Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation

Journal of Biological Chemistry

Volumn 280, Issue 26, 2005, Pages 24680-24689

  Nanda, Nisha ^a,c   Bao, Ming ^c   Lin, Hanna ^c   Clauser, Karl ^c   Komuves, Laszlo ^c   Quertermous, Thomas ^a   Conley, Pamela B ^b,c   Phillips, David R ^b,c   Hart, Matthew J ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Portola Pharmaceuticals Inc   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOCHEMISTRY; CYTOLOGY; ENZYME INHIBITION; PROTEINS;

EPIDERMAL GROWTH; MICROARRAYS; PLATELET AGGREGATION; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1 (PEAR1);

CELL MEMBRANES;

ADAPTOR PROTEIN; EPIDERMAL GROWTH FACTOR; EPTIFIBATIDE; MEMBRANE RECEPTOR; PROTEIN PEAR1; PROTEIN SHC; PROTEIN SHCB; SERINE; THREONINE; THROMBOCYTE RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CENTRIFUGATION; DNA MICROARRAY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEOMICS; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

AMINO ACID SEQUENCE; ANIMALS; BIOTIN; BLOOD PLATELETS; BLOTTING, WESTERN; CELL COMMUNICATION; CELL LINE; CLONING, MOLECULAR; COS CELLS; CROSS-LINKING REAGENTS; CYTOPLASM; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIAL CELLS; EPIDERMAL GROWTH FACTOR; FLOW CYTOMETRY; HUMANS; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; PEROXIDASE; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SIGNAL TRANSDUCTION; THREONINE; TISSUE DISTRIBUTION; TRANSFECTION; TYROSINE;

EID: 21644458951     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413411200     Document Type: Article

References (27)

1. Law, D. A., DeGuzman, F. R., Heiser, P., Ministri-Madrid, K., Killeen, N., and Phillips, D. R. (1999) Nature 401, 808-811
2. Andre, P., Prasad, K. S., Denis, C. V., He, M., Papalia, J. M., Hynes, R. O., Phillips, D. R., and Wagner, D. D. (2002) Nat. Med. 8, 247-252
3. Angelillo-Scherrer, A., de Frutos, P., Aparicio, C., Melis, E., Savi, P., Lupu, F., Arnout, J., Dewerchin, M., Hoylaerts, M., Herbert, J., Collen, D., Dahlback, B., and Carmeliet, P. (2001) Nat. Med. 7, 215-221
4. Prevost, N., Woulfe, D., Tanaka, T., and Brass, L. F. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 9219-9224
5. Prevost, N., Woulfe, D., Tognolini, M., and Brass, L. F. (2003) J. Thromb. Haemost. 1, 1613-1627
6. Komuves, L. G., Feren, A., Jones, A. L., and Fodor, E. (2000) J. Histochem. Cytochem. 48, 821-830
7. Wasserman, S. M., Mehraban, F., Komuves, L. G., Yang, R. B., Tomlinson, J. E., Zhang, Y., Spriggs, F., and Topper, J. N. (2002) Physiol. Genomics 12, 13-23
8. Cowan, K. J., Law, D. A., and Phillips, D. R. (2000) J. Biol. Chem. 275, 36423-36429
9. Loyet, K. M., Stults, J. T., and Arnott, D. (2005) Mol. Cell. Proteomics 4, 235-245
10. Jantzen, H. M., Gousset, L., Bhaskar, V., Vincent, D., Tai, A., Reynolds, E. E., and Conley, P. B. (1999) Thromb. Haemost. 81, 111-117
11. Apweiler, R., Attwood, T. K., Bairoch, A., Bateman, A., Birney, E., Biswas, M., Bucher, P., Cerutti, L., Corpet, F., Croning, M. D., Durbin, R., Falquet, L., Fleischmann, W., Gouzy, J., Hermjakob, H., Hulo, N., Jonassen, I., Kahn, D., Kanapin, A., Karavidopoulou, Y., Lopez, R., Marx, B., Mulder, N. J., Oinn, T. M., Pagni, M., Servant, F., Sigrist, C. J., and Zdobnov, E. M. (2001) Nucleic Acids Res. 29, 37-40
12. Zhou, Z., Hartwieg, E., and Horvitz, H. R. (2001) Cell 104, 43-56
13. Adachi, H., Tsujimoto, M., Arai, H., and Inoue, K (1997) J. Biol. Chem. 272, 31217-31220
14. Obenauer, J. C., Cantley, L. C., and Yaffe, M. B. (2003) Nucleic Acids Res. 31, 3635-3641
15. Barnes, H., Larsen, B., Tyers, M., and van Der Geer, P. (2001) J. Biol. Chem. 276, 19119-19125
16. Bork, P., Downing, A. K., Kieffer, B., and Campbell, I. D. (1996) Q. Rev. Biophys. 29, 119-167
17. Phillips, D. R., and Scarborough, R. M. (1997) Am. J. Cardiol. 80, 11B-20B.
18. Law, D. A., Nannizzi-Alaimo, L., and Phillips, D. R. (1996) J. Biol. Chem. 271, 10811-10815
19. Li, R., Bennett, J. S., and Degrado, W. F. (2004) Biochem. Soc. Trans. 32, 412-415
20. Schlessinger, J. (2002) Cell 110, 669-672
21. Ferguson, K. M., Darling, P. J., Mohan, M. J., Macatee, T. L., and Lemmon, M. A. (2000) EMBO J. 19, 4632-4643
22. Klein, P., Mattoon, D., Lemmon, M. A., and Schlessinger, J. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 929-934
23. Ishii, J., Adachi, H., Aoki, J., Koizumi, H., Tomita, S., Suzuki, T., Tsujimoto, M., Inoue, K., and Arai, H. (2002) J. Biol. Chem. 277, 39696-39702
24. Phillips, D. R., Prasad, K. S., Manganello, J., Bao, M., and Nannizzi-Alaimo, L. (2001) Curr. Opin. Cell Biol. 13, 546-554
25. Arias-Salgado, E. G., Lizano, S., Sarkar, S., Brugge, J. S., Ginsberg, M. H., and Shattil, S. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 13298-13302
26. Migliaccio, E., Mele, S., Salcini, A. E., Pelicci, G., Lai, K. M., Superti-Furga, G., Pawson, T., Di Fiore, P. P., Lanfrancone, L., and Pelicci, P. G. (1997) EMBO J. 16, 706-716
27. Wheelock, M. J., and Johnson, K. R. (2003) Annu. Rev. Cell Dev. Biol. 19, 207-235