메뉴 건너뛰기




Volumn 12, Issue 12, 2002, Pages 1763-1782

Patent focus on cancer chemotherapeutics V. Angiogenesis agents: September 2001 - August 2002

Author keywords

632; Angiogenesis; Antiangiogenesis; CEP 5214; CEP 7055; CP 547; DC101; Fibroblast growth factor (FGF); Fibroblast growth factor receptor (FGFR); Platelet derived growth factor receptor (PDGFR); PTK 787; Receptor tyrosine kinases inhibitor (TKI); SU 5416; SU 6668; Tie 2; Vascular endothelial growth factor (VEGF); Vascular endothelial growth factor receptor (VEGFR); ZD 6474

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 [6 METHOXY 7 [3 (1 PIPERIDINYL)PROPOXY] 4 QUINAZOLINYL] 1 PIPERAZINECARBOXYLIC ACID (4 ISOPROPOXYPHENYL)AMIDE; ANGIOGENESIS INHIBITOR; ANGIOPOIETIN; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; FLT3 LIGAND; IMATINIB; IMIDAZOLE DERIVATIVE; NAPHTHYRIDINE DERIVATIVE; PENTRAXIN; PHTHALAZINE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; SEMAXANIB; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 0036928020     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.12.12.1763     Document Type: Article
Times cited : (17)

References (34)
  • 2
    • 0036196711 scopus 로고    scopus 로고
    • Antiangiogenic strategies and vascular targeting in the treatment of lung cancer
    • BROCK CS, LEE SM: Antiangiogenic strategies and vascular targeting in the treatment of lung cancer. Eur. Resp. J. (2002) 19(3):557-570.
    • (2002) Eur. Resp. J. , vol.19 , Issue.3 , pp. 557-570
    • Brock, C.S.1    Lee, S.M.2
  • 4
    • 0036134344 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: A clinical perspective
    • GOEL S, MANI S, PEREZ-SOLER R: Tyrosine kinase inhibitors: a clinical perspective. Current Oncology Reports (2002) 4(1):9-19.
    • (2002) Current Oncology Reports , vol.4 , Issue.1 , pp. 9-19
    • Goel, S.1    Mani, S.2    Perez-Soler, R.3
  • 5
    • 0034120431 scopus 로고    scopus 로고
    • Cancer chemotherapeutics - Angiogenesis agents: October 1999 - March 2000
    • CONNELL RD: Cancer chemotherapeutics - angiogenesis agents: October 1999 - March 2000. Expert Opin. Ther. Patents (2000) 10(6):767-786.
    • (2000) Expert Opin. Ther. Patents , vol.10 , Issue.6 , pp. 767-786
    • Connell, R.D.1
  • 6
    • 0035184875 scopus 로고    scopus 로고
    • Patent focus on cancer chemotherapeutics. II angiogenesis agents: April 2000 - September (2000)
    • CONNELL RD, BEEBE JS: Patent focus on cancer chemotherapeutics. II angiogenesis agents: April 2000 - September (2000). Expert Opin. Ther. Patents (2001) 11(1):77-114.
    • (2001) Expert Opin. Ther. Patents , vol.11 , Issue.1 , pp. 77-114
    • Connell, R.D.1    Beebe, J.S.2
  • 7
    • 0034945439 scopus 로고    scopus 로고
    • Patent focus on cancer chemotherapeutics. III Angiogenesis agents: October 2000 - March 2001
    • CONNELL RD, BEEBE JS: Patent focus on cancer chemotherapeutics. III Angiogenesis agents: October 2000 - March 2001. Expert Opin. Ther. Patents (2001) 11(7):1171-1203.
    • (2001) Expert Opin. Ther. Patents , vol.11 , Issue.7 , pp. 1171-1203
    • Connell, R.D.1    Beebe, J.S.2
  • 8
    • 0035207826 scopus 로고    scopus 로고
    • Patent focus on cancer chemotherapeutics. IV Angiogenesis agents: April 2001 - August 2001
    • CONNELL RD, BEEBE JS: Patent focus on cancer chemotherapeutics. IV Angiogenesis agents: April 2001 - August 2001. Expert Opin. Ther. Patents (2001) 11(12):1919-1945.
