Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo

Molecular and Cellular Biology

Volumn 22, Issue 9, 2002, Pages 3121-3128

  Katz, Samuel G ^a   Cantor, Alan B ^a   Orkin, Stuart H ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINAL BINDING PROTEIN; ERYTHROPOIETIN; MUTANT PROTEIN; PHENYLHYDRAZINE; PROTEIN FOG 1; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ERYTHROPOIESIS; FERTILITY; IMMUNOPRECIPITATION; IN VIVO STUDY; MEGAKARYOPOIESIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; STRAIN DIFFERENCE; WILD TYPE;

ALCOHOL OXIDOREDUCTASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; CONSERVED SEQUENCE; COS CELLS; DNA-BINDING PROTEINS; ERYTHROCYTES; ERYTHROPOIESIS; ERYTHROPOIETIN; GENETIC VECTORS; HEMATOCRIT; MICE; MICE, KNOCKOUT; MUTATION; NUCLEAR PROTEINS; PHENYLHYDRAZINES; PHOSPHOPROTEINS; PRECIPITIN TESTS; PROTEIN BINDING; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSGENES;

ANIMALIA;

EID: 0036238194     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.9.3121-3128.2002     Document Type: Article

References (37)

1. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
2. A region in the C-terminus of adenovirus 2/5 Ela protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
3. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation
4. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: The GATA-1:FOG complex
5. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG factors
6. U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila
7. FOG acts as a repressor of red blood cell development in Xenopus
8. The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila
9. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
10. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
11. Transcriptional activity of Pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila
12. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling
13. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3
14. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
15. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
16. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut
17. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
18. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
19. Interaction of short-range repressors with Drosophila CtBP in the embryo
20. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA-1
21. GATA-binding transcription factors in hematopoietic cells
22. ZEB represses transcription through interaction with the corepressor CtBP
23. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
24. Interaction between a cellular protein that binds to the c-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif
25. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
26. Effects of recombinant human erythropoietin on the antitumor effect of cisplatin I SCID mice bearing human ovarian cancer: A possible oxygen effect
27. The CtBP binding domain in the adenovirus EIA protein controls CR1-dependent transactivation
28. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex
29. FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped
30. FOG-2, a cofactor of GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium
31. Failure of megakaryocytopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcription factor cofactor FOG
32. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
33. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
34. The CtBP family: Enigmatic and enzymatic transcriptional co-repressors
35. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice
36. The C-terminal (BRCT) domains of BRCAI interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
37. Association of COOH-terminal-binding protein (CtBP) and MEF2- interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor