem. 266, 16188-16192.
56. Lejon, S., Thong, S. Y., Murthy, A., AlQarni, S., Murzina, N. V., Blobel, G. A., Laue, E. D. and Mackay, J. P. (2011). Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex. J. Biol. Chem. 286, 1196-1203.
57. Letting, D. L., Chen, Y.-Y., Rakowski, C., Reedy, S. and Blobel, G. A. (2004). Context-dependent regulation of GATA-1 by friend of GATA-1. Proc. Natl. Acad. Sci. USA 101, 476-481.
58. Lin, A. C., Roche, A. E., Wilk, J. and Svensson, E. C. (2004). The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. J. Biol. Chem. 279, 55017-55023.
59. Lindeboom, F., Gillemans, N., Karis, A., Jaegle, M., Meijer, D., Grosveld, F. and Philipsen, S. (2003). A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Res. 31, 5405-5412.
60. Lowry, J. A. and Atchley, W. R. (2000). Molecular evolution of the GATA family of transcription factors: conservation within the DNA-binding domain. J. Mol. Evol. 50, 103-115.
61. Lowry, J. A. and Mackay, J. P. (2006). GATA-1: One protein, many partners. Int. J. Biochem. Cell Biol. 38, 6-11.
62. Lu, J. R., McKinsey, T. A., Xu, H., Wang, D. Z., Richardson, J. A. and Olson, E. N. (1999). FOG-2, a heart-and brain-enriched cofactor for GATA transcription factors. Mol. Cell. Biol. 19, 4495-4502.
63. Lyons, S. E., Lawson, N. D., Lei, L., Bennett, P. E., Weinstein, B. M. and Liu, P. P. (2002). A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proc. Natl. Acad. Sci. USA 99, 5454-5459.
64. Maeda, K., Nishiyama, C., Tokura, T., Nakano, H., Kanada, S., Nishiyama, M., Okumura, K. and Ogawa, H. (2006). FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cellspecific gene expression in mice. Blood 108, 262-269.
65. Maeda, T., Ito, K., Merghoub, T., Poliseno, L., Hobbs, R. M., Wang, G., Dong, L., Maeda, M., Dore, L. C., Zelent, A. et al. (2009). LRF is an essential downstream target of GATA1 in erythroid development and regulates BIMdependent apoptosis. Dev. Cell 17, 527-540.
66. Martin, D. I. and Orkin, S. H. (1990). Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev. 4, 1886-1898.
67. Martin, D. I. K., Zon, L. I., Mutter, G. and Orkin, S. H. (1990). Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature 344, 444-447.
68. McCormack, M. P., Hall, M. A., Schoenwaelder, S. M., Zhao, Q., Ellis, S., Prentice, J. A., Clarke, A. J., Slater, N. J., Salmon, J. M., Jackson, S. P. et al. (2006). A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood 108, 2248-2256.
69. Mead, P. E., Deconinck, A. E., Huber, T. L., Orkin, S. H. and Zon, L. I. (2001). Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development 128, 2301-2308.
70. Meier, N., Krpic, S., Rodriguez, P., Strouboulis, J., Monti, M., Krijgsveld, J., Gering, M., Patient, R., Hostert, A. and Grosveld, F. (2006). Novel binding partners of Ldb1 are required for haematopoietic development. Development 133, 4913-4923.
71. Miccio, A. and Blobel, G. A. (2010). Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol. Cell. Biol. 30, 3460-3470.
72. Miccio, A., Wang, Y., Hong, W., Gregory, G. D., Wang, H., Yu, X., Choi, J. K., Shelat, S., Tong, W., Poncz, M. et al. (2010). NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 29, 442-456.
73. Migliaccio, A. R., Rana, R. A., Sanchez, M., Lorenzini, R., Centurione, L., Bianchi, L., Vannucchi, A. M., Migliaccio, G. and Orkin, S. H. (2003). GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J. Exp. Med. 197, 281-296.
74. Mikkola, H. K. A., Klintman, J., Yang, H., Hock, H., Schlaeger, T. M., Fujiwara, Y. and Orkin, S. H. (2003). Haematopoietic stem cells retain longterm repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421, 547-551.
75. Mimoto, M. S. and Christian, J. L. (2012). Friend of GATA (FOG) interacts with the nucleosome remodeling and deacetylase complex (NuRD) to support primitive erythropoiesis in Xenopus laevis. PLoS ONE 7, e29882.
76. Molkentin, J. D. (2000). The zinc finger-containing transcription factors GATA-4,-5, and-6. Ubiquitously expressed regulators of tissue-specific gene expression. J. Biol. Chem. 275, 38949-38952.
77. Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N. (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11, 1061-1072.
78. Morrisey, E. E., Ip, H. S., Tang, Z. and Parmacek, M. S. (1997). GATA-4 activates transcription via two novel domains that are conserved within the GATA-4/5/6 subfamily. J. Biol. Chem. 272, 8515-8524.
79. Nardelli, J., Thiesson, D., Fujiwara, Y., Tsai, F.-Y. and Orkin, S. H. (1999). Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev. Biol. 210, 305-321.
80. Nichols, K. E., Crispino, J. D., Poncz, M., White, J. G., Orkin, S. H., Maris, J. M. and Weiss, M. J. (2000). Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat. Genet. 24, 266-270.
81. Oka, T., Maillet, M., Watt, A. J., Schwartz, R. J., Aronow, B. J., Duncan, S. A. and Molkentin, J. D. (2006). Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ. Res. 98, 837-845.
82. Pal, S., Cantor, A. B., Johnson, K. D., Moran, T. B., Boyer, M. E., Orkin, S. H. and Bresnick, E. H. (2004). Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc. Natl. Acad. Sci. USA 101, 980-985.
83. Pang, L., Xue, H.-H., Szalai, G., Wang, X., Wang, Y., Watson, D. K., Leonard, W. J., Blobel, G. A. and Poncz, M. (2006). Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood 108, 2198-2206.
84. Patient, R. K. and McGhee, J. D. (2002). The GATA family (vertebrates and invertebrates). Curr. Opin. Genet. Dev. 12, 416-422.
85. Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S. F., D'Agati, V., Orkin, S. H. and Costantini, F. (1991). Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349, 257-260.
86. Querfurth, E., Schuster, M., Kulessa, H., Crispino, J. D., Döderlein, G., Orkin, S. H., Graf, T. and Nerlov, C. (2000). Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Genes Dev. 14, 2515-2525.
87. Raich, N., Clegg, C. H., Grofti, J., Roméo, P. H. and Stamatoyannopoulos, G. (1995). GATA1 and YY1 are developmental repressors of the human epsilonglobin gene. EMBO J. 14, 801-809.
88. Ramain, P., Heitzler, P., Haenlin, M. and Simpson, P. (1993). pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. Development 119, 1277-1291.
89. Rehorn, K. P., Thelen, H., Michelson, A. M. and Reuter, R. (1996). A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila. Development 122, 4023-4031.
90. Rivera-Feliciano, J., Lee, K.-H., Kong, S. W., Rajagopal, S., Ma, Q., Springer, Z., Izumo, S., Tabin, C. J. and Pu, W. T. (2006). Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133, 3607-3618.
91. Roche, A. E., Bassett, B. J., Samant, S. A., Hong, W., Blobel, G. A. and Svensson, E. C. (2008). The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex. J. Mol. Cell. Cardiol. 44, 352-360.
92. Rodriguez, P., Bonte, E., Krijgsveld, J., Kolodziej, K. E., Guyot, B., Heck, A. J. R., Vyas, P., de Boer, E., Grosveld, F. and Strouboulis, J. (2005). GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 24, 2354-2366.
93. Rylski, M., Welch, J. J., Chen, Y.-Y., Letting, D. L., Diehl, J. A., Chodosh, L. A., Blobel, G. A. and Weiss, M. J. (2003). GATA-1-mediated proliferation arrest during erythroid maturation. Mol. Cell. Biol. 23, 5031-5042.
94. Salmon, J. M., Slater, N. J., Hall, M. A., McCormack, M. P., Nutt, S. L., Jane, S. M. and Curtis, D. J. (2007). Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood 110, 3573-3581.