    • (2001) Expert Opin. Ther. Patents , vol.11 , Issue.12 , pp. 1919-1945
    • Connell, R.D.1    Beebe, J.S.2
  • 9
    • 0036109679 scopus 로고    scopus 로고
    • MT-MMPs play pivotal roles in cancer dissemination
    • YANA I, SEIKI M: MT-MMPs play pivotal roles in cancer dissemination. Clin. Exp. Metastasis (2002) 19(3):209-215.
    • (2002) Clin. Exp. Metastasis , vol.19 , Issue.3 , pp. 209-215
    • Yana, I.1    Seiki, M.2
  • 10
    • 0037052641 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets
    • VIHINEN P, KAHARI VM: Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int. J. Cancer (2002) 99(2):157-166.
    • (2002) Int. J. Cancer , vol.99 , Issue.2 , pp. 157-166
    • Vihinen, P.1    Kahari, V.M.2
  • 11
    • 0036252855 scopus 로고    scopus 로고
    • Matrix metalloproteinases and angiogenesis
    • JACKSON C: Matrix metalloproteinases and angiogenesis. Curr. Opin. Nephrol. Hyperten. (2002) 11(3):295-299.
    • (2002) Curr. Opin. Nephrol. Hyperten. , vol.11 , Issue.3 , pp. 295-299
    • Jackson, C.1
  • 12
    • 0036113090 scopus 로고    scopus 로고
    • Therapeutic developments in matrix metalloproteinase inhibition
    • DOHERTY TM, ASOTRA K, PEI DQ et al.: Therapeutic developments in matrix metalloproteinase inhibition. Expert Opin. Ther. Patents (2002) 12(5):665-707.
    • (2002) Expert Opin. Ther. Patents , vol.12 , Issue.5 , pp. 665-707
    • Doherty, T.M.1    Asotra, K.2    Pei, D.Q.3
  • 13
    • 0035524007 scopus 로고    scopus 로고
    • Integrins as targets of angiogenesis inhibition
    • WESTLIN WF: Integrins as targets of angiogenesis inhibition. Cancer J. (2001) 7(Suppl. 3):S139-43.
    • (2001) Cancer J. , vol.7 , Issue.SUPPL. 3
    • Westlin, W.F.1
  • 14
    • 0036091414 scopus 로고    scopus 로고
    • The role of α(v)β(3) in prostate cancer progression
    • COOPER CR, CHAY CH, PIENTA KJ: The role of α(v)β(3) in prostate cancer progression. Neoplasia (2002) 4(3):191-194.
    • (2002) Neoplasia , vol.4 , Issue.3 , pp. 191-194
    • Cooper, C.R.1    Chay, C.H.2    Pienta, K.J.3
  • 15
    • 0034693811 scopus 로고    scopus 로고
    • Development of inhibitors for protein tyrosine kinases
    • AL-OBEIDI FA, LAM KS: Development of inhibitors for protein tyrosine kinases. Oncogene (2000) 19:5690-5701.
    • (2000) Oncogene , vol.19 , pp. 5690-5701
    • Al-Obeidi, F.A.1    Lam, K.S.2
  • 16
    • 0001854511 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors as therapeutic agents
    • LEVITZKI A: Protein tyrosine kinase inhibitors as therapeutic agents. Bioorg. Chem. Biol. Signal Transduction (2001) 211:1-15.
    • (2001) Bioorg. Chem. Biol. Signal Transduction , vol.211 , pp. 1-15
    • Levitzki, A.1
  • 17
    • 0035117012 scopus 로고    scopus 로고
    • Protein kinase inhibitors: Emerging pharmacophores 1997 - 2000
    • DUMAS J: Protein kinase inhibitors: emerging pharmacophores 1997 - 2000. Expert Opin. Ther. Patents (2001) 11(3):405-429.
    • (2001) Expert Opin. Ther. Patents , vol.11 , Issue.3 , pp. 405-429
    • Dumas, J.1
  • 18
    • 0036139884 scopus 로고    scopus 로고
    • Receptor tyrosine kinases as targets for anticancer drugs
    • ZWICK E, BANGE J, ULLRICH A: Receptor tyrosine kinases as targets for anticancer drugs. Trends Mol. Med. (2002) 8(1):17-23.
