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Volumn 210, Issue , 2012, Pages 369-394

Novel targets for platelet inhibition

Author keywords

Antiplatelet drugs; Functional genomics; Genome wide association studies; Inherited bleeding disorder; Proteomics

Indexed keywords

ACTIN BINDING PROTEIN; ALDEHYDE REDUCTASE; CD39 ANTIGEN; ECTO NUCLEOTIDASE; FIBRINOGEN RECEPTOR; GLYCOPROTEIN VI; GREEN FLUORESCENT PROTEIN; GROWTH ARREST SPECIFIC PROTEIN 6; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; IMMUNOGLOBULIN RECEPTOR; IMMUNOGLOBULIN RECEPTOR G6B; LEPTIN; LEPTIN RECEPTOR; NUCLEOTIDASE; PROTEIN DISULFIDE ISOMERASE; PROTEIN ERP57; PROTEIN GS ALPHA; PROTEIN HIP 55; RGS2 PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; THROMBOCYTE RECEPTOR; TYROSINE KINASE RECEPTOR; TYROSINE KINASE RECEPTOR 3; TYROSINE KINASE RECEPTOR AXL; TYROSINE KINASE RECEPTOR MER; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; CYCLIC AMP;

EID: 84867168448     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-29423-5_15     Document Type: Article
Times cited : (9)

