A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 40, 2012, Pages 16125-16130

  Seol, Yeonee ^a   Zhang, Hongliang ^b   Pommier, Yves ^b   Neuman, Keir C ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer therapy; Magnetic tweezers; Single molecule biophysics

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE; MITOCHONDRIAL PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; DNA REPAIR; DNA SUPERCOILING; ENZYME ACTIVITY; ENZYME SUBSTRATE; INHIBITION KINETICS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; SENSITIVITY ANALYSIS; TORQUE;

BASE SEQUENCE; BIOMECHANICS; BIOPHYSICS; CAMPTOTHECIN; CELL NUCLEUS; DNA REPLICATION; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; NUCLEIC ACID CONFORMATION; ROTATION; SEQUENCE HOMOLOGY; TOPOISOMERASE I INHIBITORS; TORQUE; TRANSCRIPTION, GENETIC;

EID: 84867042552     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1206480109     Document Type: Article

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