    • (2002) Trends Mol. Med. , vol.8 , Issue.1 , pp. 17-23
    • Zwick, E.1    Bange, J.2    Ullrich, A.3
  • 19
    • 0035336732 scopus 로고    scopus 로고
    • Monoclonal antibody strategies to block angiogenesis
    • HICKLIN DJ, WITTE L, ZHU ZP et al.: Monoclonal antibody strategies to block angiogenesis. Drug Discovery Today (2001) 6(10):517-528.
    • (2001) Drug Discovery Today , vol.6 , Issue.10 , pp. 517-528
    • Hicklin, D.J.1    Witte, L.2    Zhu, Z.P.3
  • 20
    • 0035145117 scopus 로고    scopus 로고
    • Angiopoietin growth factors and Tie receptor tyrosine kinases in renal vascular development
    • WOOLF AS, YUAN HT: Angiopoietin growth factors and Tie receptor tyrosine kinases in renal vascular development. Pediatric Nephrology (2001) 16(2):177-184.
    • (2001) Pediatric Nephrology , vol.16 , Issue.2 , pp. 177-184
    • Woolf, A.S.1    Yuan, H.T.2
  • 22
    • 0012252052 scopus 로고    scopus 로고
    • Abbott confident Synthroid will stay on US market Scrip, July 2
    • Abbott confident Synthroid will stay on US market Scrip, July 2, 2001.
    • (2001)
  • 23
    • 0034435424 scopus 로고    scopus 로고
    • Structure of the Tie2 RTK domain: Self-inhibition by the nucleotide binding loop, activation loop and C-terminal tail
    • SHEWCHUK LM, HASSELL AM, ELLIS B et al.: Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop and C-terminal tail. Structure (2000) 8(11):1105-1113.
    • (2000) Structure , vol.8 , Issue.11 , pp. 1105-1113
    • Shewchuk, L.M.1    Hassell, A.M.2    Ellis, B.3
  • 24
    • 0035300470 scopus 로고    scopus 로고
    • Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis
    • JEFFERS M, SHIMKETS R, PRAYAGA S et al.: Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis. Cancer Res. (2001) 61(7):3131-3138.
    • (2001) Cancer Res. , vol.61 , Issue.7 , pp. 3131-3138
    • Jeffers, M.1    Shimkets, R.2    Prayaga, S.3
  • 25
    • 0003670169 scopus 로고    scopus 로고
    • Discovery of CT53518, a potent and oral inhibitor of FLT3 kinase targeted for the treatment of acute myelogenous leukaemia
    • 223rd ACS National Meeting, Orlando, USA MEDI 19
    • PANDEY A, VOLKOTS DL, SEROOGY J et al.: Discovery of CT53518, a potent and oral inhibitor of FLT3 kinase targeted for the treatment of acute myelogenous leukaemia. 223rd ACS National Meeting, Orlando, USA (2002) MEDI 19.
    • (2002)
    • Pandey, A.1    Volkots, D.L.2    Seroogy, J.3
  • 26
    • 0037075812 scopus 로고    scopus 로고
    • Novel 4-anilinoquinazolines with C-7 basic side chains: Design and structure-activity relationship of a series of potent, orally-active, VEGF receptor tyrosine kinase inhibitors
    • HENNEQUIN LF, STOKES ESE, THOMAS AP et al.: Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure-activity relationship of a series of potent, orally-active, VEGF receptor tyrosine kinase inhibitors. J. Med. Chem. (2002) 45(6):1300-1312.
    • (2002) J. Med. Chem. , vol.45 , Issue.6 , pp. 1300-1312
    • Hennequin, L.F.1    Stokes, E.S.E.2    Thomas, A.P.3
  • 27
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumour growth after oral administration
    • WOOD JM, BOLD G, BUCHDUNGER E et al.: PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumour growth after oral administration. Cancer Res. (2000) 60(8):2178-89.
    • (2000) Cancer Res. , vol.60 , Issue.8 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3
  • 28
    • 0036125150 scopus 로고    scopus 로고
    • CGP 79787D (PTK787/ZK222584), CGP 84738 NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylmethyl)phthalazines as inhibitors of VEGF- and bFGF-induced angiogenesis
    • BOLD G, FREI J, FURET P et al.: CGP 79787D (PTK787/ZK222584), CGP 84738 NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylmethyl)phthalazines as inhibitors of VEGF- and bFGF-induced angiogenesis. Drugs of the Future (2002) 27(1):43-55.