95. Schuh, A. H., Tipping, A. J., Clark, A. J., Hamlett, I., Guyot, B., Iborra, F. J., Rodriguez, P., Strouboulis, J., Enver, T., Vyas, P. et al. (2005). ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol. Cell. Biol. 25, 10235-10250.
96. Sorrentino, R. P., Tokusumi, T. and Schulz, R. A. (2007). The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila. Dev. Biol. 311, 311-323.
97. Svensson, E. C., Tufts, R. L., Polk, C. E. and Leiden, J. M. (1999). Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc. Natl. Acad. Sci. USA 96, 956-961.
98. Svensson, E. C., Huggins, G. S., Dardik, F. B., Polk, C. E. and Leiden, J. M. (2000a). A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription. J. Biol. Chem. 275, 20762-20769.
99. Svensson, E. C., Huggins, G. S., Lin, H., Clendenin, C., Jiang, F., Tufts, R., Dardik, F. B. and Leiden, J. M. (2000b). A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat. Genet. 25, 353-356.
100. Talbot, D., Philipsen, S., Fraser, P. and Grosveld, F. (1990). Detailed analysis of the site 3 region of the human beta-globin dominant control region. EMBO J. 9, 2169-2177.
101. Tevosian, S. G., Deconinck, A. E., Cantor, A. B., Rieff, H. I., Fujiwara, Y., Corfas, G. and Orkin, S. H. (1999). FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc. Natl. Acad. Sci. USA 96, 950-955.
102. Tevosian, S. G., Deconinck, A. E., Tanaka, M., Schinke, M., Litovsky, S. H., Izumo, S., Fujiwara, Y. and Orkin, S. H. (2000). FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell 101, 729-739.
103. Tevosian, S. G., Albrecht, K. H., Crispino, J. D., Fujiwara, Y., Eicher, E. M. and Orkin, S. H. (2002). Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development 129, 4627-4634.
104. Tijssen, M. R., Cvejic, A., Joshi, A., Hannah, R. L., Ferreira, R., Forrai, A., Bellissimo, D. C., Oram, S. H., Smethurst, P. A., Wilson, N. K. et al. (2011). Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev. Cell 20, 597-609.
105. Ting, C.-N., Olson, M. C., Barton, K. P. and Leiden, J. M. (1996). Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384, 474-478.
106. Tong, J. K., Hassig, C. A., Schnitzler, G. R., Kingston, R. E. and Schreiber, S. L. (1998). Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 395, 917-921.
107. Trainor, C. D., Omichinski, J. G., Vandergon, T. L., Gronenborn, A. M., Clore, G. M. and Felsenfeld, G. (1996). A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNAbinding domain for high-affinity interaction. Mol. Cell. Biol. 16, 2238-2247.
108. Tripic, T., Deng, W., Cheng, Y., Zhang, Y., Vakoc, C. R., Gregory, G. D., Hardison, R. C. and Blobel, G. A. (2009). SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 113, 2191-2201.
109. Tsai, F.-Y. and Orkin, S. H. (1997). Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89, 3636-3643.
110. Tsai, F.-Y., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W. and Orkin, S. H. (1994). An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371, 221-226.
111. Tsai, S. F., Martin, D. I., Zon, L. I., D'Andrea, A. D., Wong, G. G. and Orkin, S. H. (1989). Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature 339, 446-451.
112. Tsang, A. P., Visvader, J. E., Turner, C. A., Fujiwara, Y., Yu, C., Weiss, M. J., Crossley, M. and Orkin, S. H. (1997). FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 90, 109-119.
113. Tsang, A. P., Fujiwara, Y., Hom, D. B. and Orkin, S. H. (1998). Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 12, 1176-1188.
114. Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J. and Blobel, G. A. (2005). Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol. Cell 17, 453-462.
115. Wade, P. A., Jones, P. L., Vermaak, D. and Wolffe, A. P. (1998). A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase. Curr. Biol. 8, 843-848.
116. Wadman, I. A., Osada, H., Grütz, G. G., Agulnick, A. D., Westphal, H., Forster, A. and Rabbitts, T. H. (1997). The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16, 3145-3157.
