Significance of integrin α5 gene expression as a prognostic factor in node-negative non-small cell lung cancer

Clinical Cancer Research

Volumn 6, Issue 1, 2000, Pages 96-101

  Adachi, Masashi ^a   Taki, Toshihiko ^a   Higashiyama, Masahiko ^b   Kohno, Nobuoki ^c   Inufusa, Haruhiko ^d   Miyake, Masayuki ^a  

^a Kitano Hospital   (Japan)

^b CENTER FOR ADULT DISEASES   (Japan)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MARKER; INTEGRIN; ALPHA5 INTEGRIN; LEUKOCYTE ANTIGEN; TUMOR MARKER;

ARTICLE; CANCER CELL CULTURE; DISEASE COURSE; DISEASE MARKER; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; TUMOR GROWTH; AGED; CELL CULTURE; GENETICS; LUNG TUMOR; MIDDLE AGED; MORTALITY; PATHOLOGY; PREDICTION AND FORECASTING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL; TIME;

AGED; ANTIGENS, CD; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA5; LUNG NEOPLASMS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0033621689     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Hart, I. R., and Saini, A. Biology of tumor metastasis. Lancet, 339: 1453-1457, 1992.
2. Liotta, L. A., Steeg, P. S., and Stetlet-Stevenson, W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64: 327-336, 1991.
3. Ruoslahti, E., and Giancotti, F. G. Integrins and tumor cell dissemination. Cancer Cells, 1: 119-126, 1989.
4. Hynes, R. O. Integrins: a family of cell surface receptors. Cell, 48: 549-554, 1987.
5. Hynes, R. O. Integrins: Versatility, modulation, and signaling in cell adhesion. Cell, 69: 11-25, 1992.
6. Ginsberg, M. H., Du, X., and Plow, E. F. Inside-out integrin signaling. Curr. Opin. Cell Biol., 4: 766-771, 1992.
7. Akiyama, S. K., Yamada, S. S., Chen, W. T., and Yamada, K. M. Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J. Cell Biol., 109: 863-875, 1989.
8. Werb, Z., Tremble, P. M., Behrendsten, O., Crowley, E., and Damsky, C. H. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J. Cell Biol., 109: 877-889, 1989.
9. Blystone, S. D., Graham, I. L., Lindberg, F. P., and Brown, E. J. Integrin αvβ3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor α5β1. J. Cell Biol., 127: 1129-1137, 1994.
10. Wang, D., Zhou, G., Birkenmeier, T. M., Gong, J., Sun, L., and Brattain, M. G. Autocrine transforming growth factor β1 modulates the expression of integrin α5β1 in human colon carcinoma FET cells. J. Biol. Chem., 270: 14154-14159, 1995.
11. Giancotti, F. G., and Ruoslahti, E. Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell, 60: 849-859, 1990.
12. Dedhar, S., Argraves, W. S., Suzuki, S., Ruoslahti, E., and Pierschbacher, M. D. Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor. J. Cell Biol., 105: 1175-1182, 1987.
13. Plantefaber, L. C., and Hynes, R. O. Changes in integrin receptors on oncogenically transformed cells. Cell, 56: 281-290, 1989.
14. Tennenbaum, T., Yuspa, S. H., Grover, A., Castronovo, V., Sobel, M. E., Yamada, Y., and De Luca, L. M. Extracellular matrix receptors and mouse skin carcinogenesis: altered expression linked to appearance of early markers of tumor progression. Cancer Res., 52: 2966-2976, 1992.
15. Danen, E. H. J., Ten Berge, P. J. M., Van Muijen, G. N. P., Van't Hof-Grootenboer, A. E., Brocker, E. B., and Ruiter, D. J. Emergence of α5β1 fibronectin- and αvβ3 vitronectin-receptor expression in melanocytic tumor progression. Histopathology, 24: 249-256, 1994.
16. Natali, P. G., Nicotra, M. R., Di Filippo, F., and Bigotti, A. Expression of fibronectin, fibronectin isoforms and integrin receptors melanocytic lesions. Br. J. Cancer, 71: 1243-1247, 1995.
17. Gomez, M., and Cano, A. Expression of β1 integrin receptors in transformed mouse epidermal keratinocytes: Upregulation of α5β1 in spindle carcinoma cells. Mol. Carcinog., 12: 153-165, 1995.
18. Libert, M., Washington, R., Stein, J., Wedemeyer, G., and Grossman, H. B. Expression of the VLA β1 integrin family in bladder cancer. Am. J. Pathol., 144: 1016-1022, 1994.
19. Lessey, B. A., Albelda, S., Buck, C. A., Castelbaum, A. J., Yeh, I., Kohler, M., and Berchuck, A. Distribution of integrin cell adhesion molecules in endometrial cancer. Am. J. Pathol., 146: 717-726, 1995.
20. Schiller, J. H., and Bittner, G. Loss of the tumorigenic phenotype with in vitro, but not in vivo, passaging of a novel series of human bronchial epithelial cell lines: possible role of an α5/β1-integrin-fibronectin interaction. Cancer Res., 55: 6215-6221, 1995.
21. Suzuki, S., Takahashi, T., Nakamura, S., Koike, K., Ariyoshi, Y., Takahashi, T., and Ueda, R. Alterations of integrin expression in human lung cancer. Jpn. J. Cancer Res., 84: 168-174, 1993.
22. Albelda, S. M. Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab. Invest., 68: 4-17, 1993.
23. Clifton, F., and Mountain, M. D. Revisions in the international system for staging lung cancer. Chest, 111: 1710-1717, 1997.
24. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
25. Argraves, W. S., Suzuki, S., Arai, H., Thompson, K., Pierschbacher, M. D. and Ruoslahti, E. Amino acid sequence of the human fibronectin receptor. J. Cell Biol., 105: 1183-1190, 1987.
26. Nakajima-Iijima, S., Hamada, H., Reddy, P., and Kakunaga, T. Molecular structure of the human cytoplasmic β-actin gene: interspecies homology of sequences in the introns. Proc. Natl. Acad. Sci. USA, 82: 6133-6137, 1985.
27. Kaplan, E. L., and Meier, P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc., 53: 457-481, 1958.
28. Mantel, N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother. Rep., 50: 163-170, 1966.
29. Varner, J. A., Emerson, D. A., and Juliano, R. L. Integrin α5β1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol. Biol. Cell, 6: 725-740, 1995.
30. Zhang, Z., Vuori, K., Reed, J. C., and Ruoslahti, E. The α5β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc. Natl. Acad. Sci. USA, 92: 6161-6165, 1995.
31. O'Brien, V., Frisch, S. M., and Juliano, R. L. Expression of the integrin α subunit in HT29 colon carcinoma cells suppresses apoptosis triggered by serum deprivation. Exp. Cell Res., 224: 208-213, 1996.
32. Humphries, M. J., Olden, K., and Yamada, K. M. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science (Washington DC), 233: 467-470, 1986.
33. Saiki, I., Iida, J., Murata, J., Ogawa, R., Nishi, N., Sugimura, K., Tokura, S., and Azuma, I. Inhibition of the metastasis of murine malignant melanoma by synthetic polymeric peptides containing core sequences of cell-adhesive molecules. Cancer Res., 49: 3815-3822, 1989.
34. Murthy, M. S., Reid, S. E. Jr, Yang, X., and Scanlon, E. F. The potential role of integrin receptor subunits in the formation of local recurrence and distant metastasis by mouse breast cancer cells. J. Surg. Oncol., 63: 77-86, 1996.