-
1
-
-
63049090100
-
Metastasis: from dissemination to organ-specific colonization
-
Nguyen DX, Bos PD, Massague J, (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 274-284
-
-
Nguyen, D.X.1
Bos, P.D.2
Massague, J.3
-
2
-
-
0038481970
-
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
-
Fidler IJ, (2003) The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453-458.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 453-458
-
-
Fidler, I.J.1
-
3
-
-
80054686286
-
Tumor metastasis: molecular insights and evolving paradigms
-
Valastyan S, Weinberg RA, (2011) Tumor metastasis: molecular insights and evolving paradigms. Cell 147: 275-292.
-
(2011)
Cell
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
4
-
-
81255205399
-
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
-
Labelle M, Begum S, Hynes RO, (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20: 576-590.
-
(2011)
Cancer Cell
, vol.20
, pp. 576-590
-
-
Labelle, M.1
Begum, S.2
Hynes, R.O.3
-
5
-
-
42549167207
-
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
-
Pawelek JM, Chakraborty AK, (2008) Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. Nat Rev Cancer 8: 377-386.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 377-386
-
-
Pawelek, J.M.1
Chakraborty, A.K.2
-
6
-
-
63049121364
-
The metastatic niche: adapting the foreign soil
-
Psaila B, Lyden D, (2009) The metastatic niche: adapting the foreign soil. Nat Rev Cancer 9: 285-293.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 285-293
-
-
Psaila, B.1
Lyden, D.2
-
7
-
-
78650739435
-
Malignant cells facilitate lung metastasis by bringing their own soil
-
Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, et al. (2010) Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci U S A 107: 21677-21682.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 21677-21682
-
-
Duda, D.G.1
Duyverman, A.M.2
Kohno, M.3
Snuderl, M.4
Steller, E.J.5
-
8
-
-
72249093615
-
Tumor self-seeding by circulating cancer cells
-
Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, et al. (2009) Tumor self-seeding by circulating cancer cells. Cell 139: 1315-1326.
-
(2009)
Cell
, vol.139
, pp. 1315-1326
-
-
Kim, M.Y.1
Oskarsson, T.2
Acharyya, S.3
Nguyen, D.X.4
Zhang, X.H.5
-
9
-
-
56749176437
-
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
-
Jeanes A, Gottardi CJ, Yap AS, (2008) Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 27: 6920-6929.
-
(2008)
Oncogene
, vol.27
, pp. 6920-6929
-
-
Jeanes, A.1
Gottardi, C.J.2
Yap, A.S.3
-
10
-
-
72949119124
-
Integrins in cancer: biological implications and therapeutic opportunities
-
Desgrosellier JS, Cheresh DA, (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10: 9-22.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 9-22
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
11
-
-
65349132693
-
EMT, the cytoskeleton, and cancer cell invasion
-
Yilmaz M, Christofori G, (2009) EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 28: 15-33.
-
(2009)
Cancer Metastasis Rev
, vol.28
, pp. 15-33
-
-
Yilmaz, M.1
Christofori, G.2
-
12
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo W, Giancotti FG, (2004) Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5: 816-826.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 816-826
-
-
Guo, W.1
Giancotti, F.G.2
-
13
-
-
27644470059
-
β1 integrin function in vivo: adhesion, migration and more
-
Brakebusch C, Fassler R, (2005) β1 integrin function in vivo: adhesion, migration and more. Cancer Metastasis Rev 24: 403-411.
-
(2005)
Cancer Metastasis Rev
, vol.24
, pp. 403-411
-
-
Brakebusch, C.1
Fassler, R.2
-
14
-
-
70349754433
-
Integrin α2 mediates selective metastasis to the liver
-
Yoshimura K, Meckel KF, Laird LS, Chia CY, Park JJ, et al. (2009) Integrin α2 mediates selective metastasis to the liver. Cancer Res 69: 7320-7328.
-
(2009)
Cancer Res
, vol.69
, pp. 7320-7328
-
-
Yoshimura, K.1
Meckel, K.F.2
Laird, L.S.3
Chia, C.Y.4
Park, J.J.5
-
15
-
-
0034256088
-
The α3β1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity
-
Morini M, Mottolese M, Ferrari N, Ghiorzo F, Buglioni S, et al. (2000) The α3β1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity. Int J Cancer 87: 336-342.