References (85)
  • 5
    • 0027384993 scopus 로고
    • Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38 across the blood-brain barrier
    • Banks WA, Kastin AJ, Komaki G, Arimura A (1993) Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38 across the blood-brain barrier. J Pharmacol Exp Ther 267:690-696
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 690-696
    • Banks, W.A.1    Kastin, A.J.2    Komaki, G.3    Arimura, A.4
  • 6
    • 0035082563 scopus 로고    scopus 로고
    • Platelet function inhibitors in the year 2000
    • Bennett JS, Mousa S (2001) Platelet function inhibitors in the year 2000. Thromb Haemost 85:395-400
    • (2001) Thromb Haemost , vol.85 , pp. 395-400
    • Bennett, J.S.1    Mousa, S.2
  • 7
    • 0035120357 scopus 로고    scopus 로고
    • Novel platelet inhibitors
    • Bennett JS (2001) Novel platelet inhibitors. Annu Rev Med 52:161-184
    • (2001) Annu Rev Med , vol.52 , pp. 161-184
    • Bennett, J.S.1
  • 9
    • 4444269330 scopus 로고    scopus 로고
    • Impaired Platelet Responses to Thrombin and Collagen in AKT-1-deficient Mice
    • Chen J, De S, Damron DS, Chen WS, Hay N, Byzova TV (2004) Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood 104:1703-1710
    • (2004) Blood , vol.104 , pp. 1703-1710
    • Chen, J.1    De S Damron, D.S.2    Chen, W.S.3    Hay, N.4    Byzova, T.V.5
  • 17
    • 34548763149 scopus 로고    scopus 로고
    • Recent advances in the characterisation of the platelet membrane system by proteomics
    • Foy M, Maguire PB (2007) Recent advances in the characterisation of the platelet membrane system by proteomics. Curr Pharm Des 13:2647-2655
    • (2007) Curr Pharm des , vol.13 , pp. 2647-2655
    • Foy, M.1    Maguire, P.B.2
  • 18
    • 0034840142 scopus 로고    scopus 로고
    • Genetic variation of the extra-large stimulatory G protein alpha-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding
    • Freson K, Hoylaerts MF, Jaeken J, Eyssen M, Arnout J, Vermylen J, Van Geet C (2001) Genetic variation of the extra-large stimulatory G protein alpha-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding. Thromb Haemost 86:733-738
    • (2001) Thromb Haemost , vol.86 , pp. 733-738
    • Freson, K.1    Hoylaerts, M.F.2    Jaeken, J.3    Eyssen, M.4    Arnout, J.5    Vermylen, J.6    Van Geet, C.7
  • 19
    • 0038778398 scopus 로고    scopus 로고
    • Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptormediated cAMP formation
    • Freson K, Jaeken J, Van Helvoirt M, de Zegher F, Wittevrongel C, Thys C, Hoylaerts MF, Vermylen J, Van Geet C (2003) Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptormediated cAMP formation. Hum Mol Genet 12:1121-1130
    • (2003) Hum Mol Genet , vol.12 , pp. 1121-1130
    • Freson, K.1    Jaeken, J.2    Van Helvoirt, M.3    De Zegher, F.4    Wittevrongel, C.5    Thys, C.6    Hoylaerts, M.F.7    Vermylen, J.8    Van Geet, C.9
  • 21
    • 57349170190 scopus 로고    scopus 로고
    • Compound heterozygous mutations in the GNAS gene of a boy with morbid obesity, thyroid-stimulating hormone resistance, pseudohypoparathyroidism, and a prothrombotic state
    • Freson K, Izzi B, Jaeken J, Van Helvoirt M, Thys C, Wittevrongel C, de Zegher F, Van Geet C (2008) Compound heterozygous mutations in the GNAS gene of a boy with morbid obesity, thyroid-stimulating hormone resistance, pseudohypoparathyroidism, and a prothrombotic state. J Clin Endocrinol Metab 93:4844-4849
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4844-4849
    • Freson, K.1    Izzi, B.2    Jaeken, J.3    Van Helvoirt, M.4    Thys, C.5    Wittevrongel, C.6    De Zegher, F.7    Van Geet, C.8
  • 22
    • 26844452187 scopus 로고    scopus 로고
    • The platelet microparticle proteome
    • Garcia BA, Smalley DM, Cho H et al (2005) The platelet microparticle proteome. J Proteome Res 4:1516-1521
    • (2005) J Proteome Res , vol.4 , pp. 1516-1521
    • Garcia, B.A.1    Smalley, D.M.2    Cho, H.3
  • 25
    • 70349254628 scopus 로고    scopus 로고
    • Endobrevin/VAMP- 8-dependent dense granule release mediates thrombus formation in vivo
    • Graham GJ, Ren Q, Dilks JR, Blair P, Whiteheart SW, Flaumenhaft R (2009) Endobrevin/VAMP- 8-dependent dense granule release mediates thrombus formation in vivo. Blood 114:1083-1090
    • (2009) Blood , vol.114 , pp. 1083-1090
    • Graham, G.J.1    Ren, Q.2    Dilks, J.R.3    Blair, P.4    Whiteheart, S.W.5    Flaumenhaft, R.6
  • 26
    • 0347362831 scopus 로고    scopus 로고
    • The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling
    • Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH (2003) The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling. J Biol Chem 278:52195-52202
    • (2003) J Biol Chem , vol.278 , pp. 52195-52202
    • Han, J.1    Kori, R.2    Shui, J.W.3    Chen, Y.R.4    Yao, Z.5    Tan, T.H.6
  • 27
    • 77949279691 scopus 로고    scopus 로고
    • Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation
    • Harper MT, Poole AW (2010) Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. J Thromb Haemost 8:454-462
    • (2010) J Thromb Haemost , vol.8 , pp. 454-462
    • Harper, M.T.1    Poole, A.W.2
  • 34
    • 0035179087 scopus 로고    scopus 로고
    • Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
    • Konstantinides S, Schäfer K, Koschnick S, Loskutoff DJ (2001) Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108:1533-1540
    • (2001) J Clin Invest , vol.108 , pp. 1533-1540
    • Konstantinides, S.1    Schäfer, K.2    Koschnick, S.3    Loskutoff, D.J.4
  • 35
    • 76249134542 scopus 로고    scopus 로고
    • The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation
    • Kunert S, Meyer I, Fleischhauer S, Wannack M, Fiedler J, Shivdasani RA, Schulze H (2009) The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood 114:5532-5540
    • (2009) Blood , vol.114 , pp. 5532-5540
    • Kunert, S.1    Meyer, I.2    Fleischhauer, S.3    Wannack, M.4    Fiedler, J.5    Shivdasani, R.A.6    Schulze, H.7
  • 37
    • 33646338630 scopus 로고    scopus 로고
    • Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome database
    • Li W, He M, Zhou H, Bourne JW, Liang P (2006) Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome database. Hum Mutat 27:402-407
    • (2006) Hum Mutat , vol.27 , pp. 402-407
    • Li, W.1    He, M.2    Zhou, H.3    Bourne, J.W.4    Liang, P.5
  • 39
    • 33947216911 scopus 로고    scopus 로고
    • The active platelet: Translation and protein synthesis in an anucleate cell
    • Lindemann S, Gawaz M (2007) The active platelet: translation and protein synthesis in an anucleate cell. Semin Thromb Hemost 33:144-150
    • (2007) Semin Thromb Hemost , vol.33 , pp. 144-150
    • Lindemann, S.1    Gawaz, M.2
  • 41
    • 0033847019 scopus 로고    scopus 로고
    • Identification of platelet proteins separated by two-dimensional gel electrophoresis and analyzed by matrix assisted laser desorption/ ionization-time of flight-mass spectrometry and detection of tyrosine-phosphorylated proteins
    • Marcus K, Immler D, Sternberger J, Meyer HE (2000) Identification of platelet proteins separated by two-dimensional gel electrophoresis and analyzed by matrix assisted laser desorption/ ionization-time of flight-mass spectrometry and detection of tyrosine-phosphorylated proteins. Electrophoresis 21:2622-2636
    • (2000) Electrophoresis , vol.21 , pp. 2622-2636
    • Marcus, K.1    Immler, D.2    Sternberger, J.3    Meyer, H.E.4
  • 42
    • 0037381237 scopus 로고    scopus 로고
    • Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: Implications for ischemic vascular diseases
    • Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Pinsky DJ, Sesti C, Levi R (2003) Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. J Pharmacol Exp Ther 305:9-16
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 9-16
    • Marcus, A.J.1    Broekman, M.J.2    Drosopoulos, J.H.3    Islam, N.4    Pinsky, D.J.5    Sesti, C.6    Levi, R.7
  • 45
    • 77958539006 scopus 로고    scopus 로고
    • The a-granule proteome: Novel proteins in normal and ghost granules in gray platelet syndrome
    • Maynard DM, Heijnen HF, Gahl WA, Gunay-Aygun M (2010) The a-granule proteome: novel proteins in normal and ghost granules in gray platelet syndrome. J Thromb Haemost 8:1786-1796
    • (2010) J Thromb Haemost , vol.8 , pp. 1786-1796
    • Maynard, D.M.1    Heijnen, H.F.2    Gahl, W.A.3    Gunay-Aygun, M.4
  • 51
    • 70449431471 scopus 로고    scopus 로고
    • CIB1 deficiency results in impaired thrombosis: The potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3
    • Naik MU, Nigam A, Manrai P, Millili P, Czymmek K, Sullivan M, Naik UP (2009) CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3. J Thromb Haemost 7:1906-1914
    • (2009) J Thromb Haemost , vol.7 , pp. 1906-1914
    • Naik, M.U.1    Nigam, A.2    Manrai, P.3    Millili, P.4    Czymmek, K.5    Sullivan, M.6    Naik, U.P.7
  • 52
    • 21644458951 scopus 로고    scopus 로고
    • Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation
    • Nanda N, Bao M, Lin H, Clauser K, Komuves L, Quertermous T, Conley PB, Phillips DR, Hart MJ (2005) Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem 280:24680-24689