    • (2002) Drugs of the Future , vol.27 , Issue.1 , pp. 43-55
    • Bold, G.1    Frei, J.2    Furet, P.3
  • 29
    • 0037099598 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumour vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
    • DREVS J, MULLER-DRIVER R, WITTIG C et al.: PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumour vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. Cancer Res. (2002) 62(14):4015-4022.
    • (2002) Cancer Res. , vol.62 , Issue.14 , pp. 4015-4022
    • Drevs, J.1    Muller-Driver, R.2    Wittig, C.3
  • 30
    • 0012253281 scopus 로고    scopus 로고
    • Development of 3-aryl- 5-(3-indolyl)pyridines as a novel class of KDR kinase inhibitors
    • 223rd ACS National Meeting, Orlando, USA MEDI 187
    • ARRINGTON KL, COLL KE, FRALEY ME et al.: Development of 3-aryl- 5-(3-indolyl)pyridines as a novel class of KDR kinase inhibitors. 223rd ACS National Meeting, Orlando, USA (2002) MEDI 187.
    • (2002)
    • Arrington, K.L.1    Coll, K.E.2    Fraley, M.E.3
  • 31
    • 0012315599 scopus 로고    scopus 로고
    • Design and synthesis of 2- acylamino-5-arylsubstituted oxazoles as kinase inhibitors of the VEGF receptor KDR
    • 223rd ACS National Meeting, Orlando, USA MEDI 181
    • HOFFMAN WF, ARRINGTON KL, COLL KE et al.: Design and synthesis of 2- acylamino-5-arylsubstituted oxazoles as kinase inhibitors of the VEGF receptor KDR. 223rd ACS National Meeting, Orlando, USA (2002) MEDI 181.
    • (2002)
    • Hoffman, W.F.1    Arrington, K.L.2    Coll, K.E.3
  • 32
    • 0012312959 scopus 로고    scopus 로고
    • Development and in vivo evaluation of novel inhibitors of the VEGF receptor tyrosine kinase KDR (VEGFR-2)
    • 223rd ACS National Meeting Orlando, USA MEDI 261
    • BILODEAU MT, COLL KE, CUNNINGHAM AM et al.: Development and in vivo evaluation of novel inhibitors of the VEGF receptor tyrosine kinase KDR (VEGFR-2). 223rd ACS National Meeting Orlando, USA (2002) MEDI 261.
    • (2002)
    • Bilodeau, M.T.1    Coll, K.E.2    Cunningham, A.M.3
  • 33
    • 0012302725 scopus 로고    scopus 로고
    • Design, synthesis and in vitrolin vivo characterization of three novel classes of VEGFR-2 (KDR) kinase inhibitors
    • 93rd Annual meeting of the American Association of Cancer Research (AACR) San Francisco, CA, USA Abstract 3676
    • FRALEY ME, ARRINGTON KL, COLL KE et al.: Design, synthesis and in vitrolin vivo characterization of three novel classes of VEGFR-2 (KDR) kinase inhibitors. 93rd Annual meeting of the American Association of Cancer Research (AACR) San Francisco, CA, USA (2002) Abstract 3676.
    • (2002)
    • Fraley, M.E.1    Arrington, K.L.2    Coll, K.E.3
  • 34
    • 0012312961 scopus 로고    scopus 로고
    • A Phase I and biologic correlative study of an oral Vascular Endothelial Growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, CP-547,632, in patients (PTS) with advanced solid tumours
    • 38th annual meeting of the Amer. Soc. Clin. Oncol., Orlando FL, USA Abstract 334
    • TOLCHER A, KARP DD, O'LEARY JJ et al.: A Phase I and biologic correlative study of an oral Vascular Endothelial Growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, CP-547,632, in patients (PTS) with advanced solid tumours. 38th annual meeting of the Amer. Soc. Clin. Oncol., Orlando FL, USA (2002) Abstract 334
    • (2002)
    • Tolcher, A.1    Karp, D.D.2    O'Leary, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.