117. Walton, R. Z., Bruce, A. E. E., Olivey, H. E., Najib, K., Johnson, V., Earley, J. U., Ho, R. K. and Svensson, E. C. (2006). Fog1 is required for cardiac looping in zebrafish. Dev. Biol. 289, 482-493.
118. Waltzer, L., Bataillé, L., Peyrefitte, S. and Haenlin, M. (2002). Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis. EMBO J. 21, 5477-5486.
119. Wang, X., Crispino, J. D., Letting, D. L., Nakazawa, M., Poncz, M. and Blobel, G. A. (2002). Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. EMBO J. 21, 5225-5234.
120. Weiss, M. J. and Orkin, S. H. (1995). GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol. 23, 99-107.
121. Weiss, M. J., Keller, G. and Orkin, S. H. (1994). Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 8, 1184-1197.
122. Weiss, M. J., Yu, C. and Orkin, S. H. (1997). Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol. Cell. Biol. 17, 1642-1651.
123. Wilkinson-White, L., Gamsjaeger, R., Dastmalchi, S., Wienert, B., Stokes, P. H., Crossley, M., Mackay, J. P. and Matthews, J. M. (2011). Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1. Proc. Natl. Acad. Sci. USA 108, 14443-14448.
124. Wu, W., Cheng, Y., Keller, C. A., Ernst, J., Kumar, S. A., Mishra, T., Morrissey, C., Dorman, C. M., Chen, K.-B., Drautz, D. et al. (2011). Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res. 21, 1659-1671.
125. Yamamoto, M., Ko, L. J., Leonard, M. W., Beug, H., Orkin, S. H. and Engel, J. D. (1990). Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 4, 1650-1662.
126. Yang, H. Y. and Evans, T. (1992). Distinct roles for the two cGATA-1 finger domains. Mol. Cell. Biol. 12, 4562-4570.
127. Yang, Z., Gu, L., Romeo, P. H., Bories, D., Motohashi, H., Yamamoto, M. and Engel, J. D. (1994). Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains. Mol. Cell. Biol. 14, 2201-2212.
128. Yomogida, K., Ohtani, H., Harigae, H., Ito, E., Nishimune, Y., Engel, J. D. and Yamamoto, M. (1994). Developmental stage-and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development 120, 1759-1766.
129. Yu, C., Cantor, A. B., Yang, H., Browne, C., Wells, R. A., Fujiwara, Y. and Orkin, S. H. (2002). Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J. Exp. Med. 195, 1387-1395.
130. Yu, M., Riva, L., Xie, H., Schindler, Y., Moran, T. B., Cheng, Y., Yu, D., Hardison, R., Weiss, M. J., Orkin, S. H. et al. (2009). Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol. Cell 36, 682-695.
131. Zeisberg, E. M., Ma, Q., Juraszek, A. L., Moses, K., Schwartz, R. J., Izumo, S. and Pu, W. T. (2005). Morphogenesis of the right ventricle requires myocardial expression of Gata4. J. Clin. Invest. 115, 1522-1531.
132. Zhang, Y., LeRoy, G., Seelig, H.-P., Lane, W. S. and Reinberg, D. (1998). The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell 95, 279-289.
133. Zheng, W. and Flavell, R. A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596.
134. Zhou, B., Ma, Q., Kong, S. W., Hu, Y., Campbell, P. H., McGowan, F. X., Ackerman, K. G., Wu, B., Zhou, B., Tevosian, S. G. et al. (2009). Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J. Clin. Invest. 119, 1462-1476.
135. + T cells. J. Exp. Med. 194, 1461-1471.
136. Zon, L. I., Mather, C., Burgess, S., Bolce, M. E., Harland, R. M. and Orkin, S. H. (1991). Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc. Natl. Acad. Sci. USA 88, 10642-10646.
137. Zon, L. I., Yamaguchi, Y., Yee, K., Albee, E. A., Kimura, A., Bennett, J. C., Orkin, S. H. and Ackerman, S. J. (1993). Expression of mRNA for the GATAbinding proteins in human eosinophils and basophils: potential role in gene transcription. Blood 81, 3234-3241.