    • (2005) J Biol Chem , vol.280 , pp. 24680-24689
    • Nanda, N.1    Bao, M.2    Lin, H.3    Clauser, K.4    Komuves, L.5    Quertermous, T.6    Conley, P.B.7    Phillips, D.R.8    Hart, M.J.9
  • 55
    • 77955646166 scopus 로고    scopus 로고
    • Regulators of platelet cAMP levels: Clinical and therapeutic implications
    • Noé L, Peeters K, Izzi B, Van Geet C, Freson K (2010b) Regulators of platelet cAMP levels: clinical and therapeutic implications. Curr Med Chem 17:2897-2905
    • (2010) Curr Med Chem , vol.17 , pp. 2897-2905
    • Noé, L.1    Peeters, K.2    Izzi, B.3    Van Geet, C.4    Freson, K.5
  • 58
    • 30644474035 scopus 로고    scopus 로고
    • Agonists-induced platelet activation varies considerably in healthy male individuals: Studies by flow cytometry
    • Panzer S, Höcker L, Koren D (2006) Agonists-induced platelet activation varies considerably in healthy male individuals: studies by flow cytometry. Ann Hematol 85:121-125
    • (2006) Ann Hematol , vol.85 , pp. 121-125
    • Panzer, S.1    Höcker, L.2    Koren, D.3
  • 60
    • 0029953824 scopus 로고    scopus 로고
    • Characterization of vasoactive intestinal peptide receptors on human megakaryocytes and platelets
    • Park SK, Olson TA, Ercal N, Summers M, O'Dorisio MS (1996) Characterization of vasoactive intestinal peptide receptors on human megakaryocytes and platelets. Blood 87:4629-4635
    • (1996) Blood , vol.87 , pp. 4629-4635
    • Park, S.K.1    Olson, T.A.2    Ercal, N.3    Summers, M.4    O'Dorisio, M.S.5
  • 64
    • 33745967215 scopus 로고    scopus 로고
    • Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor
    • Pozgajová M, Sachs UJ, Hein L, Nieswandt B (2006) Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor. Blood 108:510-514
    • (2006) Blood , vol.108 , pp. 510-514
    • Pozgajová, M.1    Sachs, U.J.2    Hein, L.3    Nieswandt, B.4
  • 68
    • 53549126624 scopus 로고    scopus 로고
    • Modifications by Olmesartan medoxomil treatment of the platelet protein profile of moderate hypertensive patients
    • Sacristan D, Marques M, Zamorano J et al (2008) Modifications by Olmesartan medoxomil treatment of the platelet protein profile of moderate hypertensive patients. Proteomics Clin Appl 2:1300-1312
    • (2008) Proteomics Clin Appl , vol.2 , pp. 1300-1312
    • Sacristan, D.1    Marques, M.2    Zamorano, J.3
  • 71
    • 70350015034 scopus 로고    scopus 로고
    • Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions
    • Senis YA, Antrobus R, Severin S, Parguina AF, Rosa I, Zitzmann N, Watson SP, García A (2009a) Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. J Thromb Haemost 7:1718-1726
    • (2009) J Thromb Haemost , vol.7 , pp. 1718-1726
    • Senis, Y.A.1    Antrobus, R.2    Severin, S.3    Parguina, A.F.4    Rosa, I.5    Zitzmann, N.6    Watson, S.P.7    García, A.8
  • 73
    • 76549094772 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases
    • Siller-Matula JM, Krumphuber J, Jilma B (2010) Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases. Br J Pharmacol 159:502-517
    • (2010) Br J Pharmacol , vol.159 , pp. 502-517
    • Siller-Matula, J.M.1    Krumphuber, J.2    Jilma, B.3
  • 77
    • 0033565782 scopus 로고    scopus 로고
    • Identification of pituitary adenylate cyclaseactivating polypeptide1-38-binding factor in human plasma, as ceruloplasmin
    • Tams JW, Johnsen AH, Fahrenkrug J (1999) Identification of pituitary adenylate cyclaseactivating polypeptide1-38-binding factor in human plasma, as ceruloplasmin. Biochem J 341:271-276
    • (1999) Biochem J , vol.341 , pp. 271-276
    • Tams, J.W.1    Johnsen, A.H.2    Fahrenkrug, J.3
  • 80
    • 70349125020 scopus 로고    scopus 로고
    • Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets
    • Tucker KL, Kaiser WJ, Bergeron AL, Hu H, Dong JF, Tan TH, Gibbins JM (2009) Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics 9:4340-4354
    • (2009) Proteomics , vol.9 , pp. 4340-4354
    • Tucker, K.L.1    Kaiser, W.J.2    Bergeron, A.L.3    Hu, H.4    Dong, J.F.5    Tan, T.H.6    Gibbins, J.M.7
  • 83
    • 27144453722 scopus 로고    scopus 로고
    • Aggregometry detects platelet hyperreactivity in healthy individuals
    • Yee DL, Sun CW, Bergeron AL, Dong JF, Bray PF (2005) Aggregometry detects platelet hyperreactivity in healthy individuals. Blood 106:2723-2729
    • (2005) Blood , vol.106 , pp. 2723-2729
    • Yee, D.L.1    Sun, C.W.2    Bergeron, A.L.3    Dong, J.F.4    Bray, P.F.5
  • 84


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