-
(2000)
Int J Cancer
, vol.87
, pp. 336-342
-
-
Morini, M.1
Mottolese, M.2
Ferrari, N.3
Ghiorzo, F.4
Buglioni, S.5
-
16
-
-
0027157861
-
Integrin expression in cutaneous malignant melanoma: association of the α3β1 heterodimer with tumor progression
-
Natali PG, Nicotra MR, Bartolazzi A, Cavaliere R, Bigotti A, (1993) Integrin expression in cutaneous malignant melanoma: association of the α3β1 heterodimer with tumor progression. Int J Cancer 54: 68-72.
-
(1993)
Int J Cancer
, vol.54
, pp. 68-72
-
-
Natali, P.G.1
Nicotra, M.R.2
Bartolazzi, A.3
Cavaliere, R.4
Bigotti, A.5
-
17
-
-
0028175651
-
Emergence of α5β1 fibronectin- and αVβ3 vitronectin-receptor expression in melanocytic tumour progression
-
Danen EH, Ten Berge PJ, Van Muijen GN, Van't Hof-Grootenboer AE, Brocker EB, et al. (1994) Emergence of α5β1 fibronectin- and αVβ3 vitronectin-receptor expression in melanocytic tumour progression. Histopathology 24: 249-256.
-
(1994)
Histopathology
, vol.24
, pp. 249-256
-
-
Danen, E.H.1
Ten Berge, P.J.2
Van Muijen, G.N.3
Van't Hof-Grootenboer, A.E.4
Brocker, E.B.5
-
18
-
-
0033621689
-
Significance of integrin α5 gene expression as a prognostic factor in node-negative non-small cell lung cancer
-
Adachi M, Taki T, Higashiyama M, Kohno N, Inufusa H, et al. (2000) Significance of integrin α5 gene expression as a prognostic factor in node-negative non-small cell lung cancer. Clin Cancer Res 6: 96-101.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 96-101
-
-
Adachi, M.1
Taki, T.2
Higashiyama, M.3
Kohno, N.4
Inufusa, H.5
-
19
-
-
0030695152
-
The integrin α6β1 promotes the survival of metastatic human breast carcinoma cells in mice
-
Wewer UM, Shaw LM, Albrechtsen R, Mercurio AM, (1997) The integrin α6β1 promotes the survival of metastatic human breast carcinoma cells in mice. Am J Pathol 151: 1191-1198.
-
(1997)
Am J Pathol
, vol.151
, pp. 1191-1198
-
-
Wewer, U.M.1
Shaw, L.M.2
Albrechtsen, R.3
Mercurio, A.M.4
-
21
-
-
67649849871
-
Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
-
Shibue T, Weinberg RA, (2009) Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A 106: 10290-10295.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 10290-10295
-
-
Shibue, T.1
Weinberg, R.A.2
-
22
-
-
77957283664
-
β1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression
-
Huck L, Pontier SM, Zuo DM, Muller WJ, (2010) β1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression. Proc Natl Acad Sci U S A 107: 15559-15564.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 15559-15564
-
-
Huck, L.1
Pontier, S.M.2
Zuo, D.M.3
Muller, W.J.4
-
23
-
-
84855165949
-
Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis
-
Grzesiak JJ, Tran Cao HS, Burton DW, Kaushal S, Vargas F, et al. (2011) Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. Int J Cancer 129: 2905-2915.
-
(2011)
Int J Cancer
, vol.129
, pp. 2905-2915
-
-
Grzesiak, J.J.1
Tran Cao, H.S.2
Burton, D.W.3
Kaushal, S.4
Vargas, F.5
-
24
-
-
33846653542
-
Increased β1 integrin is associated with decreased survival in invasive breast cancer
-
Yao ES, Zhang H, Chen YY, Lee B, Chew K, et al. (2007) Increased β1 integrin is associated with decreased survival in invasive breast cancer. Cancer Res 67: 659-664.
-
(2007)
Cancer Res
, vol.67
, pp. 659-664
-
-
Yao, E.S.1
Zhang, H.2
Chen, Y.Y.3
Lee, B.4
Chew, K.5
-
25
-
-
2942561951
-
High expression of integrin β1 and p53 is a greater poor prognostic factor than clinical stage in small-cell lung cancer
-
Oshita F, Kameda Y, Hamanaka N, Saito H, Yamada K, et al. (2004) High expression of integrin β1 and p53 is a greater poor prognostic factor than clinical stage in small-cell lung cancer. Am J Clin Oncol 27: 215-219.
-
(2004)
Am J Clin Oncol
, vol.27
, pp. 215-219
-
-
Oshita, F.1
Kameda, Y.2
Hamanaka, N.3
Saito, H.4
Yamada, K.5
-
26
-
-
0038798482
-
Immunohistochemical expression of integrins and extracellular matrix proteins in non-small cell lung cancer: correlation with lymph node metastasis
-
Han JY, Kim HS, Lee SH, Park WS, Lee JY, et al. (2003) Immunohistochemical expression of integrins and extracellular matrix proteins in non-small cell lung cancer: correlation with lymph node metastasis. Lung Cancer 41: 65-70.
-
(2003)
Lung Cancer
, vol.41
, pp. 65-70
-
-
Han, J.Y.1
Kim, H.S.2
Lee, S.H.3
Park, W.S.4
Lee, J.Y.5
-
27
-
-
77953548261
-
Integrin expression profiling identifies integrin α5 and β1 as prognostic factors in early stage non-small cell lung cancer
-
Dingemans AM, van den Boogaart V, Vosse BA, van Suylen RJ, Griffioen AW, et al. (2010) Integrin expression profiling identifies integrin α5 and β1 as prognostic factors in early stage non-small cell lung cancer. Mol Cancer 9: 152.
-
(2010)
Mol Cancer
, vol.9
, pp. 152
-
-
Dingemans, A.M.1
van den Boogaart, V.2
Vosse, B.A.3
van Suylen, R.J.4
Griffioen, A.W.5
-
28
-
-
0345711604
-
Prognostic value of immunohistochemical expression of β1 integrin in pancreatic carcinoma
-
Bottger TC, Maschek H, Lobo M, Gottwohl RG, Brenner W, et al. (1999) Prognostic value of immunohistochemical expression of β1 integrin in pancreatic carcinoma. Oncology 56: 308-313.
-
(1999)
Oncology
, vol.56
, pp. 308-313
-
-
Bottger, T.C.1
Maschek, H.2
Lobo, M.3
Gottwohl, R.G.4
Brenner, W.5
-
29
-
-
1642319000
-
Integrin chains β1 and αV as prognostic factors in human metastatic melanoma
-
Nikkola J, Vihinen P, Vlaykova T, Hahka-Kemppinen M, Heino J, et al. (2004) Integrin chains β1 and αV as prognostic factors in human metastatic melanoma. Melanoma Res 14: 29-37.
-
(2004)
Melanoma Res
, vol.14
, pp. 29-37
-
-
Nikkola, J.1
Vihinen, P.2
Vlaykova, T.3
Hahka-Kemppinen, M.4
Heino, J.5
-
30
-
-
34447581074
-
Increased gene expression levels of collagen receptor integrins are associated with decreased survival parameters in patients with advanced melanoma
-
Vuoristo M, Vihinen P, Vlaykova T, Nylund C, Heino J, et al. (2007) Increased gene expression levels of collagen receptor integrins are associated with decreased survival parameters in patients with advanced melanoma. Melanoma Res 17: 215-223.
-
(2007)
Melanoma Res
, vol.17
, pp. 215-223
-
-
Vuoristo, M.1
Vihinen, P.2
Vlaykova, T.3
Nylund, C.4
Heino, J.5
-
31
-
-
78650940402
-
The α2β1 integrin is a metastasis suppressor in mouse models and human cancer
-
Ramirez NE, Zhang Z, Madamanchi A, Boyd KL, O'Rear LD, et al. (2011) The α2β1 integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest 121: 226-237.
-
(2011)
J Clin Invest
, vol.121
, pp. 226-237
-
-
Ramirez, N.E.1
Zhang, Z.2
Madamanchi, A.3
Boyd, K.L.4
O'Rear, L.D.5
-
32
-
-
0028978457
-
Re-expression of the α2β1 integrin abrogates the malignant phenotype of breast carcinoma cells
-
Zutter MM, Santoro SA, Staatz WD, Tsung YL, (1995) Re-expression of the α2β1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc Natl Acad Sci U S A 92: 7411-7415.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7411-7415
-
-
Zutter, M.M.1
Santoro, S.A.2
Staatz, W.D.3
Tsung, Y.L.4
-
33
-
-
4444259670
-
Tumor cell α3β1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis
-
Wang H, Fu W, Im JH, Zhou Z, Santoro SA, et al. (2004) Tumor cell α3β1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. J Cell Biol 164: 935-941.
-
(2004)
J Cell Biol
, vol.164
, pp. 935-941
-
-
Wang, H.1
Fu, W.2
Im, J.H.3
Zhou, Z.4
Santoro, S.A.5
-
34
-
-
82555189403
-
β1-integrin: a potential therapeutic target in the battle against cancer recurrence
-
Barkan D, Chambers AF, (2011) β1-integrin: a potential therapeutic target in the battle against cancer recurrence. Clin Cancer Res 17: 7219-7223.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7219-7223
-
-
Barkan, D.1
Chambers, A.F.2
-
36
-
-
79957621253
-
The insider's guide to leukocyte integrin signalling and function
-
Hogg N, Patzak I, Willenbrock F, (2011) The insider's guide to leukocyte integrin signalling and function. Nat Rev Immunol 11: 416-426.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 416-426
-
-
Hogg, N.1
Patzak, I.2
Willenbrock, F.3
-
37
-
-
67049155340
-
Talin-dependent integrin signalling in vivo
-
Petrich BG, (2009) Talin-dependent integrin signalling in vivo. Thromb Haemost 101: 1020-1024.
-
(2009)
Thromb Haemost
, vol.101
, pp. 1020-1024
-
-
Petrich, B.G.1
-
38
-
-
34547654194
-
The antithrombotic potential of selective blockade of talin-dependent integrin αIIbβ3 (platelet GPIIb-IIIa) activation
-
Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, et al. (2007) The antithrombotic potential of selective blockade of talin-dependent integrin αIIbβ3 (platelet GPIIb-IIIa) activation. J Clin Invest 117: 2250-2259.
-
(2007)
J Clin Invest
, vol.117
, pp. 2250-2259
-
-
Petrich, B.G.1
Fogelstrand, P.2
Partridge, A.W.3
Yousefi, N.4
Ablooglu, A.J.5
-
39
-
-
37549064277
-
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
-
Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, et al. (2007) Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 204: 3103-3111.
-
(2007)
J Exp Med
, vol.204
, pp. 3103-3111
-
-
Petrich, B.G.1
Marchese, P.2
Ruggeri, Z.M.3
Spiess, S.4
Weichert, R.A.5
-
40
-
-
37549029679
-
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo
-
Nieswandt B, Moser M, Pleines I, Varga-Szabo D, Monkley S, et al. (2007) Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med 204: 3113-3118.
-
(2007)
J Exp Med
, vol.204
, pp. 3113-3118
-
-
Nieswandt, B.1
Moser, M.2
Pleines, I.3
Varga-Szabo, D.4
Monkley, S.5
-
41
-
-
0034678129
-
Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin α2β1
-
Jung SM, Moroi M, (2000) Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin α2β1. J Biol Chem 275: 8016-8026.
-
(2000)
J Biol Chem
, vol.275
, pp. 8016-8026
-
-
Jung, S.M.1
Moroi, M.2
-
42
-
-
70350574674
-
An integrin αVβ3-c-Src oncogenic unit promotes anchorage-independence and tumor progression
-
Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, et al. (2009) An integrin αVβ3-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med 15: 1163-1169.
-
(2009)
Nat Med
, vol.15
, pp. 1163-1169
-
-
Desgrosellier, J.S.1
Barnes, L.A.2
Shields, D.J.3
Huang, M.4
Lau, S.K.5
-
43
-
-
0026460174
-
A point mutation of integrin β1 subunit blocks binding of α5β1 to fibronectin and invasin but not recruitment to adhesion plaques
-
Takada Y, Ylanne J, Mandelman D, Puzon W, Ginsberg MH, (1992) A point mutation of integrin β1 subunit blocks binding of α5β1 to fibronectin and invasin but not recruitment to adhesion plaques. J Cell Biol 119: 913-921.
-
(1992)
J Cell Biol
, vol.119
, pp. 913-921
-
-
Takada, Y.1
Ylanne, J.2
Mandelman, D.3
Puzon, W.4
Ginsberg, M.H.5
-
44
-
-
44449148944
-
The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate β1 and β3 integrins
-
Bouaouina M, Lad Y, Calderwood DA, (2008) The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate β1 and β3 integrins. J Biol Chem 283: 6118-6125.
-
(2008)
J Biol Chem
, vol.283
, pp. 6118-6125
-
-
Bouaouina, M.1
Lad, Y.2
Calderwood, D.A.3
-
45
-
-
0033213922
-
The Talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation
-
Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, et al. (1999) The Talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation. J Biol Chem 274: 28071-28074.
-
(1999)
J Biol Chem
, vol.274
, pp. 28071-28074
-
-
Calderwood, D.A.1
Zent, R.2
Grant, R.3
Rees, D.J.4
Hynes, R.O.5
-
46
-
-
33845987101
-
Structural basis of integrin activation by talin
-
Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, et al. (2007) Structural basis of integrin activation by talin. Cell 128: 171-182.
-
(2007)
Cell
, vol.128
, pp. 171-182
-
-
Wegener, K.L.1
Partridge, A.W.2
Han, J.3
Pickford, A.R.4
Liddington, R.C.5
-
47
-
-
58349118949
-
Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration
-
Zheng H, Gao L, Feng Y, Yuan L, Zhao H, et al. (2009) Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Cancer Res 69: 449-457.
-
(2009)
Cancer Res
, vol.69
, pp. 449-457
-
-
Zheng, H.1
Gao, L.2
Feng, Y.3
Yuan, L.4
Zhao, H.5
-
48
-
-
15044359236
-
Linking Rap to cell adhesion
-
Bos JL, (2005) Linking Rap to cell adhesion. Curr Opin Cell Biol 17: 123-128.
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 123-128
-
-
Bos, J.L.1
-
49
-
-
0027421094
-
A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin α6β1
-
Lenter M, Uhlig H, Hamann A, Jeno P, Imhof B, et al. (1993) A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin α6β1. Proc Natl Acad Sci U S A 90: 9051-9055.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 9051-9055
-
-
Lenter, M.1
Uhlig, H.2
Hamann, A.3
Jeno, P.4
Imhof, B.5
-
50
-
-
0028858576
-
Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium
-
Bazzoni G, Shih DT, Buck CA, Hemler ME, (1995) Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem 270: 25570-25577.
-
(1995)
J Biol Chem
, vol.270
, pp. 25570-25577
-
-
Bazzoni, G.1
Shih, D.T.2
Buck, C.A.3
Hemler, M.E.4
-
51
-
-
0035852648
-
Integrin activation controls metastasis in human breast cancer
-
Felding-Habermann B, O'Toole TE, Smith JW, Fransvea E, Ruggeri ZM, et al. (2001) Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A 98: 1853-1858.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1853-1858
-
-
Felding-Habermann, B.1
O'Toole, T.E.2
Smith, J.W.3
Fransvea, E.4
Ruggeri, Z.M.5
-
52
-
-
84855846740
-
Engagement of αIIbβ3 (GPIIb/IIIa) with αVβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis
-
Lonsdorf AS, Kramer BF, Fahrleitner M, Schonberger T, Gnerlich S, et al. (2012) Engagement of αIIbβ3 (GPIIb/IIIa) with αVβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis. J Biol Chem 287: 2168-2178.
-
(2012)
J Biol Chem
, vol.287
, pp. 2168-2178
-
-
Lonsdorf, A.S.1
Kramer, B.F.2
Fahrleitner, M.3
Schonberger, T.4
Gnerlich, S.5
-
53
-
-
0033559946
-
Lysis of tumor cells by natural killer cells in mice is impeded by platelets
-
Nieswandt B, Hafner M, Echtenacher B, Mannel DN, (1999) Lysis of tumor cells by natural killer cells in mice is impeded by platelets. CancerRes 59: 1295-1300.
-
(1999)
CancerRes
, vol.59
, pp. 1295-1300
-
-
Nieswandt, B.1
Hafner, M.2
Echtenacher, B.3
Mannel, D.N.4
-
54
-
-
0036790996
-
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling
-
Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, et al. (2002) Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A 99: 12819-12824.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 12819-12824
-
-
Eto, K.1
Murphy, R.2
Kerrigan, S.W.3
Bertoni, A.4
Stuhlmann, H.5
-
55
-
-
0141865705
-
Talin binding to integrin β tails: a final common step in integrin activation
-
Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, et al. (2003) Talin binding to integrin β tails: a final common step in integrin activation. Science 302: 103-106.
-
(2003)
Science
, vol.302
, pp. 103-106
-
-
Tadokoro, S.1
Shattil, S.J.2
Eto, K.3
Tai, V.4
Liddington, R.C.5
-
56
-
-
79956303516
-
Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells
-
Hernandez-Varas P, Colo GP, Bartolome RA, Paterson A, Medrano-Fernandez I, et al. (2011) Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells. J Biol Chem 286: 18492-18504.
-
(2011)
J Biol Chem
, vol.286
, pp. 18492-18504
-
-
Hernandez-Varas, P.1
Colo, G.P.2
Bartolome, R.A.3
Paterson, A.4
Medrano-Fernandez, I.5
-
57
-
-
77953156239
-
Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs
-
Freeman SA, McLeod SJ, Dukowski J, Austin P, Lee CC, et al. (2010) Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. Cancer Res 70: 4590-4601.
-
(2010)
Cancer Res
, vol.70
, pp. 4590-4601
-
-
Freeman, S.A.1
McLeod, S.J.2
Dukowski, J.3
Austin, P.4
Lee, C.C.5
-
58
-
-
77950203804
-
Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance
-
Sakamoto S, McCann RO, Dhir R, Kyprianou N, (2010) Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance. Cancer Res 70: 1885-1895.
-
(2010)
Cancer Res
, vol.70
, pp. 1885-1895
-
-
Sakamoto, S.1
McCann, R.O.2
Dhir, R.3
Kyprianou, N.4
-
59
-
-
84856101033
-
Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer
-
Shen Z, Ye Y, Dong L, Vainionpaa S, Mustonen H, et al. (2012) Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer. Am J Surg 203: 222-229.
-
(2012)
Am J Surg
, vol.203
, pp. 222-229
-
-
Shen, Z.1
Ye, Y.2
Dong, L.3
Vainionpaa, S.4
Mustonen, H.5
-
60
-
-
80052660725
-
Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis
-
Sin S, Bonin F, Petit V, Meseure D, Lallemand F, et al. (2011) Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis. J Natl Cancer Inst 103: 1323-1337.
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 1323-1337
-
-
Sin, S.1
Bonin, F.2
Petit, V.3
Meseure, D.4
Lallemand, F.5
-
61
-
-
77956634187
-
Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration
-
An Z, Dobra K, Lock JG, Stromblad S, Hjerpe A, et al. (2010) Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration. Internat Cancer 127: 1999-2008.
-
(2010)
Internat Cancer
, vol.127
, pp. 1999-2008
-
-
An, Z.1
Dobra, K.2
Lock, J.G.3
Stromblad, S.4
Hjerpe, A.5
-
62
-
-
69549114537
-
Kindling the flame of integrin activation and function with kindlins
-
Plow EF, Qin J, Byzova T, (2009) Kindling the flame of integrin activation and function with kindlins. Curr Opin Hematol 16: 323-328.
-
(2009)
Curr Opin Hematol
, vol.16
, pp. 323-328
-
-
Plow, E.F.1
Qin, J.2
Byzova, T.3
-
63
-
-
66149128873
-
The tail of integrins, talin, and kindlins
-
Moser M, Legate KR, Zent R, Fassler R, (2009) The tail of integrins, talin, and kindlins. Science 324: 895-899.
-
(2009)
Science
, vol.324
, pp. 895-899
-
-
Moser, M.1
Legate, K.R.2
Zent, R.3
Fassler, R.4
-
64
-
-
80455143827
-
SHARPIN is an endogenous inhibitor of β1-integrin activation
-
Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, et al. (2011) SHARPIN is an endogenous inhibitor of β1-integrin activation. Nat Cell Biol 13: 1315-1324.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1315-1324
-
-
Rantala, J.K.1
Pouwels, J.2
Pellinen, T.3
Veltel, S.4
Laasola, P.5
-
65
-
-
78650018068
-
Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion
-
Nevo J, Mai A, Tuomi S, Pellinen T, Pentikainen OT, et al. (2010) Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion. Oncogene 29: 6452-6463.
-
(2010)
Oncogene
, vol.29
, pp. 6452-6463
-
-
Nevo, J.1
Mai, A.2
Tuomi, S.3
Pellinen, T.4
Pentikainen, O.T.5
-
66
-
-
84858135544
-
A functional genetic screen reveals new regulators of β1-integrin activity
-
Pellinen T, Rantala JK, Arjonen A, Mpindi JP, Kallioniemi O, et al. (2012) A functional genetic screen reveals new regulators of β1-integrin activity. J Cell Sci 125: 649-661.
