Utility of alkylaminoquinolinyl methanols as new antimalarial drugs

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 12, 2006, Pages 4132-4143

  Dow, G S ^a   Heady, T N ^a   Bhattacharjee, A K ^a   Caridha, D ^a   Gerena, L ^a   Gettayacamin, M ^b   Lanteri, C A ^a   Obaldia III, N ^c   Roncal, N ^a   Shearer, T ^a   Smith, P L ^a   Tungtaeng, A ^b   Wolf, L ^a   Cabezas, M ^a   Yourick, D ^a   Smith, K S ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b U S ARMY   (United States)

^c Tropical Medicine Research/Gorgas Memorial Institute   (Panama)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOQUINOLINYLMETHANOL DERIVATIVE; CYTOCHROME P450 2D6; MEFLOQUINE; METHANOL; PIPERIDINE; QUINOLINE DERIVATIVE; UNINDEXED DRUG; WR 007524; WR 029252; WR 029656; WR 030090; WR 030091; WR 030464; WR 035058; WR 041294; WR 053188; WR 069878; WR 074086; WR 081049; WR 091884; WR 098656; WR 106751; WR 106752; WR 131739; WR 140089; WR 149105; WR 176399; WR 177973; WR 211679; WR 211925;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; DRUG METABOLISM; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MONKEY; MOUSE; NONHUMAN; PHARMACOPHORE; PHOTOTOXICITY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPECIES DIFFERENCE;

3T3 CELLS; ANIMALS; ANTIMALARIALS; AOTIDAE; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; FEMALE; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MALE; MEFLOQUINE; MICE; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; NEURONS; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845247980     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00631-06     Document Type: Article

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