Free energy calculations reveal rotating-ratchet mechanism for DNA supercoil relaxation by topoisomerase IB and its inhibition

Biophysical Journal

Volumn 99, Issue 3, 2010, Pages 869-878

  Wereszczynski, Jeff ^a,b   Andricioaei, Ioan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA SUPERCOILING; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; TOP1 PROTEIN, HUMAN;

BIOLOGICAL MODEL; CHEMISTRY; DNA SUPERCOILING; HUMAN; KINETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE; ROTATION; THERMODYNAMICS;

DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; HUMANS; KINETICS; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, SECONDARY; ROTATION; THERMODYNAMICS; TOPOISOMERASE I INHIBITORS;

EID: 77955692216     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.04.077     Document Type: Article

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