-
(2012)
J Cell Sci
, vol.125
, pp. 649-661
-
-
Pellinen, T.1
Rantala, J.K.2
Arjonen, A.3
Mpindi, J.P.4
Kallioniemi, O.5
-
67
-
-
51049100594
-
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
-
Zhang X, Jiang G, Cai Y, Monkley SJ, Critchley DR, et al. (2008) Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol 10: 1062-1068.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1062-1068
-
-
Zhang, X.1
Jiang, G.2
Cai, Y.3
Monkley, S.J.4
Critchley, D.R.5
-
68
-
-
0037422583
-
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
-
Qin XF, An DS, Chen IS, Baltimore D, (2003) Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A 100: 183-188.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 183-188
-
-
Qin, X.F.1
An, D.S.2
Chen, I.S.3
Baltimore, D.4
-
69
-
-
0037062424
-
A monomeric red fluorescent protein
-
Campbell RE, Tour O, Palmer AE, Steinbach PA, Baird GS, et al. (2002) A monomeric red fluorescent protein. Proc Natl Acad Sci U S A 99: 7877-7882.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 7877-7882
-
-
Campbell, R.E.1
Tour, O.2
Palmer, A.E.3
Steinbach, P.A.4
Baird, G.S.5
-
70
-
-
77954352788
-
Visualizing extravasation dynamics of metastatic tumor cells
-
Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, et al. (2010) Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci 123: 2332-2341.
-
(2010)
J Cell Sci
, vol.123
, pp. 2332-2341
-
-
Stoletov, K.1
Kato, H.2
Zardouzian, E.3
Kelber, J.4
Yang, J.5
-
71
-
-
0013307787
-
Conformational changes in the integrin βA domain provide a mechanism for signal transduction via hybrid domain movement
-
Mould AP, Barton SJ, Askari JA, McEwan PA, Buckley PA, et al. (2003) Conformational changes in the integrin βA domain provide a mechanism for signal transduction via hybrid domain movement. J Biol Chem 278: 17028-17035.
-
(2003)
J Biol Chem
, vol.278
, pp. 17028-17035
-
-
Mould, A.P.1
Barton, S.J.2
Askari, J.A.3
McEwan, P.A.4
Buckley, P.A.5
-
72
-
-
46249121793
-
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3
-
Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, et al. (2008) Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3. J Cell Biol 181: 1211-1222.
-
(2008)
J Cell Biol
, vol.181
, pp. 1211-1222
-
-
Watanabe, N.1
Bodin, L.2
Pandey, M.3
Krause, M.4
Coughlin, S.5
-
73
-
-
0025781381
-
Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex
-
Sims PJ, Ginsberg MH, Plow EF, Shattil SJ, (1991) Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J Biol Chem 266: 7345-7352.
-
(1991)
J Biol Chem
, vol.266
, pp. 7345-7352
-
-
Sims, P.J.1
Ginsberg, M.H.2
Plow, E.F.3
Shattil, S.J.4
-
74
-
-
23844457919
-
Specification of the direction of adhesive signaling by the integrin β cytoplasmic domain
-
Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH, (2005) Specification of the direction of adhesive signaling by the integrin β cytoplasmic domain. J Biol Chem 280: 29699-29707.
-
(2005)
J Biol Chem
, vol.280
, pp. 29699-29707
-
-
Arias-Salgado, E.G.1
Lizano, S.2
Shattil, S.J.3
Ginsberg, M.H.4
-
75
-
-
0037067748
-
Relationships between Rap1b, affinity modulation of integrin αIIbβ3, and the actin cytoskeleton
-
Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, et al. (2002) Relationships between Rap1b, affinity modulation of integrin αIIbβ3, and the actin cytoskeleton. J Biol Chem 277: 25715-25721.
-
(2002)
J Biol Chem
, vol.277
, pp. 25715-25721
-
-
Bertoni, A.1
Tadokoro, S.2
Eto, K.3
Pampori, N.4
Parise, L.V.5
-
76
-
-
28244495575
-
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination
-
Deryugina EI, Zijlstra A, Partridge JJ, Kupriyanova TA, Madsen MA, et al. (2005) Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. Cancer Res 65: 10959-10969.
-
(2005)
Cancer Res
, vol.65
, pp. 10959-10969
-
-
Deryugina, E.I.1
Zijlstra, A.2
Partridge, J.J.3
Kupriyanova, T.A.4
Madsen, M.A.5
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